5JKF
| Crystal structure of esterase E22 | Descriptor: | Esterase E22 | Authors: | Zhang, Y, Wang, P, Yao, Q. | Deposit date: | 2016-04-26 | Release date: | 2017-04-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.393 Å) | Cite: | Structural basis for substrate recognition and catalysis of a novel esterase E22 with a homoserine transacetylase-like fold To Be Published
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5NCK
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4DEM
| Crystal structure of human FPPS in complex with YS_04_70 | Descriptor: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid) | Authors: | Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. | Deposit date: | 2012-01-20 | Release date: | 2012-03-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells. J.Med.Chem., 55, 2012
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5JPH
| Structure of a GNAT acetyltransferase SACOL1063 from Staphylococcus aureus in complex with CoA | Descriptor: | Acetyltransferase SACOL1063, CHLORIDE ION, COENZYME A | Authors: | Majorek, K.A, Osinski, T, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2016-05-03 | Release date: | 2016-06-29 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Insight into the 3D structure and substrate specificity of previously uncharacterized GNAT superfamily acetyltransferases from pathogenic bacteria. Biochim.Biophys.Acta, 1865, 2016
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3JU5
| Crystal Structure of Dimeric Arginine Kinase at 1.75-A Resolution | Descriptor: | Arginine kinase, MAGNESIUM ION | Authors: | Wu, X, Ye, S, Guo, S, Yan, W, Bartlam, M, Rao, Z. | Deposit date: | 2009-09-14 | Release date: | 2009-09-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity Faseb J., 24, 2010
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5JTF
| Crystal structure of ArsN N-acetyltransferase from Pseudomonas putida KT2440 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Putative Phosphinothricin N-acetyltransferase | Authors: | Venkadesh, S, Dheeman, D.S, Kandavelu, P, Rosen, B.P. | Deposit date: | 2016-05-09 | Release date: | 2017-05-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.156 Å) | Cite: | Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibiotic. Commun Biol, 2, 2019
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5H38
| Structural analysis of KSHV thymidylate synthase | Descriptor: | ORF70, PHOSPHATE ION | Authors: | Choi, Y.M, Yeo, H.K, Park, Y.W, Lee, J.Y. | Deposit date: | 2016-10-21 | Release date: | 2017-01-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed. PLoS ONE, 11, 2016
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4E8O
| Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-Ih from Acinetobacter baumannii | Descriptor: | Aac(6')-Ih protein, CHLORIDE ION | Authors: | Stogios, P.J, Minasov, G, Dong, A, Evdokimova, E, Yim, V, Courvalin, P, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2012-03-20 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.138 Å) | Cite: | Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes. ACS Infect Dis., 3, 2017
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5UCO
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5NEZ
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5UHT
| Structure of the Thermotoga maritima HK853-BeF3-RR468 complex at pH 5.0 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Liu, Y, Rose, J, Jiang, L, Zhou, P. | Deposit date: | 2017-01-12 | Release date: | 2017-12-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases. Nat Commun, 8, 2017
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5GCN
| CATALYTIC DOMAIN OF TETRAHYMENA GCN5 HISTONE ACETYLTRANSFERASE IN COMPLEX WITH COENZYME A | Descriptor: | COENZYME A, HISTONE ACETYLTRANSFERASE GCN5 | Authors: | Lin, Y, Fletcher, C.M, Zhou, J, Allis, C.D, Wagner, G. | Deposit date: | 1999-03-24 | Release date: | 1999-07-19 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A Nature, 400, 1999
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6PCA
| Crystal structure of beta-ketoadipyl-CoA thiolase | Descriptor: | ACETATE ION, Beta-ketoadipyl-CoA thiolase, CHLORIDE ION, ... | Authors: | Sukritee, B, Panjikar, S. | Deposit date: | 2019-06-17 | Release date: | 2020-05-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase. J Struct Biol X, 4, 2020
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6BJ9
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3K9U
| Crystal structure of paia acetyltransferase (ta0374) from thermoplasma acidophilum | Descriptor: | ACETYL COENZYME *A, BROMIDE ION, CHLORIDE ION, ... | Authors: | Filippova, E.V, Minasov, G, Shuvalova, L, Kiryukhina, O, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-10-16 | Release date: | 2009-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production. Proteins, 79, 2011
