7PHR

Structure of a fully assembled T-cell receptor engaging a tumor-associated peptide-MHC I

Summary for 7PHR

• Entry DOI: 10.2210/pdb7phr/pdb
• EMDB information: 13427
• Descriptor: T-cell receptor alpha chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, T-cell receptor beta chain, ... (10 entities in total)
• Functional Keywords: t-cell receptor, tcr, major histocompatibility complex, mhc, antigen, adaptive immunity, cancer, complex, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 11
• Total formula weight: 202502.78

Authors

Susac, L.,Thomas, C.,Tampe, R. (deposition date: 2021-08-18, release date: 2022-08-31)

• Primary citation: Susac, L.,Vuong, M.T.,Thomas, C.,von Bulow, S.,O'Brien-Ball, C.,Santos, A.M.,Fernandes, R.A.,Hummer, G.,Tampe, R.,Davis, S.J.; Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC.; Cell, 185:3201-3213.e19, 2022; PubMed: 35985289; DOI: 10.1016/j.cell.2022.07.010

Experimental method

ELECTRON MICROSCOPY (3.08 Å)