1TQL
| POLIOVIRUS POLYMERASE G1A MUTANT | Descriptor: | ACETIC ACID, RNA-directed RNA polymerase | Authors: | Thompson, A.A, Peersen, O.B. | Deposit date: | 2004-06-17 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase Embo J., 23, 2004
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1NN8
| CryoEM structure of poliovirus receptor bound to poliovirus | Descriptor: | MYRISTIC ACID, coat protein VP1, coat protein VP2, ... | Authors: | He, Y, Mueller, S, Chipman, P.R, Bator, C.M, Peng, X, Bowman, V.D, Mukhopadhyay, S, Wimmer, E, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 2003-01-13 | Release date: | 2004-01-27 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (15 Å) | Cite: | Complexes of poliovirus serotypes with their common cellular receptor, CD155 J.Virol., 77, 2003
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1DGI
| Cryo-EM structure of human poliovirus(serotype 1)complexed with three domain CD155 | Descriptor: | POLIOVIRUS RECEPTOR, VP1, VP2, ... | Authors: | He, Y, Bowman, V.D, Mueller, S, Bator, C.M, Bella, J, Peng, X, Baker, T.S, Wimmer, E, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 1999-11-24 | Release date: | 2000-01-24 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (22 Å) | Cite: | Interaction of the poliovirus receptor with poliovirus. Proc.Natl.Acad.Sci.USA, 97, 2000
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1AR9
| P1/MAHONEY POLIOVIRUS, SINGLE SITE MUTANT H2142Y | Descriptor: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | Authors: | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | Deposit date: | 1997-08-11 | Release date: | 1997-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural studies of poliovirus mutants that overcome receptor defects. Nat.Struct.Biol., 4, 1997
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1AR6
| P1/MAHONEY POLIOVIRUS, DOUBLE MUTANT V1160I +P1095S | Descriptor: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | Authors: | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | Deposit date: | 1997-08-11 | Release date: | 1997-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural studies of poliovirus mutants that overcome receptor defects. Nat.Struct.Biol., 4, 1997
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1VBD
| POLIOVIRUS (TYPE 1, MAHONEY STRAIN) COMPLEXED WITH R78206 | Descriptor: | (METHYLPYRIDAZINE PIPERIDINE PROPYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID, POLIOVIRUS TYPE 1 MAHONEY | Authors: | Grant, R.A, Hiremath, C.N, Filman, D.J, Syed, R, Andries, K, Hogle, J.M. | Deposit date: | 1996-01-02 | Release date: | 1996-07-11 | Last modified: | 2023-04-19 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design. Curr.Biol., 4, 1994
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1XYR
| Poliovirus 135S cell entry intermediate | Descriptor: | Genome polyprotein, Coat protein VP1, Coat protein VP2, ... | Authors: | Bubeck, D, Filman, D.J, Cheng, N, Steven, A.C, Hogle, J.M, Belnap, D.M. | Deposit date: | 2004-11-10 | Release date: | 2005-08-02 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (11 Å) | Cite: | The structure of the poliovirus 135S cell entry intermediate at 10-angstrom resolution reveals the location of an externalized polypeptide that binds to membranes. J.Virol., 79, 2005
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1RA7
| Poliovirus Polymerase with GTP | Descriptor: | ACETIC ACID, GUANOSINE-5'-TRIPHOSPHATE, Genome polyprotein | Authors: | Thompson, A.A, Peersen, O.B. | Deposit date: | 2003-10-31 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase. Embo J., 23, 2004
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1RAJ
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1PO1
| POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R80633, AN INHIBITOR OF VIRAL REPLICATION | Descriptor: | (METHYLPYRIDAZINE PIPERIDINE BUTYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID, POLIOVIRUS TYPE 1 MAHONEY | Authors: | Hiremath, C.N, Filman, D.J, Grant, R.A, Hogle, J.M. | Deposit date: | 1997-01-08 | Release date: | 1997-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Ligand-induced conformational changes in poliovirus-antiviral drug complexes. Acta Crystallogr.,Sect.D, 53, 1997
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1POV
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1RA6
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1RDR
| POLIOVIRUS 3D POLYMERASE | Descriptor: | CALCIUM ION, POLIOVIRUS 3D POLYMERASE | Authors: | Hansen, J, Long, A, Schultz, S. | Deposit date: | 1998-04-28 | Release date: | 1998-09-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the RNA-dependent RNA polymerase of poliovirus. Structure, 5, 1997
