8SF7
 
 | | 48-nm doublet microtubule from Tetrahymena thermophila strain MEC17 | | Descriptor: | CFAM166A, CFAM166B, CFAM166C, ... | | Authors: | Black, C.S, Kubo, S, Yang, S.K, Bui, K.H. | | Deposit date: | 2023-04-10 | | Release date: | 2024-05-22 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Effect of alpha-tubulin acetylation on the doublet microtubule structure.
Elife, 12, 2024
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7B31
 | | MST3 in complex with compound MRIA9 | | Descriptor: | 1-[(5-azanyl-1,3-dioxan-2-yl)methyl]-3-[2-chloranyl-4-(3-fluoranylpyridin-2-yl)phenyl]-7-(methylamino)-1,6-naphthyridin-2-one, Serine/threonine-protein kinase 24 | | Authors: | Tesch, R, Rak, M, Joerger, A.C, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2020-11-28 | | Release date: | 2020-12-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.
J.Med.Chem., 64, 2021
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7RNG
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8QM1
 | | wild type Pa.FabF in complex cerulenin | | Descriptor: | (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, 3-oxoacyl-[acyl-carrier-protein] synthase 2, ... | | Authors: | Georgiou, C, Brenk, R, Espeland, L.O. | | Deposit date: | 2023-09-21 | | Release date: | 2024-01-10 | | Last modified: | 2025-05-07 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Towards new antibiotics: P. aeruginosa FabF ligands discovered by crystallographic fragment screening followed by hit expansion.
Eur.J.Med.Chem., 291, 2025
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7RNA
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5MFR
 | | The crystal structure of E. coli Aminopeptidase N in complex with 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one | | Descriptor: | Aminopeptidase N, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Peng, G, Olieric, V, McEwen, A.G, Schmitt, C, Albrecht, S, Cavarelli, J, Tarnus, C. | | Deposit date: | 2016-11-18 | | Release date: | 2017-04-19 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis.
Proteins, 85, 2017
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7AHL
 | | ALPHA-HEMOLYSIN FROM STAPHYLOCOCCUS AUREUS | | Descriptor: | ALPHA-HEMOLYSIN | | Authors: | Song, L, Hobaugh, M, Shustak, C, Cheley, S, Bayley, H, Gouaux, J.E. | | Deposit date: | 1996-12-02 | | Release date: | 1998-01-14 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore.
Science, 274, 1996
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5MGN
 | | Human Sirt6 in complex with activator UBCS38 | | Descriptor: | (4~{R})-4-pyridin-3-yl-5-[3-(trifluoromethyl)phenyl]sulfonyl-4~{H}-pyrrolo[1,2-a]quinoxaline, 1,2-ETHANEDIOL, NAD-dependent protein deacetylase sirtuin-6, ... | | Authors: | Steegborn, C, You, W, Kambach, C. | | Deposit date: | 2016-11-21 | | Release date: | 2016-12-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.
Angew. Chem. Int. Ed. Engl., 56, 2017
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7RX0
 | | Complex of AMPPNP-Kif7 and Gli2 Zinc-Finger domain bound to microtubules | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF7, MAGNESIUM ION, ... | | Authors: | Mani, N, Wilson-Kubalek, E.M, Haque, F, Freniere, C, Milligan, R.A, Subramanian, R. | | Deposit date: | 2021-08-20 | | Release date: | 2022-06-15 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.89 Å) | | Cite: | Cytoskeletal regulation of a transcription factor by DNA mimicry via coiled-coil interactions.
Nat.Cell Biol., 24, 2022
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4QY1
 | | Structure of H10 from human-infecting H10N8 in complex with avian receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wang, M, Zhang, W, Qi, J, Wang, F, Zhou, J, Bi, Y, Wu, Y, Sun, H, Liu, J, Huang, C, Li, X, Yan, J, Shu, Y, Shi, Y, Gao, G.F. | | Deposit date: | 2014-07-23 | | Release date: | 2015-01-28 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.594 Å) | | Cite: | Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus
Nat Commun, 6, 2015
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4QUR
 | | Crystal Structure of stachydrine demethylase in complex with cyanide, oxygen, and N-methyl proline in a new orientation | | Descriptor: | 1-methyl-L-proline, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, COBALT HEXAMMINE(III), ... | | Authors: | Agarwal, R, Andi, B, Gizzi, A, Bonanno, J.B, Almo, S.C, Orville, A.M. | | Deposit date: | 2014-07-11 | | Release date: | 2015-07-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.759 Å) | | Cite: | Tracking photoelectron induced in-crystallo enzyme catalysis
To be Published
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7S7B
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7PHR
 | | Structure of a fully assembled T-cell receptor engaging a tumor-associated peptide-MHC I | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | | Authors: | Susac, L, Thomas, C, Tampe, R. | | Deposit date: | 2021-08-18 | | Release date: | 2022-08-31 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.08 Å) | | Cite: | Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC.
Cell, 185, 2022
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7S7C
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7PK0
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4QX5
 | | Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: Insights for PKG agonist design | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, IODIDE ION, cGMP-dependent protein kinase 1 | | Authors: | Huang, G.Y, Gerlits, O.O, Blakeley, M.P, Sankaran, B, Kovalevsky, A.Y, Kim, C. | | Deposit date: | 2014-07-18 | | Release date: | 2014-11-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.318 Å) | | Cite: | Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design.
Biochemistry, 53, 2014
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1FRM
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7PKA
 | | Synechocystis sp. PCC6803 glutathione transferase Chi 1, GSOH bound | | Descriptor: | Glutathione S-transferase, POTASSIUM ION, S-Hydroxy-Glutathione | | Authors: | Didierjean, C, Mocchetti, E, Hecker, A, Favier, F. | | Deposit date: | 2021-08-25 | | Release date: | 2022-09-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Structure and functions of glutathione transferase Chi 1 from cyanobacterium Synechocystis sp. PCC 6803
To Be Published
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7ASG
 | | TGFBIp mutant R555W | | Descriptor: | Transforming growth factor-beta-induced protein ig-h3 | | Authors: | Nielsen, N.S, Gadeberg, T.A.F, Andersen, G.R. | | Deposit date: | 2020-10-27 | | Release date: | 2020-12-23 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Mutation-induced dimerization of transforming growth factor-beta-induced protein may drive protein aggregation in granular corneal dystrophy.
J.Biol.Chem., 297, 2021
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7E39
 | | SARS-CoV-2 spike in complex with the Ab4 neutralizing antibody (State 3) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Ab4, Light Chain of Ab4, ... | | Authors: | Liu, C. | | Deposit date: | 2021-02-08 | | Release date: | 2021-09-01 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants.
Cell Discov, 7, 2021
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7PK2
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7RVI
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7E3B
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7E3C
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7EBM
 | | W363A mutant of Chitin-specific solute binding protein from Vibrio harveyi in complex with chitobiose. | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Kitaoku, Y, Ubonbal, P, Tran, L.T, Robinson, R.C, Suginta, W. | | Deposit date: | 2021-03-10 | | Release date: | 2021-09-08 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A structural model for (GlcNAc) 2 translocation via a periplasmic chitooligosaccharide-binding protein from marine Vibrio bacteria.
J.Biol.Chem., 297, 2021
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