3KFY

Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR

Summary for 3KFY

• Entry DOI: 10.2210/pdb3kfy/pdb
• Related: 1DHF 3K45
• Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(4-chlorophenyl)sulfanyl]quinazoline-2,4-diamine, ... (5 entities in total)
• Functional Keywords: small molecule inhibitor, dynamics, antibiotic resistance, methotrexate resistance, nadp, one-carbon metabolism, oxidoreductase, trimethoprim resistance
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 19188.76

Authors

Collins, E.J.,Lee, A.L.,Carroll, M.J.,Gromova, A.V.,Miller, K.R.,Singleton, S.F. (deposition date: 2009-10-28, release date: 2010-12-08, Last modification date: 2023-09-06)

• Primary citation: Collins, E.J.,Lee, A.L.,Carroll, M.J.,Gromova, A.V.,Miller, K.R.,Singleton, S.F.; Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR; To be Published,

Experimental method

X-RAY DIFFRACTION (2.08 Å)