6TZ8

Crystal structure of Cryptococcus neoformans Calceineurin A, Calcineurin B, and FKBP12 with FK-506

Summary for 6TZ8

• Entry DOI: 10.2210/pdb6tz8/pdb
• Descriptor: Serine/threonine-protein phosphatase 2B catalytic subunit A1, Calcineurin subunit B, FK506-binding protein 1, ... (9 entities in total)
• Functional Keywords: calcineurin a, cna, cnb, fkbp12, fk-506, structural genomics, seattle structural genomics center for infectious disease, ssgcid, hydrolase-isomerase-calcium binding complex, hydrolase/isomerase/calcium binding
• Biological source: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487); More
• Total number of polymer chains: 6
• Total formula weight: 159032.63

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2019-08-10, release date: 2019-09-18, Last modification date: 2023-10-11)

• Primary citation: Juvvadi, P.R.,Fox 3rd, D.,Bobay, B.G.,Hoy, M.J.,Gobeil, S.M.C.,Venters, R.A.,Chang, Z.,Lin, J.J.,Averette, A.F.,Cole, D.C.,Barrington, B.C.,Wheaton, J.D.,Ciofani, M.,Trzoss, M.,Li, X.,Lee, S.C.,Chen, Y.L.,Mutz, M.,Spicer, L.D.,Schumacher, M.A.,Heitman, J.,Steinbach, W.J.; Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.; Nat Commun, 10:4275-4275, 2019; PubMed: 31537789; DOI: 10.1038/s41467-019-12199-1

Experimental method

X-RAY DIFFRACTION (3.3 Å)