1FFP
| CRYSTAL STRUCTURE OF MURINE CLASS I H-2DB COMPLEXED WITH PEPTIDE GP33 (C9M/K1S) | Descriptor: | BETA-2 MICROGLOBULIN BETA CHAIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B, ... | Authors: | Wang, B, Sharma, A, Maile, R, Saad, M, Collins, E.J, Frelinger, J.A. | Deposit date: | 2000-07-25 | Release date: | 2002-12-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Peptidic termini play a significant role in TCR recognition J.IMMUNOL., 169, 2002
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1JCR
| CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE NON-SUBSTRATE TETRAPEPTIDE INHIBITOR CVFM AND FARNESYL DIPHOSPHATE SUBSTRATE | Descriptor: | ACETIC ACID, FARNESYL DIPHOSPHATE, PROTEIN FARNESYLTRANSFERASE, ... | Authors: | Long, S.B, Casey, P.J, Beese, L.S. | Deposit date: | 2001-06-11 | Release date: | 2001-11-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc.Natl.Acad.Sci.USA, 98, 2001
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1JCQ
| CRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND THE PEPTIDOMIMETIC INHIBITOR L-739,750 | Descriptor: | 2(S)-{2(S)-[2(R)-AMINO-3-MERCAPTO]PROPYLAMINO-3(S)-METHYL}PENTYLOXY-3-PHENYLPROPIONYLMETHIONINE SULFONE, ACETIC ACID, FARNESYL DIPHOSPHATE, ... | Authors: | Long, S.B, Casey, P.J, Beese, L.S. | Deposit date: | 2001-06-11 | Release date: | 2001-11-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc.Natl.Acad.Sci.USA, 98, 2001
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1G9V
| HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXY HEMOGLOBIN COMPLEXED WITH A POTENT ALLOSTERIC EFFECTOR | Descriptor: | 2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID, HEMOGLOBIN ALPHA CHAIN, HEMOGLOBIN BETA CHAIN, ... | Authors: | Safo, M.K, Moure, C.M, Burnett, J.C, Joshi, G.S, Abraham, D.J. | Deposit date: | 2000-11-28 | Release date: | 2000-12-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | High-resolution crystal structure of deoxy hemoglobin complexed with a potent allosteric effector. Protein Sci., 10, 2001
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1JCS
| CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE PEPTIDE SUBSTRATE TKCVFM AND AN ANALOG OF FARNESYL DIPHOSPHATE | Descriptor: | ACETIC ACID, PROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT, ... | Authors: | Long, S.B, Casey, P.J, Beese, L.S. | Deposit date: | 2001-06-11 | Release date: | 2001-11-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc.Natl.Acad.Sci.USA, 98, 2001
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1PYE
| Crystal structure of CDK2 with inhibitor | Descriptor: | Cell division protein kinase 2, [2-AMINO-6-(2,6-DIFLUORO-BENZOYL)-IMIDAZO[1,2-A]PYRIDIN-3-YL]-PHENYL-METHANONE | Authors: | Zhang, F, Hamdouchi, C. | Deposit date: | 2003-07-08 | Release date: | 2004-07-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines. MOL.CANCER THER., 3, 2004
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1H23
| Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(12)-hupyridone at 2.15A resolution | Descriptor: | (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,12-DIAMINODODECANE DIHYDROCHLORIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE | Authors: | Wong, D.M, Greenblatt, H.M, Carlier, P.R, Han, Y.F, Pang, Y.P, Silman, I, Sussman, J.L. | Deposit date: | 2002-07-30 | Release date: | 2002-12-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity J.Am.Chem.Soc., 125, 2003
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1H87
| Gadolinium derivative of tetragonal Hen Egg-White Lysozyme at 1.7 A resolution | Descriptor: | 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID, CHLORIDE ION, GADOLINIUM ATOM, ... | Authors: | Girard, E, Chantalat, L, Vicat, J, Kahn, R. | Deposit date: | 2001-01-25 | Release date: | 2002-01-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Gd-Hp-Do3A, a Complex to Obtain High-Phasing-Power Heavy Atom Derivatives for Sad and MAD Experiments. Results with Tetragonal Hen Egg-White Lysozyme Acta Crystallogr.,Sect.D, 58, 2001
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1ODC
| STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-4'-QUINOLYL-N'-9"-(1",2",3",4"-TETRAHYDROACRIDINYL)-1,8- DIAMINOOCTANE AT 2.2A RESOLUTION | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, N-QUINOLIN-4-YL-N'-(1,2,3,4-TETRAHYDROACRIDIN-9-YL)OCTANE-1,8-DIAMINE | Authors: | Wong, D.M, Greenblatt, H.M, Carlier, P.R, Han, Y.-F, Pang, Y.-P, Silman, I, Sussman, J.L. | Deposit date: | 2003-02-15 | Release date: | 2005-03-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge. J.Med.Chem., 49, 2006
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1L4Z
| X-RAY CRYSTAL STRUCTURE OF THE COMPLEX OF MICROPLASMINOGEN WITH ALPHA DOMAIN OF STREPTOKINASE IN THE PRESENCE CADMIUM IONS | Descriptor: | CADMIUM ION, Plasminogen, Streptokinase | Authors: | Wakeham, N, Terzyan, S, Zhai, P, Loy, J.A, Tang, J, Zhang, X.C. | Deposit date: | 2002-03-06 | Release date: | 2002-12-11 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Effects of deletion of streptokinase residues 48-59 on plasminogen activation. PROTEIN ENG., 15, 2002
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1OQ5
| CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR | Descriptor: | 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE, Carbonic anhydrase II, ZINC ION | Authors: | Weber, A, Casini, A, Heine, A, Kuhn, D, Supuran, C.T, Scozzafava, A, Klebe, G. | Deposit date: | 2003-03-07 | Release date: | 2004-03-23 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition. J.Med.Chem., 47, 2004
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1GPQ
| Structure of ivy complexed with its target, HEWL | Descriptor: | INHIBITOR OF VERTEBRATE LYSOZYME, LYSOZYME C | Authors: | Abergel, C, Monchois, V, Claverie, J.-M. | Deposit date: | 2001-11-08 | Release date: | 2003-03-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure and Evolution of the Ivy Protein Family, Unexpected Lysozyme Inhibitors in Gram-Negative Bacteria. Proc.Natl.Acad.Sci.USA, 104, 2007
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1M8M
| SOLID-STATE MAS NMR STRUCTURE OF THE A-SPECTRIN SH3 DOMAIN | Descriptor: | SPECTRIN ALPHA CHAIN, BRAIN | Authors: | Castellani, F, Van Rossum, B, Diehl, A, Schubert, M, Rehbein, K, Oschkinat, H. | Deposit date: | 2002-07-25 | Release date: | 2002-11-20 | Last modified: | 2024-05-22 | Method: | SOLID-STATE NMR | Cite: | Structure of a protein determined by solid-state magic-angle-spinning NMR spectroscopy Nature, 420, 2002
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1H22
| Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(10)-hupyridone at 2.15A resolution | Descriptor: | (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,10-DIAMINODECANE DIHYDROCHLORIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE | Authors: | Wong, D.M, Greenblatt, H.M, Carlier, P.R, Han, Y.-F, Pang, Y.-P, Silman, I, Sussman, J.L. | Deposit date: | 2002-07-30 | Release date: | 2002-12-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity J.Am.Chem.Soc., 125, 2003
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1H6M
| Covalent glycosyl-enzyme intermediate of hen egg white lysozyme | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-deoxy-2-fluoro-alpha-D-glucopyranose, LYSOZYME C, SODIUM ION | Authors: | Vocadlo, D.J, Davies, G.J, Laine, R, Withers, S.G. | Deposit date: | 2001-06-19 | Release date: | 2001-08-30 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Catalysis by Hen Egg-White Lysozyme Proceeds Via a Covalent Intermediate Nature, 412, 2001
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1GWD
| Tri-iodide derivative of hen egg-white lysozyme | Descriptor: | 1,2-ETHANEDIOL, CARBON MONOXIDE, CHLORIDE ION, ... | Authors: | Evans, G, Bricogne, G. | Deposit date: | 2002-03-14 | Release date: | 2002-06-06 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Triiodide Derivatization and Combinatorial Counter-Ion Replacement: Two Methods for Enhancing Phasing Signal Using Laboratory Cu Kalpha X-Ray Equipment Acta Crystallogr.,Sect.D, 58, 2002
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1PQ3
| Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal | Descriptor: | Arginase II, mitochondrial precursor, CHLORIDE ION, ... | Authors: | Cama, E, Colleluori, D.M, Emig, F.A, Shin, H, Kim, S.W, Kim, N.N, Traish, A.M, Ash, D.E, Christianson, D.W. | Deposit date: | 2003-06-17 | Release date: | 2003-08-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal Biochemistry, 42, 2003
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1L4D
| CRYSTAL STRUCTURE OF MICROPLASMINOGEN-STREPTOKINASE ALPHA DOMAIN COMPLEX | Descriptor: | PLASMINOGEN, STREPTOKINASE, SULFATE ION | Authors: | Wakeham, N, Terzyan, S, Zhai, P, Loy, J.A, Tang, J, Zhang, X.C. | Deposit date: | 2002-03-04 | Release date: | 2002-12-11 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Effects of deletion of streptokinase residues 48-59 on plasminogen activation PROTEIN ENG., 15, 2002
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1HPZ
| HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 | Descriptor: | ALPHA-(2,6-DICHLOROPHENYL)-ALPHA-(2-ACETYL-5-METHYLANILINO)ACETAMIDE, POL POLYPROTEIN | Authors: | Ding, J, Hsiou, Y, Arnold, E. | Deposit date: | 2000-12-13 | Release date: | 2001-05-30 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J.Mol.Biol., 309, 2001
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1HQE
| HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 | Descriptor: | POL POLYPROTEIN | Authors: | Ding, J, Hsiou, Y, Arnold, E. | Deposit date: | 2000-12-15 | Release date: | 2001-05-30 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J.Mol.Biol., 309, 2001
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1NAV
| Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1 | Descriptor: | SULFATE ION, hormone receptor alpha 1, THRA1, ... | Authors: | Ye, L, Li, Y.L, Mellstrom, K, Mellin, C, Bladh, L.G, Koehler, K, Garg, N, Garcia Collazo, A.M, Litten, C, Husman, B, Persson, K, Ljunggren, J, Grover, G, Sleph, P.G, George, R, Malm, J. | Deposit date: | 2002-11-29 | Release date: | 2003-06-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1. J.Med.Chem., 46, 2003
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1HU9
| LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 4-HYDROPEROXY-2-METHOXY-PHENOL | Descriptor: | 4-HYDROPEROXY-2-METHOXY-PHENOL, FE (III) ION, LIPOXYGENASE-3 | Authors: | Zhou, K, Skrzypczak-Jankun, E, McCabe, N.P, Selman, S.H, Jankun, J. | Deposit date: | 2001-01-04 | Release date: | 2003-06-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of curcumin in complex with lipoxygenase and its significance in
cancer. INT.J.MOL.MED., 12, 2003
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1HQU
| HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 | Descriptor: | (S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-THIONE, POL POLYPROTEIN | Authors: | Hsiou, Y, Ding, J, Arnold, E. | Deposit date: | 2000-12-19 | Release date: | 2001-05-30 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J.Mol.Biol., 309, 2001
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1HQK
| CRYSTAL STRUCTURE ANALYSIS OF LUMAZINE SYNTHASE FROM AQUIFEX AEOLICUS | Descriptor: | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE | Authors: | Zhang, X, Meining, W, Fischer, M, Bacher, A, Ladenstein, R. | Deposit date: | 2000-12-18 | Release date: | 2001-12-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons. J.Mol.Biol., 306, 2001
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1HKN
| A complex between acidic fibroblast growth factor and 5-amino-2-naphthalenesulfonate | Descriptor: | 5-AMINO-NAPHTALENE-2-MONOSULFONATE, HEPARIN-BINDING GROWTH FACTOR 1 | Authors: | Fernandez-Tornero, C, Lozano, R.M, Gimenez-Gallego, G, Romero, A. | Deposit date: | 2003-03-10 | Release date: | 2004-03-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Leads for Development of New Naphthalenesulfonate Derivatives with Enhanced Antiangiogenic Activity: Crystal Structure of Acidic Fibroblast Growth Factor in Complex with 5-Amino-2-Naphthalenesulfonate J.Biol.Chem., 278, 2003
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