7QCR
 
 | | MLLT4/Afadin PDZ domain in complex with the C-terminal peptide from protein E of SARS-CoV-2 | | Descriptor: | Afadin, Envelope small membrane protein, SULFATE ION | | Authors: | Zhu, Y, Alvarez, F, Haouz, A, Mechaly, A, Caillet-Saguy, C. | | Deposit date: | 2021-11-25 | | Release date: | 2022-04-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.
Front Microbiol, 13, 2022
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7QCS
 | | PALS1/MPP5 PDZ domain in complex with SARS-CoV-2_E PBM peptide | | Descriptor: | Envelope small membrane protein, Protein PALS1 | | Authors: | Zhu, Y, Alvarez, F, Haouz, A, Mechaly, A, Caillet-Saguy, C. | | Deposit date: | 2021-11-25 | | Release date: | 2022-04-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.804 Å) | | Cite: | Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.
Front Microbiol, 13, 2022
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8FDS
 | | Ankyrin domain of SKD3 isoform 2 | | Descriptor: | Caseinolytic peptidase B protein homolog, FORMIC ACID | | Authors: | Lee, S, Tsai, F.T.F, Chang, C. | | Deposit date: | 2022-12-04 | | Release date: | 2023-04-19 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural basis of impaired disaggregase function in the oxidation-sensitive SKD3 mutant causing 3-methylglutaconic aciduria.
Nat Commun, 14, 2023
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5MSE
 | | GFP nuclear transport receptor mimic 3B8 | | Descriptor: | Green fluorescent protein, IMIDAZOLE, SODIUM ION | | Authors: | Huyton, T, Gorlich, D. | | Deposit date: | 2017-01-04 | | Release date: | 2018-05-02 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Surface Properties Determining Passage Rates of Proteins through Nuclear Pores.
Cell, 174, 2018
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6IG9
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7UPG
 | | Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours | | Descriptor: | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, Isoform Tau-F of Microtubule-associated protein tau | | Authors: | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | | Deposit date: | 2022-04-15 | | Release date: | 2022-09-28 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Nat Commun, 13, 2022
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6Y9P
 | | Crystal structure of Whirlin PDZ3_C-ter in complex with Harmonin a1 C-terminal PDZ binding motif peptide | | Descriptor: | Harmonin a1, Whirlin | | Authors: | Zhu, Y, Delhommel, F, Haouz, A, Caillet-Saguy, C, Vaney, M, Mechaly, A.E, Wolff, N. | | Deposit date: | 2020-03-10 | | Release date: | 2020-10-07 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.169 Å) | | Cite: | Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.
J.Mol.Biol., 432, 2020
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6Y38
 | | Crystal structure of Whirlin PDZ3 in complex with Myosin 15a C-terminal PDZ binding motif peptide | | Descriptor: | Chains: C,D, Whirlin | | Authors: | Zhu, Y, Delhommel, F, Haouz, A, Caillet-Saguy, C, Vaney, M, Mechaly, A.E, Wolff, N. | | Deposit date: | 2020-02-17 | | Release date: | 2020-10-07 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.697 Å) | | Cite: | Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.
J.Mol.Biol., 432, 2020
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1BQ2
 | | E. COLI THYMIDYLATE SYNTHASE MUTANT N177A | | Descriptor: | PHOSPHATE ION, THYMIDYLATE SYNTHASE | | Authors: | Reyes, C.L, Sage, C.R, Rutenber, E.E, Finer-Moore, J.S, Stroud, R.M. | | Deposit date: | 1998-08-20 | | Release date: | 1999-04-27 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer.
J.Mol.Biol., 284, 1998
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6Y9N
 | | Crystal structure of Whirlin PDZ3_C-ter in complex with Myosin 15a C-terminal PDZ binding motif peptide | | Descriptor: | Unconventional myosin-XV, Whirlin | | Authors: | Zhu, Y, Delhommel, F, Haouz, A, Caillet-Saguy, C, Vaney, M, Mechaly, A.E, Wolff, N. | | Deposit date: | 2020-03-10 | | Release date: | 2020-10-07 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.
J.Mol.Biol., 432, 2020
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6Y9O
 | | Crystal structure of Whirlin PDZ3_C-ter in complex with CASK internal PDZ binding motif peptide | | Descriptor: | Peripheral plasma membrane protein CASK, Whirlin | | Authors: | Zhu, Y, Delhommel, F, Haouz, A, Caillet-Saguy, C, Vaney, M, Mechaly, A.E, Wolff, N. | | Deposit date: | 2020-03-10 | | Release date: | 2020-10-07 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.632 Å) | | Cite: | Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.
J.Mol.Biol., 432, 2020
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6Y9Q
 | | Crystal structure of Whirlin PDZ3_C-ter in complex with Taperin internal PDZ binding motif peptide | | Descriptor: | Taperin, Whirlin | | Authors: | Zhu, Y, Delhommel, F, Haouz, A, Caillet-Saguy, C, Vaney, M, Mechaly, A.E, Wolff, N. | | Deposit date: | 2020-03-10 | | Release date: | 2020-10-07 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.315 Å) | | Cite: | Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.
