4DEM

Crystal structure of human FPPS in complex with YS_04_70

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (F)	Farnesyl pyrophosphate synthase	polymer	375	43145.0	1	UniProt (P14324) Pfam (PF00348)	Homo sapiens (human)	FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase
2	B (F)	[({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid)	non-polymer		402.3	1	Chemie (YS4)
3	C, D, E (F)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
4	F (F)	water	water		18.0	221	Chemie (HOH)

Sequence modifications

F: 15 - 367 (UniProt: P14324)

PDB	External Database	Details
Met -7	-	expression tag
Gly -6	-	expression tag
Ser -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
Ser 3	-	expression tag
Ser 4	-	expression tag
Gly 5	-	expression tag
Arg 6	-	expression tag
Glu 7	-	expression tag
Asn 8	-	expression tag
Leu 9	-	expression tag
Tyr 10	-	expression tag
Phe 11	-	expression tag
Gln 12	-	expression tag
Gly 13	-	expression tag
His 14	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43145.0
Non-Polymers*	Number of molecules	4
	Total formula weight	475.2
All*	Total formula weight	43620.2

*Water molecules are not included.