3JAM
| CryoEM structure of 40S-eIF1A-eIF1 complex from yeast | Descriptor: | 18S rRNA, MAGNESIUM ION, RACK1, ... | Authors: | Llacer, J.L, Hussain, T, Ramakrishnan, V. | Deposit date: | 2015-06-17 | Release date: | 2015-08-12 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex. Mol.Cell, 59, 2015
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3JAP
| Structure of a partial yeast 48S preinitiation complex in closed conformation | Descriptor: | 18S rRNA, MAGNESIUM ION, METHIONINE, ... | Authors: | Llacer, J.L, Hussain, T, Ramakrishnan, V. | Deposit date: | 2015-06-18 | Release date: | 2015-08-12 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex. Mol.Cell, 59, 2015
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5A5U
| Structure of mammalian eIF3 in the context of the 43S preinitiation complex | Descriptor: | EUKARYOTIC INITIATION FACTOR 3, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I | Authors: | des-Georges, A, Dhote, V, Kuhn, L, Hellen, C.U.T, Pestova, T.V, Frank, J, Hashem, Y. | Deposit date: | 2015-06-21 | Release date: | 2015-09-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Structure of Mammalian Eif3 in the Context of the 43S Preinitiation Complex. Nature, 525, 2015
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5C9Z
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5A9Q
| Human nuclear pore complex | Descriptor: | NUCLEAR PORE COMPLEX PROTEIN NUP107, NUCLEAR PORE COMPLEX PROTEIN NUP133, NUCLEAR PORE COMPLEX PROTEIN NUP155, ... | Authors: | von Appen, A, Kosinski, J, Sparks, L, Ori, A, DiGuilio, A, Vollmer, B, Mackmull, M, Banterle, N, Parca, L, Kastritis, P, Buczak, K, Mosalaganti, S, Hagen, W, Andres-Pons, A, Lemke, E.A, Bork, P, Antonin, W, Glavy, J.S, Bui, K.H, Beck, M. | Deposit date: | 2015-07-22 | Release date: | 2015-09-30 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (23 Å) | Cite: | In Situ Structural Analysis of the Human Nuclear Pore Complex Nature, 526, 2015
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5CVL
| WDR48 (UAF-1), residues 2-580 | Descriptor: | GOLD ION, PHOSPHATE ION, WD repeat-containing protein 48 | Authors: | HARRIS, S.F, YIN, J. | Deposit date: | 2015-07-27 | Release date: | 2015-10-07 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46. Structure, 23, 2015
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5CVO
| WDR48:USP46~ubiquitin ternary complex | Descriptor: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, ... | Authors: | Harris, S.F, Yin, J. | Deposit date: | 2015-07-27 | Release date: | 2015-10-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.885 Å) | Cite: | Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46. Structure, 23, 2015
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5CVN
| WDR48 (2-580):USP46~ubiquitin ternary complex | Descriptor: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, ... | Authors: | Harris, S.F, Yin, J. | Deposit date: | 2015-07-27 | Release date: | 2015-10-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46. Structure, 23, 2015
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5CXC
| Structure of Ytm1 bound to the C-terminal domain of Erb1 in P 65 2 2 space group | Descriptor: | CHLORIDE ION, Ribosome biogenesis protein ERB1, Ribosome biogenesis protein YTM1 | Authors: | Wegrecki, M, Bravo, J. | Deposit date: | 2015-07-28 | Release date: | 2015-10-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two beta-propellers during the assembly of large ribosomal subunits in eukaryotes. Nucleic Acids Res., 43, 2015
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5CXB
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5CYK
| Structure of Ytm1 bound to the C-terminal domain of Erb1-R486E | Descriptor: | CHLORIDE ION, Ribosome biogenesis protein ERB1, Ribosome biogenesis protein YTM1 | Authors: | Wegrecki, M, Bravo, J. | Deposit date: | 2015-07-30 | Release date: | 2015-10-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two beta-propellers during the assembly of large ribosomal subunits in eukaryotes. Nucleic Acids Res., 43, 2015
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3JB9
| Cryo-EM structure of the yeast spliceosome at 3.6 angstrom resolution | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Yan, C, Hang, J, Wan, R, Huang, M, Wong, C, Shi, Y. | Deposit date: | 2015-08-09 | Release date: | 2015-09-23 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of a yeast spliceosome at 3.6-angstrom resolution Science, 349, 2015
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5DAT
| Complex of yeast 80S ribosome with hypusine-containing eIF5A | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M. | Deposit date: | 2015-08-20 | Release date: | 2016-08-31 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome To Be Published
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5DC3
| Complex of yeast 80S ribosome with non-modified eIF5A | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M. | Deposit date: | 2015-08-23 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome. J.Mol.Biol., 428, 2016
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5DGF
| Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M. | Deposit date: | 2015-08-27 | Release date: | 2016-12-14 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome To Be Published
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5DGE
| Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M. | Deposit date: | 2015-08-27 | Release date: | 2017-01-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome To Be Published
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5DGV
| Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog | Descriptor: | 25S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | Authors: | Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M. | Deposit date: | 2015-08-28 | Release date: | 2016-12-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome To Be Published
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5AMS
| Crystal structure of Sqt1 | Descriptor: | RIBOSOME ASSEMBLY PROTEIN SQT1 | Authors: | Frenois, F, Legrand, P, Fribourg, S. | Deposit date: | 2015-08-31 | Release date: | 2016-01-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Sqt1P is an Eight-Bladed Wd40 Protein Acta Crystallogr.,Sect.F, 72, 2016
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3JBT
| Atomic structure of the Apaf-1 apoptosome | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apoptotic protease-activating factor 1, Cytochrome c, ... | Authors: | Zhou, M, Li, Y, Hu, Q, Bai, X, Huang, W, Yan, C, Scheres, S.H.W, Shi, Y. | Deposit date: | 2015-10-15 | Release date: | 2015-11-18 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1 Genes Dev., 29, 2015
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5EAP
| Crystal structure of human WDR5 in complex with compound 9e | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | Authors: | DONG, A, DOMBROVSKI, L, SMIL, D, GETLIK, M, BOLSHAN, Y, WALKER, J.R, SENISTERRA, G, PODA, G, AL-AWAR, R, SCHAPIRA, M, VEDADI, M, Bountra, C, Edwards, A.M, Arrowsmith, C.H, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | Deposit date: | 2015-10-16 | Release date: | 2015-11-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J. Med. Chem., 59, 2016
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5EAR
| Crystal structure of human WDR5 in complex with compound 9d | Descriptor: | 1,2-ETHANEDIOL, N-[5-(2,3-dihydro-1-benzofuran-7-yl)-2-(4-methylpiperazin-1-yl)phenyl]-3-methylbenzamide, SULFATE ION, ... | Authors: | DONG, A, DOMBROVSKI, L, SMIL, D, GETLIK, M, BOLSHAN, Y, WALKER, J.R, SENISTERRA, G, PODA, G, AL-AWAR, R, SCHAPIRA, M, VEDADI, M, Bountra, C, Edwards, A.M, Arrowsmith, C.H, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | Deposit date: | 2015-10-16 | Release date: | 2015-11-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J. Med. Chem., 59, 2016
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5EAL
| Crystal structure of human WDR5 in complex with compound 9h | Descriptor: | 1,2-ETHANEDIOL, 3-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-quinolin-3-yl-phenyl]benzamide, CHLORIDE ION, ... | Authors: | DONG, A, DOMBROVSKI, L, SMIL, D, GETLIK, M, BOLSHAN, Y, WALKER, J.R, SENISTERRA, G, PODA, G, AL-AWAR, R, SCHAPIRA, M, VEDADI, M, Bountra, C, Edwards, A.M, Arrowsmith, C.H, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | Deposit date: | 2015-10-16 | Release date: | 2015-11-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of human WDR5 in complex with compound 9h to be published
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5EAM
| Crystal structure of human WDR5 in complex with compound 9o | Descriptor: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, ... | Authors: | DONG, A, DOMBROVSKI, L, SMIL, D, GETLIK, M, BOLSHAN, Y, WALKER, J.R, SENISTERRA, G, PODA, G, AL-AWAR, R, SCHAPIRA, M, VEDADI, M, Bountra, C, Edwards, A.M, Arrowsmith, C.H, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | Deposit date: | 2015-10-16 | Release date: | 2015-11-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J. Med. Chem., 59, 2016
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5FLC
| Architecture of human mTOR Complex 1 - 5.9 Angstrom reconstruction | Descriptor: | FKBP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, REGULATORY-ASSOCIATED PROTEIN OF MTOR, ... | Authors: | Aylett, C.H.S, Sauer, E, Imseng, S, Boehringer, D, Hall, M.N, Ban, N, Maier, T. | Deposit date: | 2015-10-23 | Release date: | 2015-12-30 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Architecture of Human Mtor Complex 1 Science, 351, 2016
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5FLX
| Mammalian 40S HCV-IRES complex | Descriptor: | 18S RRNA, 40S RIBOSOMAL PROTEIN S10, 40S RIBOSOMAL PROTEIN S11, ... | Authors: | Yamamoto, H, Collier, M, Loerke, J, Ismer, J, Schmidt, A, Hilal, T, Sprink, T, Yamamoto, K, Mielke, T, Burger, J, Shaikh, T.R, Dabrowski, M, Hildebrand, P.W, Scheerer, P, Spahn, C.M.T. | Deposit date: | 2015-10-28 | Release date: | 2015-12-23 | Last modified: | 2017-08-30 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular Architecture of the Ribosome-Bound Hepatitis C Virus Internal Ribosomal Entry Site RNA. Embo J., 34, 2015
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