4E8O

Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-Ih from Acinetobacter baumannii

Summary for 4E8O

• Entry DOI: 10.2210/pdb4e8o/pdb
• Descriptor: Aac(6')-Ih protein, CHLORIDE ION (3 entities in total)
• Functional Keywords: antibiotic resistance, center for structural genomics of infectious diseases (csgid), niaid, national institute of allergy and infectious diseases, gnat superfamily, gcn5-related n-acetyltransferase superfamily, n-acetyltransferase fold, aminoglycoside antibiotic 6'-n-acetyltransferase, aminoglycoside antibiotics, acetyl coenzyme a, coenzyme a, intracellular, transferase
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 2
• Total formula weight: 38561.38

Authors

Stogios, P.J.,Minasov, G.,Dong, A.,Evdokimova, E.,Yim, V.,Courvalin, P.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-03-20, release date: 2012-04-04, Last modification date: 2023-09-13)

• Primary citation: Stogios, P.J.,Kuhn, M.L.,Evdokimova, E.,Law, M.,Courvalin, P.,Savchenko, A.; Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes.; ACS Infect Dis., 3:132-143, 2017; PubMed: 27785912; DOI: 10.1021/acsinfecdis.6b00058

Experimental method

X-RAY DIFFRACTION (2.138 Å)