Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0033192 | molecular_function | calmodulin-dependent protein phosphatase activity |
| A | 0097720 | biological_process | calcineurin-mediated signaling |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005955 | cellular_component | calcineurin complex |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016853 | molecular_function | isomerase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0033192 | molecular_function | calmodulin-dependent protein phosphatase activity |
| D | 0097720 | biological_process | calcineurin-mediated signaling |
| E | 0005509 | molecular_function | calcium ion binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005955 | cellular_component | calcineurin complex |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0016853 | molecular_function | isomerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | HIS122 |
| A | ARG152 |
| A | ASN180 |
| A | HIS181 |
| A | ARG284 |
| A | HIS311 |
| A | FE502 |
| A | ZN503 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue FE A 502 |
| Chain | Residue |
| A | HIS122 |
| A | ASP148 |
| A | HIS311 |
| A | SO4501 |
| A | ZN503 |
| A | ASP120 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 503 |
| Chain | Residue |
| A | ASP148 |
| A | ASN180 |
| A | HIS229 |
| A | HIS311 |
| A | SO4501 |
| A | FE502 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 A 504 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 300 |
| Chain | Residue |
| B | ASP34 |
| B | ASP36 |
| B | SER38 |
| B | SER40 |
| B | GLU45 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 301 |
| Chain | Residue |
| B | ASP66 |
| B | ASP68 |
| B | SER70 |
| B | THR72 |
| B | GLU77 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 302 |
| Chain | Residue |
| B | ASP103 |
| B | ASP105 |
| B | ASP107 |
| B | TYR109 |
| B | GLU114 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 303 |
| Chain | Residue |
| B | ASP144 |
| B | ASP146 |
| B | ASP148 |
| B | LYS150 |
| B | GLU155 |
| site_id | AC9 |
| Number of Residues | 18 |
| Details | binding site for residue FK5 C 200 |
| Chain | Residue |
| A | TRP382 |
| A | SER383 |
| A | PHE386 |
| A | GLU389 |
| A | HOH601 |
| B | VAL123 |
| C | TYR27 |
| C | PHE37 |
| C | ASP38 |
| C | ARG43 |
| C | PHE47 |
| C | GLN55 |
| C | VAL56 |
| C | ILE57 |
| C | TYR83 |
| C | PHE88 |
| C | ILE92 |
| C | PHE100 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 D 500 |
| Chain | Residue |
| D | HIS122 |
| D | ASP148 |
| D | ARG152 |
| D | ASN180 |
| D | HIS181 |
| D | ARG284 |
| D | HIS311 |
| D | FE501 |
| D | ZN502 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue FE D 501 |
| Chain | Residue |
| D | ASP120 |
| D | HIS122 |
| D | ASP148 |
| D | HIS311 |
| D | SO4500 |
| D | ZN502 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue ZN D 502 |
| Chain | Residue |
| D | ASP148 |
| D | ASN180 |
| D | HIS229 |
| D | HIS311 |
| D | SO4500 |
| D | FE501 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue CA E 300 |
| Chain | Residue |
| E | ASP34 |
| E | ASP36 |
| E | SER38 |
| E | SER40 |
| E | GLU45 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue CA E 301 |
| Chain | Residue |
| E | ASP66 |
| E | ASP68 |
| E | SER70 |
| E | THR72 |
| E | GLU77 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue CA E 302 |
| Chain | Residue |
| E | ASP103 |
| E | ASP105 |
| E | ASP107 |
| E | TYR109 |
| E | GLU114 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue CA E 303 |
| Chain | Residue |
| E | GLU155 |
| E | ASP144 |
| E | ASP146 |
| E | ASP148 |
| E | LYS150 |
| site_id | AD8 |
| Number of Residues | 17 |
| Details | binding site for residue FK5 F 200 |
| Chain | Residue |
| D | TRP382 |
| D | SER383 |
| D | PHE386 |
| D | GLU389 |
| D | HOH601 |
| E | VAL123 |
| F | TYR27 |
| F | PHE37 |
| F | ASP38 |
| F | ARG43 |
| F | PHE47 |
| F | GLN55 |
| F | VAL56 |
| F | ILE57 |
| F | TYR83 |
| F | PHE88 |
| F | PHE100 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGSGSIDkdEF |
| Chain | Residue | Details |
| B | ASP34-PHE46 | |
| B | ASP66-PHE78 | |
| B | ASP103-LEU115 | |
| B | ASP144-PHE156 | |
| site_id | PS00125 |
| Number of Residues | 6 |
| Details | SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE |
| Chain | Residue | Details |
| A | LEU177-GLU182 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 176 |
| Details | Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]} |
