4DEM
Crystal structure of human FPPS in complex with YS_04_70
Summary for 4DEM
Entry DOI | 10.2210/pdb4dem/pdb |
Descriptor | Farnesyl pyrophosphate synthase, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid), MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | mevalonate pathway, isoprene biosynthesis, cholesterol biosynthesis, bisphosphonate, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 43620.17 |
Authors | Park, J.,Lin, Y.-S.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2012-01-20, release date: 2012-03-21, Last modification date: 2023-09-13) |
Primary citation | Lin, Y.S.,Park, J.,De Schutter, J.W.,Huang, X.F.,Berghuis, A.M.,Sebag, M.,Tsantrizos, Y.S. Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells. J.Med.Chem., 55:3201-3215, 2012 Cited by PubMed: 22390415DOI: 10.1021/jm201657x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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