4KT8
| The complex structure of Rv3378c-Y51FY90F with substrate, TPP | Descriptor: | (2E)-3-methyl-5-[(1R,2S,8aS)-1,2,5,5-tetramethyl-1,2,3,5,6,7,8,8a-octahydronaphthalen-1-yl]pent-2-en-1-yl trihydrogen diphosphate, Diterpene synthase, PHOSPHATE ION | Authors: | Chan, H.C, Feng, X, Ko, T.P, Huang, C.H, Hu, Y, Zheng, Y, Bogue, S, Nakano, C, Hoshino, T, Zhang, L, Lv, P, Liu, W, Crick, D.C, Liang, P.H, Wang, A.H, Oldfield, E, Guo, R.T. | Deposit date: | 2013-05-20 | Release date: | 2014-02-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. J.Am.Chem.Soc., 136, 2014
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6KHR
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5HM3
| 2.25 Angstrom Resolution Crystal Structure of Long-chain-fatty-acid-AMP Ligase FadD32 from Mycobacterium tuberculosis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine | Descriptor: | 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Minasov, G, Warwrzak, Z, Kuhn, M.L, Shuvalova, L, Flores, K.J, Wilson, D.J, Grimes, K.D, Aldrich, C.C, Anderson, W.A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2016-01-15 | Release date: | 2016-08-03 | Last modified: | 2016-09-07 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis. Acs Infect Dis., 2, 2016
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5ICJ
| Crystal structure of the Mycobacterium tuberculosis transcriptional repressor EthR2 in complex with BDM41420 | Descriptor: | 4,4,4-trifluoro-1-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)butan-1-one, Probable transcriptional regulatory protein | Authors: | Wohlkonig, A, Remaut, H, Tanina, A, Meyer, F, Willand, N, Baulard, A.R, Wintjens, R. | Deposit date: | 2016-02-23 | Release date: | 2017-04-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. Science, 355, 2017
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1ISX
| Crystal structure of xylanase from Streptomyces olivaceoviridis E-86 complexed with xylotriose | Descriptor: | beta-D-xylopyranose, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, ... | Authors: | Fujimoto, Z, Kuno, A, Kaneko, S, Kobayashi, H, Kusakabe, I, Mizuno, H. | Deposit date: | 2001-12-27 | Release date: | 2002-02-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of the sugar complexes of Streptomyces olivaceoviridis E-86 xylanase: sugar binding structure of the family 13 carbohydrate binding module. J.Mol.Biol., 316, 2002
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8RWY
| DtpB hexamer from Streptomyces lividans | Descriptor: | Dyp-type peroxidase family, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Worrall, J.A.R, Chaplin, A.K, Allport, T. | Deposit date: | 2024-02-05 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | The oligomeric states of dye-decolorizing peroxidases from Streptomyces lividans and their implications for mechanism of substrate oxidation. Protein Sci., 33, 2024
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6DNP
| Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-F-3-Methyl-6-F-phenyldiketoacid | Descriptor: | (2Z)-4-(2,6-difluoro-3-methylphenyl)-2-hydroxy-4-oxobut-2-enoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, ... | Authors: | Krieger, I.V, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC), Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2018-06-07 | Release date: | 2018-09-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.711 Å) | Cite: | Anion-pi Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids. J Chem Inf Model, 58, 2018
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1ISY
| Crystal structure of xylanase from Streptomyces olivaceoviridis E-86 complexed with glucose | Descriptor: | beta-D-glucopyranose, endo-1,4-beta-D-xylanase | Authors: | Fujimoto, Z, Kuno, A, Kaneko, S, Kobayashi, H, Kusakabe, I, Mizuno, H. | Deposit date: | 2001-12-27 | Release date: | 2002-02-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of the sugar complexes of Streptomyces olivaceoviridis E-86 xylanase: sugar binding structure of the family 13 carbohydrate binding module. J.Mol.Biol., 316, 2002
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3DGT
| The 1.5 A crystal structure of endo-1,3-beta-glucanase from Streptomyces sioyaensis | Descriptor: | Endo-1,3-beta-glucanase, MAGNESIUM ION | Authors: | Li, T.H. | Deposit date: | 2008-06-16 | Release date: | 2008-09-02 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The 1.5 A structure of endo-1,3-beta-glucanase from Streptomyces sioyaensis: evolution of the active-site structure for 1,3-beta-glucan-binding specificity and hydrolysis Acta Crystallogr.,Sect.D, 64, 2008
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6ADQ
| Respiratory Complex CIII2CIV2SOD2 from Mycobacterium smegmatis | Descriptor: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ... | Authors: | Gong, H.R, Xu, A, Gao, R.G, Ji, W.X, Wang, S.H, Wang, Q, Li, J, Rao, Z.H. | Deposit date: | 2018-08-01 | Release date: | 2018-11-14 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science, 362, 2018
