7ZX1
Crystal structure of Pol theta polymerase domain in complex with compound 22
This is a non-PDB format compatible entry.
Summary for 7ZX1
Entry DOI | 10.2210/pdb7zx1/pdb |
Descriptor | DNA polymerase theta, DNA (5'-D(P*TP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), ... (7 entities in total) |
Functional Keywords | dna polymerase, protein-dna complex, dna repair, inhibitor, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 18 |
Total formula weight | 548351.40 |
Authors | Krajewski, W.W.,Turnbull, A.P.,Willis, S.,Charles, M.,Stockley, M.,Heald, R.A. (deposition date: 2022-05-19, release date: 2022-10-12, Last modification date: 2024-01-31) |
Primary citation | Stockley, M.L.,Ferdinand, A.,Benedetti, G.,Blencowe, P.,Boyd, S.M.,Calder, M.,Charles, M.D.,Edwardes, L.V.,Ekwuru, T.,Finch, H.,Galbiati, A.,Geo, L.,Grande, D.,Grinkevich, V.,Holliday, N.D.,Krajewski, W.W.,MacDonald, E.,Majithiya, J.B.,McCarron, H.,McWhirter, C.L.,Patel, V.,Pedder, C.,Rajendra, E.,Ranzani, M.,Rigoreau, L.J.M.,Robinson, H.M.R.,Schaedler, T.,Sirina, J.,Smith, G.C.M.,Swarbrick, M.E.,Turnbull, A.P.,Willis, S.,Heald, R.A. Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta. J.Med.Chem., 65:13879-13891, 2022 Cited by PubMed: 36200480DOI: 10.1021/acs.jmedchem.2c01142 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.829 Å) |
Structure validation
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