3JW3
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![BU of 3jw3 by Molmil](/molmil-images/mine/3jw3) | |
3JWM
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![BU of 3jwm by Molmil](/molmil-images/mine/3jwm) | Crystal structure of Bacillus anthracis dihydrofolate reductase complexed with NADPH and (S)-2,4-diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (UCP114A) | Descriptor: | 5-[(3S)-3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Anderson, A.C, Beierlein, J.M, Karri, N.G. | Deposit date: | 2009-09-18 | Release date: | 2010-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Mutational Studies into Trimethoprim Resistance in Bacillus anthracis Dihydrofolate Reductase To be Published
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3KFY
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![BU of 3kfy by Molmil](/molmil-images/mine/3kfy) | Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR | Descriptor: | 5-[(4-chlorophenyl)sulfanyl]quinazoline-2,4-diamine, CALCIUM ION, Dihydrofolate reductase, ... | Authors: | Collins, E.J, Lee, A.L, Carroll, M.J, Gromova, A.V, Miller, K.R, Singleton, S.F. | Deposit date: | 2009-10-28 | Release date: | 2010-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR To be Published
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1TDR
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![BU of 1tdr by Molmil](/molmil-images/mine/1tdr) | EXPRESSION, CHARACTERIZATION, AND CRYSTALLOGRAPHIC ANALYSIS OF TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE | Descriptor: | CALCIUM ION, CHLORIDE ION, METHOTREXATE, ... | Authors: | Lewinski, K, Lebioda, L. | Deposit date: | 1995-04-13 | Release date: | 1995-07-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Expression, characterization and crystallographic analysis of telluromethionyl dihydrofolate reductase. Acta Crystallogr.,Sect.D, 51, 1995
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1U71
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![BU of 1u71 by Molmil](/molmil-images/mine/1u71) | Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH | Descriptor: | 6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE, Dihydrofolate reductase, SULFATE ION | Authors: | Cody, V, Luft, J.R, Pangborn, W. | Deposit date: | 2004-08-02 | Release date: | 2005-02-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr.,Sect.D, 61, 2005
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1U70
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![BU of 1u70 by Molmil](/molmil-images/mine/1u70) | |
1RX5
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![BU of 1rx5 by Molmil](/molmil-images/mine/1rx5) | |
1RX9
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![BU of 1rx9 by Molmil](/molmil-images/mine/1rx9) | |
1RB3
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![BU of 1rb3 by Molmil](/molmil-images/mine/1rb3) | |
1RA2
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![BU of 1ra2 by Molmil](/molmil-images/mine/1ra2) | |
1RA8
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![BU of 1ra8 by Molmil](/molmil-images/mine/1ra8) | |
1U72
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![BU of 1u72 by Molmil](/molmil-images/mine/1u72) | |
1S3U
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![BU of 1s3u by Molmil](/molmil-images/mine/1s3u) | Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry | Descriptor: | (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine, Dihydrofolate reductase, SULFATE ION | Authors: | Cody, V, Luft, J.R, Pangborn, W, Gangjee, A, Queener, S.F. | Deposit date: | 2004-01-14 | Release date: | 2004-03-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60, 2004
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1RX3
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![BU of 1rx3 by Molmil](/molmil-images/mine/1rx3) | |
1RA1
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![BU of 1ra1 by Molmil](/molmil-images/mine/1ra1) | |
1RA3
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![BU of 1ra3 by Molmil](/molmil-images/mine/1ra3) | |
1RD7
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![BU of 1rd7 by Molmil](/molmil-images/mine/1rd7) | DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE | Descriptor: | BETA-MERCAPTOETHANOL, DIHYDROFOLATE REDUCTASE, FOLIC ACID | Authors: | Sawaya, M.R, Kraut, J. | Deposit date: | 1996-11-01 | Release date: | 1996-12-23 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
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1RX7
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![BU of 1rx7 by Molmil](/molmil-images/mine/1rx7) | STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE | Descriptor: | DIHYDROFOLATE REDUCTASE, FOLIC ACID | Authors: | Sawaya, M.R. | Deposit date: | 1996-10-25 | Release date: | 1997-03-12 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
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1RX1
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![BU of 1rx1 by Molmil](/molmil-images/mine/1rx1) | |
1RX8
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![BU of 1rx8 by Molmil](/molmil-images/mine/1rx8) | |
1RX4
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![BU of 1rx4 by Molmil](/molmil-images/mine/1rx4) | |
1S3V
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![BU of 1s3v by Molmil](/molmil-images/mine/1s3v) | Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry | Descriptor: | (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine, Dihydrofolate reductase, SULFATE ION | Authors: | Cody, V, Luft, J.R, Pangborn, W, Gangjee, A, Queener, S.F. | Deposit date: | 2004-01-14 | Release date: | 2004-03-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60, 2004
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1RC4
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![BU of 1rc4 by Molmil](/molmil-images/mine/1rc4) | |
1S3W
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![BU of 1s3w by Molmil](/molmil-images/mine/1s3w) | Structure Determination of Tetrahydroquinazoline Antifoaltes in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry | Descriptor: | 6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Cody, V, Luft, J.R, Pangborn, W, Gangjee, A, Queener, S.F. | Deposit date: | 2004-01-14 | Release date: | 2004-03-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60, 2004
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1S3Y
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![BU of 1s3y by Molmil](/molmil-images/mine/1s3y) | Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry | Descriptor: | 6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Cody, V, Luft, J.R, Pangborn, W, Gangjee, A, Queener, S.F. | Deposit date: | 2004-01-14 | Release date: | 2004-03-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60, 2004
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