9C7A
Crystal structure of R149W neurodevelopmental disease-associated U2AF2 variant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Splicing factor U2AF 65 kDa subunit | polymer | 204 | 22266.3 | 1 | UniProt (P26368) Pfam (PF00076) | Homo sapiens (human) | U2 auxiliary factor 65 kDa subunit,hU2AF(65),hU2AF65,U2 snRNP auxiliary factor large subunit |
| 2 | B (B) | DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU))-R(P*CP*C)-3') | polymer | 8 | 2449.3 | 1 | synthetic construct | ||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D, E (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 233 | Chemie (HOH) |
Sequence modifications
A: 141 - 341 (UniProt: P26368)
| PDB | External Database | Details |
|---|---|---|
| Gly 138 | - | expression tag |
| Pro 139 | - | expression tag |
| Leu 140 | - | expression tag |
| Trp 149 | Arg 149 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24715.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 138.1 | |
| All* | Total formula weight | 24853.7 |