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1PO2
| POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R77975, AN INHIBITOR OF VIRAL REPLICATION | Descriptor: | (METHYLPYRIDAZINE PIPERIDINE ETHYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID, POLIOVIRUS TYPE 1 MAHONEY | Authors: | Hiremath, C.N, Filman, D.J, Grant, R.A, Hogle, J.M. | Deposit date: | 1997-01-08 | Release date: | 1997-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Ligand-induced conformational changes in poliovirus-antiviral drug complexes. Acta Crystallogr.,Sect.D, 53, 1997
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1AL2
| P1/MAHONEY POLIOVIRUS, SINGLE SITE MUTANT V1160I | Descriptor: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | Authors: | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | Deposit date: | 1997-06-09 | Release date: | 1997-11-19 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural studies of poliovirus mutants that overcome receptor defects. Nat.Struct.Biol., 4, 1997
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1AR7
| P1/MAHONEY POLIOVIRUS, DOUBLE MUTANT P1095S + H2142Y | Descriptor: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | Authors: | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | Deposit date: | 1997-08-11 | Release date: | 1997-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural studies of poliovirus mutants that overcome receptor defects. Nat.Struct.Biol., 4, 1997
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1ASJ
| P1/MAHONEY POLIOVIRUS, AT CRYOGENIC TEMPERATURE | Descriptor: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | Authors: | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | Deposit date: | 1997-08-11 | Release date: | 1997-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural studies of poliovirus mutants that overcome receptor defects. Nat.Struct.Biol., 4, 1997
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1AR8
| P1/MAHONEY POLIOVIRUS, MUTANT P1095S | Descriptor: | MYRISTIC ACID, P1/MAHONEY POLIOVIRUS, SPHINGOSINE | Authors: | Wien, M.W, Curry, S, Filman, D.J, Hogle, J.M. | Deposit date: | 1997-08-11 | Release date: | 1997-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural studies of poliovirus mutants that overcome receptor defects. Nat.Struct.Biol., 4, 1997
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6XBU
| polymerase domain of polymerase-theta | Descriptor: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*GP*TP*CP*AP*TP*TP*G)-3'), DNA polymerase theta, ... | Authors: | Chen, X, Pomerantz, R, Zhao, J. | Deposit date: | 2020-06-07 | Release date: | 2021-06-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Pol theta reverse transcribes RNA and promotes RNA-templated DNA repair. Sci Adv, 7, 2021
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4X0P
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4X0Q
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7ZX0
| Crystal structure of Pol theta polymerase domain in complex with compound 5 | Descriptor: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[5-bromanyl-3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]oxy-~{N}-ethyl-~{N}-(3-methylphenyl)ethanamide, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), ... | Authors: | Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A. | Deposit date: | 2022-05-19 | Release date: | 2022-10-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta. J.Med.Chem., 65, 2022
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7ZUS
| Crystal structure of ternary complex of Pol theta polymerase domain | Descriptor: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), DNA (5'-D(P*TP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), ... | Authors: | Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A. | Deposit date: | 2022-05-13 | Release date: | 2022-10-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta. J.Med.Chem., 65, 2022
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7ZX1
| Crystal structure of Pol theta polymerase domain in complex with compound 22 | Descriptor: | (2~{S},3~{R})-1-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]-~{N}-methyl-~{N}-(3-methylphenyl)-3-oxidanyl-pyrrolidine-2-carboxamide, 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), ... | Authors: | Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A. | Deposit date: | 2022-05-19 | Release date: | 2022-10-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.829 Å) | Cite: | Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta. J.Med.Chem., 65, 2022
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9BH7
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