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5HM3

2.25 Angstrom Resolution Crystal Structure of Long-chain-fatty-acid-AMP Ligase FadD32 from Mycobacterium tuberculosis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine

Summary for 5HM3
Entry DOI10.2210/pdb5hm3/pdb
DescriptorLong-chain-fatty-acid--AMP ligase FadD32, 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine, CHLORIDE ION, ... (7 entities in total)
Functional Keywordslong-chain-fatty-acid--amp ligase, fadd32, structural genomics, center for structural genomics of infectious diseases, csgid, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains1
Total formula weight73140.36
Authors
Primary citationKuhn, M.L.,Alexander, E.,Minasov, G.,Page, H.J.,Warwrzak, Z.,Shuvalova, L.,Flores, K.J.,Wilson, D.J.,Shi, C.,Aldrich, C.C.,Anderson, W.F.
Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis.
Acs Infect Dis., 2:579-591, 2016
Cited by
PubMed: 27547819
DOI: 10.1021/acsinfecdis.6b00082
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

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