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4Y7R	Crystal structure of WDR5 in complex with MYC MbIIIb peptide Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MYC MbIIIb peptide, ... Authors: Sun, Q, Phan, J, Olejniczak, E.T, Thomas, L.R, Fesik, S.W, Tansey, W.P. Deposit date: 2015-02-16 Release date: 2015-04-15 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.898 Å) Cite: Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC. Mol.Cell, 58, 2015
4U4Y	Crystal structure of Pactamycin bound to the yeast 80S ribosome Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... Authors: Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. Deposit date: 2014-07-24 Release date: 2014-10-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
1MV3	NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC Descriptor: Myc box dependent interacting protein 1 Authors: Pineda-Lucena, A, Arrowsmith, C.H. Deposit date: 2002-09-24 Release date: 2003-09-30 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants. J.Mol.Biol., 351, 2005
1MUZ	NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC Descriptor: Myc box dependent interacting protein 1 Authors: Pineda-Lucena, A, Arrowsmith, C.H. Deposit date: 2002-09-24 Release date: 2003-09-30 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants. J.Mol.Biol., 351, 2005
2VFT	Alditol Oxidase from Streptomyces coelicolor A3(2): Complex with Sorbitol Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, XYLITOL OXIDASE, ... Authors: Forneris, F, Mattevi, A. Deposit date: 2007-11-05 Release date: 2008-01-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Analysis of the Catalytic Mechanism and Stereoselectivity in Streptomyces Coelicolor Alditol Oxidase. Biochemistry, 47, 2008
2VFR	Alditol Oxidase from Streptomyces coelicolor A3(2): Native Enzyme Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, XYLITOL OXIDASE Authors: Forneris, F, Mattevi, A. Deposit date: 2007-11-05 Release date: 2008-01-08 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Structural Analysis of the Catalytic Mechanism and Stereoselectivity in Streptomyces Coelicolor Alditol Oxidase. Biochemistry, 47, 2008
2VFU	Alditol Oxidase from Streptomyces coelicolor A3(2): Complex with Mannitol Descriptor: D-MANNITOL, FLAVIN-ADENINE DINUCLEOTIDE, XYLITOL OXIDASE Authors: Forneris, F, Mattevi, A. Deposit date: 2007-11-05 Release date: 2008-01-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Analysis of the Catalytic Mechanism and Stereoselectivity in Streptomyces Coelicolor Alditol Oxidase. Biochemistry, 47, 2008
2VFS	Alditol Oxidase from Streptomyces coelicolor A3(2): Complex with Xylitol Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, XYLITOL OXIDASE, ... Authors: Forneris, F, Mattevi, A. Deposit date: 2007-11-05 Release date: 2008-01-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Analysis of the Catalytic Mechanism and Stereoselectivity in Streptomyces Coelicolor Alditol Oxidase. Biochemistry, 47, 2008
2VFV	Alditol Oxidase from Streptomyces coelicolor A3(2): Complex with Sulphite Descriptor: (S)-10-((2S,3S,4R)-5-((S)-((S)-(((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHOXY)(HYDROXY)PHOSPHORYLOXY)(HYDROXY)PHOSPHORYLOXY)-2,3,4-TRIHYDROXYPENTYL)-7,8-DIMETHYL-2,4-DIOXO-2,3,4,4A-TETRAHYDROBENZO[G]PTERIDINE-5(10H)-SULFONIC ACID, CHLORIDE ION, XYLITOL OXIDASE Authors: Forneris, F, Mattevi, A. Deposit date: 2007-11-05 Release date: 2008-01-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Structural Analysis of the Catalytic Mechanism and Stereoselectivity in Streptomyces Coelicolor Alditol Oxidase. Biochemistry, 47, 2008
8WX0	PNPase of M.tuberculosis with its RNA substrate Descriptor: Bifunctional guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase, RNA (24-mer) Authors: Wang, N, Sheng, Y.N. Deposit date: 2023-10-27 Release date: 2024-07-03 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation. Arch.Biochem.Biophys., 754, 2024
8TJG	Structure of Nei2 from Mycobacterium smegmatis in complex with Zn2+ Descriptor: DNA-(apurinic or apyrimidinic site) lyase, ZINC ION Authors: Warren, G, Shuman, S. Deposit date: 2023-07-21 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structure of Nei2 from Mycobacterium smegmatis in complex with Zn2+ To Be Published
8UFD	Multidrug efflux pump MtEfpA bound with inhibitor BRD8000.3 Descriptor: (1S,3S)-N-[6-bromo-5-(pyrimidin-2-yl)pyridin-2-yl]-2,2-dimethyl-3-(2-methylpropyl)cyclopropane-1-carboxamide, Integral membrane efflux protein EFPA, PHOSPHATIDYLETHANOLAMINE Authors: Wang, S, Liao, M. Deposit date: 2023-10-04 Release date: 2024-09-11 Method: ELECTRON MICROSCOPY (3.26 Å) Cite: Structures of the Mycobacterium tuberculosis efflux pump EfpA reveal the mechanisms of transport and inhibition. Nat Commun, 15, 2024
