1NAV

Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1

Summary for 1NAV

Entry DOI	10.2210/pdb1nav/pdb
Related	1NAX
Descriptor	hormone receptor alpha 1, THRA1, SULFATE ION, {3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC ACID, ... (4 entities in total)
Functional Keywords	nuclear receptor, thyroid receptor, ligand, complex, membrane protein
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P10827
Total number of polymer chains	1
Total formula weight	30440.92
Authors	Ye, L.,Li, Y.L.,Mellstrom, K.,Mellin, C.,Bladh, L.G.,Koehler, K.,Garg, N.,Garcia Collazo, A.M.,Litten, C.,Husman, B.,Persson, K.,Ljunggren, J.,Grover, G.,Sleph, P.G.,George, R.,Malm, J. (deposition date: 2002-11-29, release date: 2003-06-17, Last modification date: 2024-02-14)
Primary citation	Ye, L.,Li, Y.L.,Mellstrom, K.,Mellin, C.,Bladh, L.G.,Koehler, K.,Garg, N.,Garcia Collazo, A.M.,Litten, C.,Husman, B.,Persson, K.,Ljunggren, J.,Grover, G.,Sleph, P.G.,George, R.,Malm, J. Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1. J.Med.Chem., 46:1580-1588, 2003 Cited by PubMed: 12699376 DOI: 10.1021/jm021080f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation