1MF8
 
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8RC4
 | | Structure of Integrator-PP2A complex | | Descriptor: | DSS1, Integrator complex subunit 1, Integrator complex subunit 10, ... | | Authors: | Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. | | Deposit date: | 2023-12-06 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
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4G9J
 | | Protein Ser/Thr phosphatase-1 in complex with cell-permeable peptide | | Descriptor: | MANGANESE (II) ION, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, synthetic peptide | | Authors: | Sukackaite, R, Chatterjee, J, Beullens, M, Bollen, M, Koehn, M, Hart, D.J. | | Deposit date: | 2012-07-24 | | Release date: | 2012-09-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells.
Angew.Chem.Int.Ed.Engl., 51, 2012
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4ORB
 | | Crystal structure of mouse calcineurin | | Descriptor: | CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ... | | Authors: | Ma, L, Li, S.J, Wang, J, Wu, J.W, Wang, Z.X. | | Deposit date: | 2014-02-11 | | Release date: | 2015-05-20 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.108 Å) | | Cite: | Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
To be Published
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5DNY
 | | Structure of the ATPrS-Mre11/Rad50-DNA complex | | Descriptor: | DNA (27-MER), DNA double-strand break repair Rad50 ATPase,DNA double-strand break repair Rad50 ATPase, DNA double-strand break repair protein Mre11, ... | | Authors: | Liu, Y. | | Deposit date: | 2015-09-10 | | Release date: | 2016-02-24 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.11 Å) | | Cite: | ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex.
Embo J., 35, 2016
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5F3W
 | | Structure of the ATPrS-Mre11/Rad50-DNA complex | | Descriptor: | 27-MER DNA, DNA double-strand break repair Rad50 ATPase,DNA double-strand break repair Rad50 ATPase, DNA double-strand break repair protein Mre11, ... | | Authors: | Liu, Y. | | Deposit date: | 2015-12-03 | | Release date: | 2016-03-02 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.11 Å) | | Cite: | ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex
Embo J., 35, 2016
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8U5G
 | | Crystal structure of the co-expressed SDS22:PP1:I3 complex | | Descriptor: | E3 ubiquitin-protein ligase PPP1R11, FE (III) ION, PHOSPHATE ION, ... | | Authors: | Choy, M.S, Peti, W, Page, R. | | Deposit date: | 2023-09-12 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-03 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to prime metal exchange.
J.Biol.Chem., 300, 2023
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3N5U
 | | Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1 | | Descriptor: | CHLORIDE ION, MANGANESE (II) ION, Retinoblastoma-associated protein, ... | | Authors: | Hirschi, A.M, Cecchini, M, Steinhardt, R.C, Dick, F.A, Rubin, S.M. | | Deposit date: | 2010-05-25 | | Release date: | 2010-08-11 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein.
Nat.Struct.Mol.Biol., 17, 2010
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3AUZ
 | | Crystal structure of Mre11 with manganese | | Descriptor: | DNA double-strand break repair protein mre11, GLYCEROL, MANGANESE (II) ION | | Authors: | Park, Y.B, Cho, Y. | | Deposit date: | 2011-02-18 | | Release date: | 2011-05-25 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.206 Å) | | Cite: | Crystal Structure of the Mre11-Rad50-ATP S Complex: Understanding the Interplay between Mre11 and Rad50
To be Published
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7K36
 | | Cryo-EM structure of STRIPAK complex | | Descriptor: | INOSITOL HEXAKISPHOSPHATE, MANGANESE (II) ION, MOB-like protein phocein, ... | | Authors: | Jeong, B.-C, Bai, X.C. | | Deposit date: | 2020-09-10 | | Release date: | 2021-03-10 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structure of the Hippo signaling integrator human STRIPAK.
Nat.Struct.Mol.Biol., 28, 2021
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8U89
 | | The structure of the PP2A-B56Delta holoenzyme mutant - E197K | | Descriptor: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | | Authors: | Wu, C.G, Xing, Y. | | Deposit date: | 2023-09-16 | | Release date: | 2024-01-10 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.