8T41	Crystal structure of aminopeptidase N from Mycobacterium tuberculosis Descriptor: Aminopeptidase N, MAGNESIUM ION, ZINC ION Authors: Park, H.W, Moss, D.L, Landry, S.J. Deposit date: 2023-06-08 Release date: 2024-04-17 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Crystal structure of aminopeptidase N from Mycobacterium tuberculosis To Be Published
8TA0	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM881 Descriptor: 3-[2-(3-{[(6M)-2,4-diamino-6-(3-methoxyphenyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-06-26 Release date: 2024-08-28 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM881 To be published
8TBR	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM758 Descriptor: 3-(2-{3-[(2,4-diamino-6-phenylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-06-29 Release date: 2024-08-28 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM758 To be published
8TA1	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM907 Descriptor: 3-(2-{3-[(2,4-diamino-6-cyclohexylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, ACETATE ION, Dihydrofolate reductase, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-06-26 Release date: 2024-08-28 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM907 To be published
8U12	Crystal Structure of Antitoxin Protein Rv0298 of Type II Toxin-antitoxin Systems from Mycobacterium tuberculosis Descriptor: Antitoxin Rv0298, SULFATE ION Authors: Kim, Y, Tesar, C, Endres, M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) Deposit date: 2023-08-30 Release date: 2023-09-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure of Antitoxin Protein Rv0298 of Type II Toxin-antitoxin Systems from Mycobacterium tuberculosis To Be Published
8TXA	Apo Structure of (N1G37) tRNA Methyltransferase from Mycobacterium marinum Descriptor: tRNA (guanine-N(1)-)-methyltransferase Authors: Balsamo, A, Bruno, C, Edele, C, Fabian, T, Jannotta, R, Lee, R, Schryver, D, Warsaw, J, Warsaw, L, Stojanoff, V, Battaile, K, Perez, A, Bolen, R. Deposit date: 2023-08-23 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (1.591 Å) Cite: Apo Structure of (N1G37) tRNA Methyltransferase from Mycobacterium marinum To Be Published
8U3P	1.79 Angstrom resolution crystal structure of KatG from Mycobacterium tuberculosis with an MYW cofactor after heat incubation for 60 minutes Descriptor: ACETATE ION, Catalase-peroxidase, GLYCEROL, ... Authors: Liu, A, Li, J, Ran, D. Deposit date: 2023-09-08 Release date: 2024-09-11 Method: X-RAY DIFFRACTION (1.79 Å) Cite: 1.79 Angstrom resolution crystal structure of KatG from Mycobacterium tuberculosis with an MYW cofactor after heat incubation for 60 minutes To Be Published
7A10	LppS with covalent adduct derived from 1g Descriptor: 4-methoxycyclohexa-2,5-diene-1-thione, L,D-transpeptidase 2 Authors: Schnell, R, Steiner, E.M. Deposit date: 2020-08-11 Release date: 2021-04-21 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.85 Å) Cite: N-Thio-beta-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis. Cell Chem Biol, 28, 2021
7A1E	LppS with covalent adduct derived from 1c Descriptor: ACETATE ION, L,D-transpeptidase 2, phenylmethanethiol Authors: Schnell, R, Steiner, E.M. Deposit date: 2020-08-12 Release date: 2021-04-21 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.77 Å) Cite: N-Thio-beta-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis. Cell Chem Biol, 28, 2021
7A11	LppS with covalent adduct derived from 1E Descriptor: ACETATE ION, L,D-transpeptidase 2, propane-1-thiol Authors: Schnell, R, Steiner, E.M. Deposit date: 2020-08-11 Release date: 2021-04-21 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.65 Å) Cite: N-Thio-beta-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis. Cell Chem Biol, 28, 2021
7A0Z	LppS with covalent adduct derived from 1b Descriptor: L,D-transpeptidase 2, TRIS(HYDROXYETHYL)AMINOMETHANE, benzenethiol Authors: Schnell, R, Steiner, E.M. Deposit date: 2020-08-11 Release date: 2021-04-21 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.45 Å) Cite: N-Thio-beta-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis. Cell Chem Biol, 28, 2021
7A1C	LdtMT2 with covalent adduct derived from N-Thio-beta-lactam 1a Descriptor: DIMETHYL SULFOXIDE, L,D-transpeptidase 2 Authors: Schnell, R, Steiner, E.M. Deposit date: 2020-08-12 Release date: 2021-04-21 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.77 Å) Cite: N-Thio-beta-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis. Cell Chem Biol, 28, 2021
8U2Q	Crystal Structure of Glycine--tRNA ligase active site chimera from Mycobacterium thermoresistibile/tuberculosis (G5A bound) Descriptor: 1,2-ETHANEDIOL, 5'-O-(glycylsulfamoyl)adenosine, CHLORIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-09-06 Release date: 2023-09-13 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Crystal Structure of Glycine--tRNA ligase active site chimera from Mycobacterium thermoresistibile/tuberculosis (G5A bound) To be published

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