PDB: 2435 resultsInfo pagesStatus searchChemie searchBIRD

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7RUO	Crystal structure of human UTP15 Descriptor: U3 small nucleolar RNA-associated protein 15 homolog, UNKNOWN ATOM OR ION Authors: Dehghani-Tafti, S, Dong, A, Zeng, H, Hutchinson, A, Seitova, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2021-08-17 Release date: 2021-11-10 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of human UTP15 To Be Published
6QTR	Crystal structure of a mutant Arabidopsis WD40 domain in complex with a transcription factor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTT	Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor homolog Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, MALONATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6WJQ	Crystal structure of WDR5 in complex with the WIN peptide of PDPK1 Descriptor: 3-phosphoinositide-dependent protein kinase 1, WD repeat-containing protein 5 Authors: Zhao, B, Fesik, S. Deposit date: 2020-04-14 Release date: 2021-01-13 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Crystal structure of WDR5 in complex with the WIN peptide of PDPK1 Cell Rep, 2021
6QTQ	Crystal structure of an Arabidopsis WD40 domain in complex with photoreceptor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTX	Crystal structure of an Arabidopsis WD40 domain in complex with a flowering transcription factor homolog Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2019-10-02 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTV	Crystal structure of an Arabidopsis WD40 domain in complex with an atypical bHLH transcription factor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, MALONATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTO	Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTW	Crystal structure of an Arabidopsis WD40 domain in complex with a blue light photoreceptor Descriptor: Cryptochrome-1, E3 ubiquitin-protein ligase COP1, GLYCEROL, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.39 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6YVI	EED in complex with a cyano-benzofuran Descriptor: 5-fluoranyl-4-[[[8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl]amino]methyl]-2,3-dihydro-1-benzofuran-7-carbonitrile, CALCIUM ION, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... Authors: Read, J.A. Deposit date: 2020-04-28 Release date: 2021-05-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase. Bioorg.Med.Chem.Lett., 39, 2021
6YVJ	EED in complex with a triazolopyrimidine Descriptor: GLYCEROL, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... Authors: Read, J.A. Deposit date: 2020-04-28 Release date: 2021-05-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase. Bioorg.Med.Chem.Lett., 39, 2021
7AXU	Structure of WDR5:CS-VIP8 cocrystal after illumination in situ Descriptor: WD repeat-containing protein 5 Authors: Werel, L, Essen, L.-O. Deposit date: 2020-11-10 Release date: 2021-11-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXQ	Structure of the cryo-trapped WDR5:CS-VIP8 cocrystal after illumination at 405 nm and 180 K Descriptor: CS-VIP8, WD repeat-containing protein 5 Authors: Werel, L, Essen, L.-O. Deposit date: 2020-11-10 Release date: 2021-12-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.562 Å) Cite: Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXX	Structure of WDR5:CS-VIP8 crystal after illumination at 405 nm and room temperature Descriptor: (ALQ)(4FO)R(ABA)(DPN)(EDN)(S7Z), WD repeat-containing protein 5 Authors: Werel, L, Essen, L.-O. Deposit date: 2020-11-10 Release date: 2021-12-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXP	Structural characterisation of WDR5:CS-VIP8 interaction in cis state 2 Descriptor: CS-VIP8, WD repeat-containing protein 5 Authors: Werel, L, Essen, L.-O. Deposit date: 2020-11-10 Release date: 2021-12-15 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.432 Å) Cite: Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXS	Structural characterisation of WDR5:CS-VIP8 interaction in cis state 1 Descriptor: CS-VIP8, (ALQ)(4FO)R(ABA)(DPN)(EDN)(S7Z), WD repeat-containing protein 5 Authors: Werel, L, Essen, L.-O. Deposit date: 2020-11-10 Release date: 2021-12-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
8D41	Crystal structure of the human COPB2 WD-domain in complex with OICR-6254 Descriptor: (1R,2R,3S,4S)-3-[4-(4-fluorophenyl)piperazine-1-carbonyl]bicyclo[2.2.1]heptane-2-carboxylic acid, Coatomer subunit beta', GLYCEROL, ... Authors: Zeng, H, Saraon, P, Dong, A, Hutchinson, A, Seitova, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2022-06-01 Release date: 2022-07-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the human COPB2 WD-domain in complex with OICR-6254 To Be Published
7U9Y	WDR5 bound to 2-(3,5-dimethoxybenzyl)-7-((2-methyl-1H-imidazol-1-yl)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one Descriptor: (5P)-2-[(3,5-dimethoxyphenyl)methyl]-7-[(2-methyl-1H-imidazol-1-yl)methyl]-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,4-dihydroisoquinolin-1(2H)-one, BENZAMIDINE, WD repeat-containing protein 5 Authors: Rietz, T. Deposit date: 2022-03-11 Release date: 2022-04-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J.Med.Chem., 65, 2022
8E9F	WD repeat-containing protein 5 complexed with 4-(7-((1H-imidazol-1-yl)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-ethyl-N-methylquinoline-8-carboxamide (compound 10) Descriptor: 6-ethyl-4-[(5P)-7-[(1H-imidazol-1-yl)methyl]-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl]-N-methylquinoline-8-carboxamide, BENZAMIDINE, WD repeat-containing protein 5 Authors: Rietz, T.A, Fesik, S.W. Deposit date: 2022-08-26 Release date: 2023-01-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models. Proc.Natl.Acad.Sci.USA, 120, 2023
7UAS	Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization Descriptor: (5P)-2-[(S)-cyclopropyl(4-methylpyridin-2-yl)methyl]-5-[1-ethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-[(2-methyl-1H-imidazol-1-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one, WD repeat-containing protein 5 Authors: Zhao, B. Deposit date: 2022-03-14 Release date: 2022-05-04 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.808 Å) Cite: Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J.Med.Chem., 65, 2022
8F1G	Crystal structure of human WDR5 in complex with compound WM662 Descriptor: (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, SULFATE ION, ... Authors: Liu, H. Deposit date: 2022-11-05 Release date: 2023-01-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. Acs Chem.Biol., 18, 2023
8F93	WDR5 covalently modified at Y228 by (R)-2-SF Descriptor: 3-ethynyl-5-{[(3R)-4-{1-[(2-methoxyphenyl)methyl]-1H-benzimidazole-5-carbonyl}-3-methylpiperazin-1-yl]methyl}benzene-1-sulfonyl fluoride, CHLORIDE ION, GLYCEROL, ... Authors: Taunton, J, Craven, G.B, Chen, Y. Deposit date: 2022-11-23 Release date: 2023-05-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat.Chem., 15, 2023
8EVL	Crystal structure of alpha-COPI N-terminal WD40 domain Descriptor: Putative coatomer subunit alpha Authors: Dey, D, Hasan, S.S. Deposit date: 2022-10-20 Release date: 2023-08-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8F0E	N-terminal WD40 domain of beta'-COPI subunit with four chains in the asymmetric unit Descriptor: Coatomer subunit beta' Authors: Dey, D, Hasan, S.S. Deposit date: 2022-11-02 Release date: 2023-08-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8SZX	Crystal structure of b'-WD40 Lys17Ala mutant Descriptor: Coatomer subunit beta' Authors: Dey, D, Hasan, S.S. Deposit date: 2023-05-30 Release date: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023

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