7A10
LppS with covalent adduct derived from 1g
Summary for 7A10
Entry DOI | 10.2210/pdb7a10/pdb |
Related | 7A0Z |
Descriptor | L,D-transpeptidase 2, 4-methoxycyclohexa-2,5-diene-1-thione (3 entities in total) |
Functional Keywords | transpeptidase, cell wall, peptidoglycan, antibiotic, beta-lactam, covalent inhibitor, mycobacterium tuberculosis, ligase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 2 |
Total formula weight | 57301.73 |
Authors | Schnell, R.,Steiner, E.M. (deposition date: 2020-08-11, release date: 2021-04-21, Last modification date: 2024-01-31) |
Primary citation | Martelli, G.,Pessatti, T.B.,Steiner, E.M.,Cirillo, M.,Caso, C.,Bisognin, F.,Landreh, M.,Monte, P.D.,Giacomini, D.,Schnell, R. N-Thio-beta-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis. Cell Chem Biol, 28:1321-, 2021 Cited by PubMed: 33826941DOI: 10.1016/j.chembiol.2021.03.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report