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5GRR
| Crystal structure of MCR-1 | Descriptor: | GLYCEROL, Probable phosphatidylethanolamine transferase Mcr-1, ZINC ION | Authors: | Ma, G, Zhu, Y, Yu, Z, Zhang, H. | Deposit date: | 2016-08-12 | Release date: | 2017-01-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | High resolution crystal structure of the catalytic domain of MCR-1 Sci Rep, 6, 2016
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6BND
| Crystal structure of the intrinsic colistin resistance enzyme ICR(Mc) from Moraxella catarrhalis, catalytic domain, Thr315Ala mutant mono-zinc and phosphoethanolamine complex | Descriptor: | PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER, POLYETHYLENE GLYCOL (N=34), Phosphoethanolamine transferase, ... | Authors: | Stogios, P.J, Evdokimova, E, Wawrzak, Z, Savchenko, A, Anderson, W.F, Satchell, K.J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2017-11-16 | Release date: | 2018-01-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis. ACS Chem. Biol., 13, 2018
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5TT4
| Determining the Molecular Basis For Starter Unit Selection During Daunorubicin Biosynthesis | Descriptor: | Daunorubicin-doxorubicin polyketide synthase | Authors: | Jackson, D.R, Valentic, T.R, Patel, A, Tsai, S.C, Mohammed, L, Vasilakis, K, Wattana-amorn, P, Long, P.F, Crump, M.P, Crosby, J. | Deposit date: | 2016-11-01 | Release date: | 2016-11-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Determining the Molecular Basis For Starter Unit Selection During Daunorubicin Biosynthesis To Be Published
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5GTI
| Native XFEL structure of photosystem II (two flash dataset) | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | Authors: | Suga, M, Shen, J.R. | Deposit date: | 2016-08-20 | Release date: | 2017-03-15 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL. Nature, 543, 2017
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6BJJ
| Human ABO(H) blood group glycosyltransferase GTB D302A mutant | Descriptor: | ABO blood group (Transferase A, alpha 1-3-N-acetylgalactosaminyltransferase transferase B, alpha 1-3-galactosyltransferase) | Authors: | Gagnon, S.M.L, Legg, M.S.G, Evans, S.V. | Deposit date: | 2017-11-06 | Release date: | 2018-09-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases. Glycobiology, 28, 2018
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5JV0
| Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-038 | Descriptor: | Farnesyl pyrophosphate synthase, SULFATE ION, [(1R)-2-(3-fluorophenyl)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}ethyl]phosphonic acid | Authors: | Park, J, Leung, C.Y, Tsantrizos, Y.S, Berghuis, A.M. | Deposit date: | 2016-05-10 | Release date: | 2017-03-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60, 2017
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5JVJ
| C4-type pyruvate phosphate dikinase: different conformational states of the nucleotide binding domain in the dimer | Descriptor: | MAGNESIUM ION, PHOSPHOENOLPYRUVATE, Pyruvate, ... | Authors: | Minges, A, Hoeppner, A, Groth, G. | Deposit date: | 2016-05-11 | Release date: | 2017-04-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.898 Å) | Cite: | Structural intermediates and directionality of the swiveling motion of Pyruvate Phosphate Dikinase. Sci Rep, 7, 2017
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6P86
| E.coli LpxD in complex with compound 4.1 | Descriptor: | 3-hydroxy-7,7-dimethyl-2-phenyl-4-(thiophen-2-yl)-2,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one, MAGNESIUM ION, N-[(4-ethylphenyl)methyl]-2-[(6aR)-6-oxo-3-(pyrrolidine-1-carbonyl)-6,6a,7,8,9,10-hexahydro-5H-pyrido[1,2-a]quinoxalin-5-yl]acetamide, ... | Authors: | Ma, X, Shia, S. | Deposit date: | 2019-06-06 | Release date: | 2019-08-28 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and Biological Basis of Small Molecule Inhibition ofEscherichia coliLpxD Acyltransferase Essential for Lipopolysaccharide Biosynthesis. Acs Infect Dis., 6, 2020
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5JVN
| C3-type pyruvate phosphate dikinase: intermediate state of the central domain in the swiveling mechanism | Descriptor: | 2'-Bromo-2'-deoxyadenosine 5'-[beta,gamma-imide]triphosphoric acid, MAGNESIUM ION, PHOSPHOENOLPYRUVATE, ... | Authors: | Minges, A, Hoeppner, A, Groth, G. | Deposit date: | 2016-05-11 | Release date: | 2017-04-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural intermediates and directionality of the swiveling motion of Pyruvate Phosphate Dikinase. Sci Rep, 7, 2017
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6BJA
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