5ICJ

Crystal structure of the Mycobacterium tuberculosis transcriptional repressor EthR2 in complex with BDM41420

Summary for 5ICJ

• Entry DOI: 10.2210/pdb5icj/pdb
• Descriptor: Probable transcriptional regulatory protein, 4,4,4-trifluoro-1-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)butan-1-one (3 entities in total)
• Functional Keywords: helix-turn-helix dna binding protein, tetr family, transcription, regulatory repressor, inhibitor, transcription repressor-inhibitor complex
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 48925.82

Authors

Wohlkonig, A.,Remaut, H.,Tanina, A.,Meyer, F.,Willand, N.,Baulard, A.R.,Wintjens, R. (deposition date: 2016-02-23, release date: 2017-04-26, Last modification date: 2024-01-10)

• Primary citation: Blondiaux, N.,Moune, M.,Desroses, M.,Frita, R.,Flipo, M.,Mathys, V.,Soetaert, K.,Kiass, M.,Delorme, V.,Djaout, K.,Trebosc, V.,Kemmer, C.,Wintjens, R.,Wohlkonig, A.,Antoine, R.,Huot, L.,Hot, D.,Coscolla, M.,Feldmann, J.,Gagneux, S.,Locht, C.,Brodin, P.,Gitzinger, M.,Deprez, B.,Willand, N.,Baulard, A.R.; Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.; Science, 355:1206-1211, 2017; PubMed: 28302858; DOI: 10.1126/science.aag1006

Experimental method

X-RAY DIFFRACTION (2.4 Å)