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7STJ	Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 1) Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-14 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STI	Full-length insulin receptor bound with unsaturated insulin WT (1 insulin bound) asymmetric conformation Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-13 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STK	Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 2) Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-14 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
4BQ6	Crystal structure of the RGMB-NEO1 complex form 1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, NEOGENIN, RGM DOMAIN FAMILY MEMBER B Authors: Bell, C.H, Healey, E, van Erp, S, Bishop, B, Tang, C, Gilbert, R.J.C, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. Deposit date: 2013-05-30 Release date: 2013-06-12 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the Repulsive Guidance Molecule (Rgm)-Neogenin Signaling Hub Science, 341, 2013
6MOH	Dimeric DARPin C_R3 complex with EpoR Descriptor: Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ... Authors: Jude, K.M, Mohan, K, Garcia, K.C. Deposit date: 2018-10-04 Release date: 2019-06-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
6MOI	Dimeric DARPin C_angle_R5 complex with EpoR Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Dimeric DARPing CCR5 (C_angle_R5), ... Authors: Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. Deposit date: 2018-10-04 Release date: 2019-06-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.065 Å) Cite: Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
4BQ7	Crystal structure of the RGMB-Neo1 complex form 2 Descriptor: NEOGENIN, RGM DOMAIN FAMILY MEMBER B Authors: Bell, C.H, Healey, E, van Erp, S, Bishop, B, Tang, C, Gilbert, R.J.C, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. Deposit date: 2013-05-30 Release date: 2013-06-12 Last modified: 2019-04-03 Method: X-RAY DIFFRACTION (6.601 Å) Cite: Structure of the Repulsive Guidance Molecule (Rgm)-Neogenin Signaling Hub Science, 341, 2013
6MOK	Dimeric DARPin A_distance_R7 complex with EpoR Descriptor: Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor Authors: Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. Deposit date: 2018-10-04 Release date: 2019-06-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (5.101 Å) Cite: Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
4BQ8	Crystal structure of the RGMB-NEO1 complex form 3 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, NEOGENIN, RGM DOMAIN FAMILY MEMBER B Authors: Bell, C.H, Healey, E, van Erp, S, Bishop, B, Tang, C, Gilbert, R.J.C, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. Deposit date: 2013-05-30 Release date: 2013-06-12 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of the Repulsive Guidance Molecule (Rgm)-Neogenin Signaling Hub Science, 341, 2013
6MOJ	Dimeric DARPin A_angle_R5 complex with EpoR Descriptor: D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ... Authors: Jude, K.M, Mohan, K, Garcia, K.C. Deposit date: 2018-10-04 Release date: 2019-06-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.431 Å) Cite: Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
7U7N	IL-27 quaternary receptor signaling complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... Authors: Caveney, N.A, Glassman, C.R, Jude, K.M, Tsutsumi, N, Garcia, K.C. Deposit date: 2022-03-07 Release date: 2022-05-25 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Structure of the IL-27 quaternary receptor signaling complex. Elife, 11, 2022
6MOE	Monomeric DARPin E2 complex with EpoR Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ... Authors: Jude, K.M, Mohan, K, Garcia, K.C. Deposit date: 2018-10-04 Release date: 2019-06-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.091 Å) Cite: Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
7U6E	Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IM462, ... Authors: Kirk, N.S, Lawrence, M.C. Deposit date: 2022-03-03 Release date: 2022-10-05 Method: ELECTRON MICROSCOPY (3 Å) Cite: Activation of the human insulin receptor by non-insulin-related peptides Nat Commun, 13, 2022
7U6D	Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459 Descriptor: IM459, Isoform Short of Insulin receptor Authors: Kirk, N.S, Lawrence, M.C. Deposit date: 2022-03-03 Release date: 2022-10-05 Method: ELECTRON MICROSCOPY (5.03 Å) Cite: Activation of the human insulin receptor by non-insulin-related peptides Nat Commun, 13, 2022
6MOL	Monoextended DARPin M_R12 complex with EpoR Descriptor: Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12) Authors: Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. Deposit date: 2018-10-04 Release date: 2019-06-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.163 Å) Cite: Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
7U23	Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form Descriptor: Insulin-like growth factor 1 receptor, single-chain LCDV-1 viral insulin-like peptide Authors: Kirk, N.S, Lawrence, M.C. Deposit date: 2022-02-22 Release date: 2022-11-16 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist. Nat Commun, 13, 2022
4BK5	crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 (amine-methylated sample) Descriptor: EPHRIN TYPE-A RECEPTOR 4, EPHRIN-A5 Authors: Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. Deposit date: 2013-04-22 Release date: 2013-07-03 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (4 Å) Cite: Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
7V3P	Cryo-EM structure of the IGF1R/insulin complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... Authors: Zhang, J, Liu, C, Zhang, X, Wei, T, Wu, C. Deposit date: 2021-08-11 Release date: 2022-08-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Cryo-EM structure of the IGF1R/insulin complex To Be Published
5FMV	Crystal structure of human CD45 extracellular region, domains d1-d4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C, SULFATE ION Authors: Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. Deposit date: 2015-11-09 Release date: 2016-03-23 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'. Nat.Immunol., 17, 2016
5FN6	Crystal structure of human CD45 extracellular region, domains d1-d3 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C Authors: Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. Deposit date: 2015-11-10 Release date: 2016-03-23 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'. Nat.Immunol., 17, 2016
4BKF	crystal structure of the human EphA4 ectodomain in complex with human ephrinB3 Descriptor: EPHRIN TYPE-A RECEPTOR 4, EPHRIN-B3 Authors: Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. Deposit date: 2013-04-24 Release date: 2013-07-03 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (4.65 Å) Cite: Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
6NAJ	Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... Authors: van Agthoven, J, Arnaout, M.A. Deposit date: 2018-12-05 Release date: 2019-12-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure-guided design of pure orthosteric inhibitors of alpha IIb beta 3 that prevent thrombosis but preserve hemostasis. Nat Commun, 11, 2020
6MOF	Monomeric DARPin G2 complex with EpoR Descriptor: 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin Authors: Jude, K.M, Mohan, K, Garcia, K.C. Deposit date: 2018-10-04 Release date: 2019-06-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.894 Å) Cite: Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
5I99	Crystal structure of mouse CNTN3 Ig5-Fn2 domains Descriptor: Contactin-3, GLYCEROL Authors: Nikolaienko, R.M, Bouyain, S. Deposit date: 2016-02-19 Release date: 2016-08-31 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues. J.Biol.Chem., 291, 2016
4BK4	crystal structure of the human EphA4 ectodomain Descriptor: EPHRIN TYPE-A RECEPTOR 4 Authors: Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. Deposit date: 2013-04-22 Release date: 2013-07-03 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.65 Å) Cite: Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013

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