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8RC4
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BU of 8rc4 by Molmil
Structure of Integrator-PP2A complex
Descriptor: DSS1, Integrator complex subunit 1, Integrator complex subunit 10, ...
Authors:Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P.
Deposit date:2023-12-06
Release date:2024-02-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
3AV0
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BU of 3av0 by Molmil
Crystal structure of Mre11-Rad50 bound to ATP S
Descriptor: DNA double-strand break repair protein mre11, DNA double-strand break repair rad50 ATPase, GLYCEROL, ...
Authors:Lim, H.S, Kim, J.S, Cho, Y.
Deposit date:2011-02-18
Release date:2011-05-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of the Mre11-Rad50-ATP S Complex: Understanding the Interplay between Mre11 and Rad50
To be Published
1MF8
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BU of 1mf8 by Molmil
Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin
Descriptor: CALCINEURIN B SUBUNIT ISOFORM 1, CALCIUM ION, CALMODULIN-DEPENDENT CALCINEURIN A SUBUNIT, ...
Authors:Jin, L, Harrison, S.C.
Deposit date:2002-08-09
Release date:2002-10-16
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of Human Calcineurin Complexed with Cyclosporin a and Human Cyclophilin
Proc.Natl.Acad.Sci.USA, 99, 2002
4ORB
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BU of 4orb by Molmil
Crystal structure of mouse calcineurin
Descriptor: CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ...
Authors:Ma, L, Li, S.J, Wang, J, Wu, J.W, Wang, Z.X.
Deposit date:2014-02-11
Release date:2015-05-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.108 Å)
Cite:Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
To be Published
5DNY
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BU of 5dny by Molmil
Structure of the ATPrS-Mre11/Rad50-DNA complex
Descriptor: DNA (27-MER), DNA double-strand break repair Rad50 ATPase,DNA double-strand break repair Rad50 ATPase, DNA double-strand break repair protein Mre11, ...
Authors:Liu, Y.
Deposit date:2015-09-10
Release date:2016-02-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex.
Embo J., 35, 2016
5F3W
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BU of 5f3w by Molmil
Structure of the ATPrS-Mre11/Rad50-DNA complex
Descriptor: 27-MER DNA, DNA double-strand break repair Rad50 ATPase,DNA double-strand break repair Rad50 ATPase, DNA double-strand break repair protein Mre11, ...
Authors:Liu, Y.
Deposit date:2015-12-03
Release date:2016-03-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex
Embo J., 35, 2016
8U5G
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BU of 8u5g by Molmil
Crystal structure of the co-expressed SDS22:PP1:I3 complex
Descriptor: E3 ubiquitin-protein ligase PPP1R11, FE (III) ION, PHOSPHATE ION, ...
Authors:Choy, M.S, Peti, W, Page, R.
Deposit date:2023-09-12
Release date:2023-12-06
Last modified:2024-01-03
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to prime metal exchange.
J.Biol.Chem., 300, 2023
3N5U
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BU of 3n5u by Molmil
Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1
Descriptor: CHLORIDE ION, MANGANESE (II) ION, Retinoblastoma-associated protein, ...
Authors:Hirschi, A.M, Cecchini, M, Steinhardt, R.C, Dick, F.A, Rubin, S.M.
Deposit date:2010-05-25
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein.
Nat.Struct.Mol.Biol., 17, 2010
3AUZ
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BU of 3auz by Molmil
Crystal structure of Mre11 with manganese
Descriptor: DNA double-strand break repair protein mre11, GLYCEROL, MANGANESE (II) ION
Authors:Park, Y.B, Cho, Y.
Deposit date:2011-02-18
Release date:2011-05-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.206 Å)
Cite:Crystal Structure of the Mre11-Rad50-ATP S Complex: Understanding the Interplay between Mre11 and Rad50
To be Published
7K36
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BU of 7k36 by Molmil
Cryo-EM structure of STRIPAK complex
Descriptor: INOSITOL HEXAKISPHOSPHATE, MANGANESE (II) ION, MOB-like protein phocein, ...
Authors:Jeong, B.-C, Bai, X.C.
Deposit date:2020-09-10
Release date:2021-03-10
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of the Hippo signaling integrator human STRIPAK.
Nat.Struct.Mol.Biol., 28, 2021
8U89
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BU of 8u89 by Molmil
The structure of the PP2A-B56Delta holoenzyme mutant - E197K
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Wu, C.G, Xing, Y.
Deposit date:2023-09-16
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.
Proc.Natl.Acad.Sci.USA, 121, 2024
8GAE
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BU of 8gae by Molmil
Hsp90 provides platform for CRaf dephosphorylation by PP5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ...
Authors:Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A.
