1PO2

POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R77975, AN INHIBITOR OF VIRAL REPLICATION

Summary for 1PO2
DescriptorPOLIOVIRUS TYPE 1 MAHONEY, (METHYLPYRIDAZINE PIPERIDINE ETHYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID, ... (7 entities in total)
Functional Keywordspoliovirus, picornavirus coat protein, anti-viral drugs, hydrolase, thiol protease, icosahedral virus, virus
Biological sourceHuman poliovirus 1
More
Cellular locationCapsid protein VP0: Virion. Capsid protein VP4: Virion. Capsid protein VP2: Virion. Capsid protein VP3: Virion. Capsid protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3AB: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Viral protein genome-linked: Virion. Protease 3C: Host cytoplasm. Protein 3CD: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03300 P03300 P03300
Total number of polymer chains5
Total formula weight98540.16
Authors
Hiremath, C.N.,Filman, D.J.,Grant, R.A.,Hogle, J.M. (deposition date: 1997-01-08, release date: 1997-12-03, Last modification date: 2017-11-29)
Primary citationFilman, D.J.,Grant, R.A.,Hiremath, C.N.,Hogle, J.M.
Ligand-induced conformational changes in poliovirus-antiviral drug complexes.
Acta Crystallogr.,Sect.D, 53:558-570, 1997
PubMed: 15299887
DOI: 110.1107/S0907444997000954
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation
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PDB entries from 2021-06-16