Proc.Natl.Acad.Sci.USA, 121, 2024
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6TZ8
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8GAE
 | | Hsp90 provides platform for CRaf dephosphorylation by PP5 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... | | Authors: | Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. | | Deposit date: | 2023-02-22 | | Release date: | 2023-04-26 | | Last modified: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
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2NPP
 | | Structure of the Protein Phosphatase 2A Holoenzyme | | Descriptor: | MANGANESE (II) ION, Protein Phosphatase 2, regulatory subunit A (PR 65), ... | | Authors: | Xu, Y, Chen, Y, Xing, Y, Chao, Y, Shi, Y. | | Deposit date: | 2006-10-28 | | Release date: | 2006-12-12 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structure of the protein phosphatase 2A holoenzyme
Cell(Cambridge,Mass.), 127, 2006
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5ZT0
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5C1V
 | | CRYSTAL STRUCTURE ANALYSIS OF CATALYTIC SUBUNIT OF HUMAN CALCINEURIN | | Descriptor: | FE (III) ION, PHOSPHATE ION, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, ... | | Authors: | Guasch, A, Fita, I, Perez-Luque, R, Aparicio, D, Aranguren-Ibanez, A, Perez-Riba, M. | | Deposit date: | 2015-06-15 | | Release date: | 2016-02-03 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization.
Plos One, 10, 2015
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7SOY
 | | The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex | | Descriptor: | Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Protein phosphatase methylesterase 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | | Authors: | Li, Y, Balakrishnan, V.K, Rowse, M, Novikova, I.V, Xing, Y. | | Deposit date: | 2021-11-01 | | Release date: | 2022-08-31 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition.
Elife, 11, 2022
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7YZO
 | | Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and dsDNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (31-MER), MAGNESIUM ION, ... | | Authors: | Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P. | | Deposit date: | 2022-02-21 | | Release date: | 2022-08-17 | | Last modified: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
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3QG5
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6DCX
 | | iASPP-PP-1c structure and targeting of p53 | | Descriptor: | RelA-associated inhibitor, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | | Authors: | Glover, J.N.M, Zhou, Y, Edwards, R.A. | | Deposit date: | 2018-05-08 | | Release date: | 2019-05-15 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.408 Å) | | Cite: | Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.
Structure, 27, 2019
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7CUN
 | | The structure of human Integrator-PP2A complex | | Descriptor: | Integrator complex subunit 1, Integrator complex subunit 11, Integrator complex subunit 2, ... | | Authors: | Zheng, H, Qi, Y, Liu, W, Li, J, Wang, J, Xu, Y. | | Deposit date: | 2020-08-23 | | Release date: | 2020-11-25 | | Last modified: | 2020-12-09 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Science, 370, 2020
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6S6V
 | | Resting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ATPgS | | Descriptor: | MAGNESIUM ION, MANGANESE (II) ION, Nuclease SbcCD subunit C, ... | | Authors: | Kaeshammer, L, Saathoff, J.H, Gut, F, Bartho, J, Alt, A, Kessler, B, Lammens, K, Hopfner, K.P. | | Deposit date: | 2019-07-03 | | Release date: | 2019-09-04 | | Last modified: | 2019-11-20 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.
Mol.Cell, 76, 2019
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2IAE
 | | Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme. | | Descriptor: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | | Authors: | Cho, U.S, Xu, W. | | Deposit date: | 2006-09-07 | | Release date: | 2006-12-26 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.
Nature, 445, 2007
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4TUG
 | | Crystal structure of MjMre11-DNA2 complex | | Descriptor: | DNA (5'-D(P*CP*TP*GP*TP*CP*CP*TP*AP*CP*GP*TP*GP*CP*CP*A)-3'), DNA (5'-D(P*GP*CP*AP*CP*GP*TP*AP*GP*GP*AP*CP*AP*GP*C)-3'), DNA double-strand break repair protein Mre11, ... | | Authors: | Sung, S, Cho, Y. | | Deposit date: | 2014-06-24 | | Release date: | 2014-10-15 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.55 Å) | | Cite: | DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.
Embo J., 33, 2014
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4TUI
 | | Crystal structure of MjMre11-DNA1 complex | | Descriptor: | DNA (5'-D(P*TP*CP*CP*TP*AP*CP*GP*TP*GP*CP*CP*AP*G)-3'), DNA (5'-D(P*TP*GP*GP*CP*AP*CP*GP*TP*AP*GP*GP*AP*C)-3'), DNA double-strand break repair protein Mre11 | | Authors: | Sung, S, Cho, Y. | | Deposit date: | 2014-06-24 | | Release date: | 2014-10-15 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.59 Å) | | Cite: | DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.
Embo J., 33, 2014
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