8UFD
Multidrug efflux pump MtEfpA bound with inhibitor BRD8000.3
Summary for 8UFD
Entry DOI | 10.2210/pdb8ufd/pdb |
Related | 8WM5 |
EMDB information | 42204 |
Descriptor | Integral membrane efflux protein EFPA, PHOSPHATIDYLETHANOLAMINE, (1S,3S)-N-[6-bromo-5-(pyrimidin-2-yl)pyridin-2-yl]-2,2-dimethyl-3-(2-methylpropyl)cyclopropane-1-carboxamide (3 entities in total) |
Functional Keywords | multidrug efflux pump, efpa, mycobacterium, brd8000.3, transport protein |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 114982.98 |
Authors | |
Primary citation | Wang, S.,Wang, K.,Song, K.,Lai, Z.W.,Li, P.,Li, D.,Sun, Y.,Mei, Y.,Xu, C.,Liao, M. Structures of the Mycobacterium tuberculosis efflux pump EfpA reveal the mechanisms of transport and inhibition. Nat Commun, 15:7710-7710, 2024 Cited by PubMed: 39231991DOI: 10.1038/s41467-024-51948-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.26 Å) |
Structure validation
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