Deposit date:2023-02-22
Release date:2023-04-26
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
6TZ8
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BU of 6tz8 by Molmil
Crystal structure of Cryptococcus neoformans Calceineurin A, Calcineurin B, and FKBP12 with FK-506
Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CALCIUM ION, Calcineurin subunit B, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-08-10
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
Nat Commun, 10, 2019
2NPP
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BU of 2npp by Molmil
Structure of the Protein Phosphatase 2A Holoenzyme
Descriptor: MANGANESE (II) ION, Protein Phosphatase 2, regulatory subunit A (PR 65), ...
Authors:Xu, Y, Chen, Y, Xing, Y, Chao, Y, Shi, Y.
Deposit date:2006-10-28
Release date:2006-12-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the protein phosphatase 2A holoenzyme
Cell(Cambridge,Mass.), 127, 2006
5ZT0
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BU of 5zt0 by Molmil
Crystal Structure of Protein Phosphate 1 Complexed with PP1 binding domain of GL
Descriptor: MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1 regulatory subunit 3B, ...
Authors:Yu, J, Xiang, S.
Deposit date:2018-05-01
Release date:2019-03-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.3204267 Å)
Cite:Structural basis for protein phosphatase 1 recruitment by glycogen-targeting subunits
FEBS J., 285, 2018
5C1V
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BU of 5c1v by Molmil
CRYSTAL STRUCTURE ANALYSIS OF CATALYTIC SUBUNIT OF HUMAN CALCINEURIN
Descriptor: FE (III) ION, PHOSPHATE ION, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, ...
Authors:Guasch, A, Fita, I, Perez-Luque, R, Aparicio, D, Aranguren-Ibanez, A, Perez-Riba, M.
Deposit date:2015-06-15
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization.
Plos One, 10, 2015
7YZO
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BU of 7yzo by Molmil
Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and dsDNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (31-MER), MAGNESIUM ION, ...
Authors:Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P.
Deposit date:2022-02-21
Release date:2022-08-17
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
7SOY
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BU of 7soy by Molmil
The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex
Descriptor: Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Protein phosphatase methylesterase 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Li, Y, Balakrishnan, V.K, Rowse, M, Novikova, I.V, Xing, Y.
Deposit date:2021-11-01
Release date:2022-08-31
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition.
Elife, 11, 2022
3QG5
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BU of 3qg5 by Molmil
The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair
Descriptor: GLYCEROL, Mre11, rad50
Authors:Lammens, K.
Deposit date:2011-01-24
Release date:2011-04-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair.
Cell(Cambridge,Mass.), 145, 2011
6DCX
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BU of 6dcx by Molmil
iASPP-PP-1c structure and targeting of p53
Descriptor: RelA-associated inhibitor, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Authors:Glover, J.N.M, Zhou, Y, Edwards, R.A.
Deposit date:2018-05-08
Release date:2019-05-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.408 Å)
Cite:Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.
Structure, 27, 2019
6S6V
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BU of 6s6v by Molmil
Resting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ATPgS
Descriptor: MAGNESIUM ION, MANGANESE (II) ION, Nuclease SbcCD subunit C, ...
Authors:Kaeshammer, L, Saathoff, J.H, Gut, F, Bartho, J, Alt, A, Kessler, B, Lammens, K, Hopfner, K.P.
Deposit date:2019-07-03
Release date:2019-09-04
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.
Mol.Cell, 76, 2019
2IAE
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BU of 2iae by Molmil
Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme.
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Cho, U.S, Xu, W.
Deposit date:2006-09-07
Release date:2006-12-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.
Nature, 445, 2007
7CUN
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BU of 7cun by Molmil
The structure of human Integrator-PP2A complex
Descriptor: Integrator complex subunit 1, Integrator complex subunit 11, Integrator complex subunit 2, ...
Authors:Zheng, H, Qi, Y, Liu, W, Li, J, Wang, J, Xu, Y.
Deposit date:2020-08-23
Release date:2020-11-25
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Science, 370, 2020
4TUG
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BU of 4tug by Molmil
Crystal structure of MjMre11-DNA2 complex
Descriptor: DNA (5'-D(P*CP*TP*GP*TP*CP*CP*TP*AP*CP*GP*TP*GP*CP*CP*A)-3'), DNA (5'-D(P*GP*CP*AP*CP*GP*TP*AP*GP*GP*AP*CP*AP*GP*C)-3'), DNA double-strand break repair protein Mre11, ...
Authors:Sung, S, Cho, Y.
Deposit date:2014-06-24
Release date:2014-10-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.
Embo J., 33, 2014
4TUI
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BU of 4tui by Molmil
Crystal structure of MjMre11-DNA1 complex
Descriptor: DNA (5'-D(P*TP*CP*CP*TP*AP*CP*GP*TP*GP*CP*CP*AP*G)-3'), DNA (5'-D(P*TP*GP*GP*CP*AP*CP*GP*TP*AP*GP*GP*AP*C)-3'), DNA double-strand break repair protein Mre11
Authors:Sung, S, Cho, Y.
Deposit date:2014-06-24
Release date:2014-10-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.59 Å)
Cite:DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.
Embo J., 33, 2014

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