5ICJ
Crystal structure of the Mycobacterium tuberculosis transcriptional repressor EthR2 in complex with BDM41420
Summary for 5ICJ
Entry DOI | 10.2210/pdb5icj/pdb |
Descriptor | Probable transcriptional regulatory protein, 4,4,4-trifluoro-1-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)butan-1-one (3 entities in total) |
Functional Keywords | helix-turn-helix dna binding protein, tetr family, transcription, regulatory repressor, inhibitor, transcription repressor-inhibitor complex |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 48925.82 |
Authors | Wohlkonig, A.,Remaut, H.,Tanina, A.,Meyer, F.,Willand, N.,Baulard, A.R.,Wintjens, R. (deposition date: 2016-02-23, release date: 2017-04-26, Last modification date: 2024-01-10) |
Primary citation | Blondiaux, N.,Moune, M.,Desroses, M.,Frita, R.,Flipo, M.,Mathys, V.,Soetaert, K.,Kiass, M.,Delorme, V.,Djaout, K.,Trebosc, V.,Kemmer, C.,Wintjens, R.,Wohlkonig, A.,Antoine, R.,Huot, L.,Hot, D.,Coscolla, M.,Feldmann, J.,Gagneux, S.,Locht, C.,Brodin, P.,Gitzinger, M.,Deprez, B.,Willand, N.,Baulard, A.R. Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. Science, 355:1206-1211, 2017 Cited by PubMed: 28302858DOI: 10.1126/science.aag1006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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