J.Mol.Biol., 432, 2020
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1D2G
 | | CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE FROM RAT LIVER | | Descriptor: | GLYCINE N-METHYLTRANSFERASE | | Authors: | Huang, Y, Komoto, J, Takusagawa, F, Konishi, K, Takata, Y. | | Deposit date: | 1999-10-08 | | Release date: | 1999-10-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
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1D2C
 | | METHYLTRANSFERASE | | Descriptor: | PROTEIN (GLYCINE N-METHYLTRANSFERASE) | | Authors: | Huang, Y, Takusagawa, F. | | Deposit date: | 1999-09-23 | | Release date: | 1999-10-06 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
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1D2H
 | | CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLHOMOCYSTEINE | | Descriptor: | GLYCINE N-METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Huang, Y, Komoto, J, Takusagawa, F, Konishi, K, Takata, Y. | | Deposit date: | 1999-10-11 | | Release date: | 1999-10-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
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1D4F
 | | CRYSTAL STRUCTURE OF RECOMBINANT RAT-LIVER D244E MUTANT S-ADENOSYLHOMOCYSTEINE HYDROLASE | | Descriptor: | ADENOSINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, S-ADENOSYLHOMOCYSTEINE HYDROLASE | | Authors: | Komoto, J, Huang, Y, Takusagawa, F, Gomi, T, Ogawa, H, Takata, Y, Fujioka, M. | | Deposit date: | 2000-06-22 | | Release date: | 2001-01-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Effects of site-directed mutagenesis on structure and function of recombinant rat liver S-adenosylhomocysteine hydrolase. Crystal structure of D244E mutant enzyme.
J.Biol.Chem., 275, 2000
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7UPE
 | | Tau Paired Helical Filament from Alzheimer's Disease not incubated with EGCG | | Descriptor: | Isoform Tau-F of Microtubule-associated protein tau | | Authors: | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | | Deposit date: | 2022-04-15 | | Release date: | 2022-09-28 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Nat Commun, 13, 2022
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7UPF
 | | Tau Paired Helical Filament from Alzheimer's Disease incubated 1 hr. with EGCG | | Descriptor: | Isoform Tau-F of Microtubule-associated protein tau | | Authors: | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | | Deposit date: | 2022-04-15 | | Release date: | 2022-09-28 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Nat Commun, 13, 2022
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1DDU
 | | E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 AND 2',5'-DIDEOXYURIDINE (DDURD) | | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-5'DIDEOXYURIDINE, PHOSPHATE ION, ... | | Authors: | Stout, T.J, Sage, C.R, Stroud, R.M. | | Deposit date: | 1997-06-26 | | Release date: | 1998-07-01 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The additivity of substrate fragments in enzyme-ligand binding.
Structure, 6, 1998
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8K4U
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6N1P
 | | Dihedral oligomeric complex of GyrA N-terminal fragment with DNA, solved by cryoEM in C2 symmetry | | Descriptor: | DNA (44-MER), DNA gyrase subunit A | | Authors: | Soczek, K.M, Grant, T, Rosenthal, P.B, Mondragon, A. | | Deposit date: | 2018-11-10 | | Release date: | 2018-12-05 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (6.35 Å) | | Cite: | CryoEM structures of open dimers of Gyrase A in complex with DNA illuminate mechanism of strand passage.
Elife, 7, 2018
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6N1Q
 | | Dihedral oligomeric complex of GyrA N-terminal fragment, solved by cryoEM in D2 symmetry | | Descriptor: | DNA gyrase subunit A | | Authors: | Soczek, K.M, Grant, T, Rosenthal, P.B, Mondragon, A. | | Deposit date: | 2018-11-10 | | Release date: | 2018-12-05 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (5.16 Å) | | Cite: | CryoEM structures of open dimers of Gyrase A in complex with DNA illuminate mechanism of strand passage.
Elife, 7, 2018
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7VY0
 | | Coxsackievirus B3 full particle at pH7.4 (VP3-234N) | | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | | Authors: | Wang, Q.L, Liu, C.C. | | Deposit date: | 2021-11-13 | | Release date: | 2022-01-19 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Molecular basis of differential receptor usage for naturally occurring CD55-binding and -nonbinding coxsackievirus B3 strains.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VXZ
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7VXH
 | | Coxsackievirus B3 full particle at pH7.4 (VP3-234Q) | | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | | Authors: | Wang, Q.L, Liu, C.C. | | Deposit date: | 2021-11-12 | | Release date: | 2022-01-19 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Molecular basis of differential receptor usage for naturally occurring CD55-binding and -nonbinding coxsackievirus B3 strains.
Proc.Natl.Acad.Sci.USA, 119, 2022
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