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8PYS
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6C04
| Mtb RNAP Holo/RbpA/double fork DNA -closed clamp | Descriptor: | DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M. | Deposit date: | 2017-12-27 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
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6DLY
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6TEJ
| Structure of apo IrtAB devoid SID in complex with sybody Syb_NL5 | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, Drug ABC transporter ATP-binding protein, NICKEL (II) ION, ... | Authors: | Gonda, I, Arnold, F.M, Hutter, C.A.J, Weber, M.S, Seeger, M.A, Hurlimann, L.M. | Deposit date: | 2019-11-12 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The ABC exporter IrtAB imports and reduces mycobacterial siderophores. Nature, 580, 2020
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7KUF
| Transcription activation subcomplex with WhiB7 bound to SigmaAr4-RNAP Beta flap tip chimera and DNA | Descriptor: | DNA (5'-D(*CP*AP*GP*AP*AP*AP*AP*TP*CP*GP*GP*TP*TP*GP*TP*GP*GP*T)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*AP*AP*CP*CP*GP*AP*TP*TP*TP*TP*CP*T)-3'), IRON/SULFUR CLUSTER, ... | Authors: | Wan, T, Horova, M, Beltran, D.G, Li, S.R, Zhang, L.M. | Deposit date: | 2020-11-24 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural insights into the functional divergence of WhiB-like proteins in Mycobacterium tuberculosis. Mol.Cell, 81, 2021
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8RMW
| Alpha-Methylacyl-CoA racemase from Mycobacterium tuberculosis. | Descriptor: | 1,2-ETHANEDIOL, Alpha-methylacyl-CoA racemase, DI(HYDROXYETHYL)ETHER | Authors: | Mojanaga, O.O, Acharya, K.R, Lloyd, M.D. | Deposit date: | 2024-01-09 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | alpha-Methylacyl-CoA Racemase from Mycobacterium tuberculosis -Detailed Kinetic and Structural Characterization of the Active Site. Biomolecules, 14, 2024
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5VIR
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2BNG
| Structure of an M.tuberculosis LEH-like epoxide hydrolase | Descriptor: | CALCIUM ION, MB2760 | Authors: | Johansson, P, Arand, M, Unge, T, Bergfors, T, Jones, T.A, Mowbray, S.L. | Deposit date: | 2005-03-24 | Release date: | 2005-08-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of an Atypical Epoxide Hydrolase from Mycobacterium Tuberculosis Gives Insights Into its Function. J.Mol.Biol., 351, 2005
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6AJI
| Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with Rimonabant | Descriptor: | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide, Drug exporters of the RND superfamily-like protein,Endolysin, ... | Authors: | Zhang, B, Li, J, Yang, X.L, Wu, L.J, Yang, H.T, Rao, Z.H. | Deposit date: | 2018-08-27 | Release date: | 2018-12-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell, 176, 2019
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5XKQ
| Crystal structure of Msmeg3575 in complex with ammeline | Descriptor: | 4,6-diamino-1,3,5-triazin-2-ol, ACETATE ION, CMP/dCMP deaminase, ... | Authors: | Gaded, V.M, Anand, R. | Deposit date: | 2017-05-09 | Release date: | 2017-08-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Selective Deamination of Mutagens by a Mycobacterial Enzyme J. Am. Chem. Soc., 139, 2017
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6D47
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5XKP
| Crystal structure of Msmeg3575 in complex with 5-azacytosine | Descriptor: | 6-amino-1,3,5-triazin-2(1H)-one, ACETATE ION, CMP/dCMP deaminase, ... | Authors: | Gaded, V.M, Anand, R. | Deposit date: | 2017-05-08 | Release date: | 2017-08-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Selective Deamination of Mutagens by a Mycobacterial Enzyme J. Am. Chem. Soc., 139, 2017
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3D8X
| Crystal Structure of Saccharomyces cerevisiae NDPPH Dependent Thioredoxin Reductase 1 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Thioredoxin reductase 1 | Authors: | Zhang, Z.Y, Bao, R, Yu, J, Chen, Y.X, Zhou, C.-Z. | Deposit date: | 2008-05-26 | Release date: | 2008-12-09 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin Biochim.Biophys.Acta, 1794, 2009
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6AJJ
| Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with ICA38 | Descriptor: | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 4,6-difluoro-N-(spiro[5.5]undecan-3-yl)-1H-indole-2-carboxamide, Drug exporters of the RND superfamily-like protein,Endolysin, ... | Authors: | Zhang, B, Li, J, Yang, X.L, Wu, L.J, Yang, H.T, Rao, Z.H. | Deposit date: | 2018-08-27 | Release date: | 2018-12-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.794 Å) | Cite: | Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell, 176, 2019
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6Q58
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