1NAV

Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 500

Chain	Residue
A	ARG157
A	HIS362
A	HOH701
A	HOH713

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site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE IH5 A 600

Chain	Residue
A	MET256
A	MET259
A	LEU276
A	SER277
A	GLY290
A	LEU292
A	ILE299
A	HIS381
A	MET388
A	PHE401
A	HOH725
A	HOH728
A	PHE218
A	THR219
A	ILE222
A	ALA225
A	ARG228

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:16781732, ECO:0007744|PDB:2H77, ECO:0007744|PDB:2H79

Chain	Residue	Details
A	ARG228

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:16781732, ECO:0007744|PDB:2H79

Chain	Residue	Details
A	SER277

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