2W4S
| novel RNA-binding domain in Cryptosporidium parvum at 2.5 angstrom resolution | Descriptor: | Ankyrin-repeat protein | Authors: | Varrot, A, Mackereth, C, Mourao, A, Sattler, M, Cusack, S. | Deposit date: | 2008-12-02 | Release date: | 2009-12-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structure and RNA Recognition by the Snrna and Snorna Transport Factor Phax. RNA, 16, 2010
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2MV7
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5BK9
| AAD-1 Bound to the Vanadyl Ion and Succinate | Descriptor: | (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase, PHOSPHATE ION, SUCCINIC ACID, ... | Authors: | Ongpipattanakul, C, Chekan, J.R. | Deposit date: | 2019-06-01 | Release date: | 2019-06-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants. Proc.Natl.Acad.Sci.USA, 116, 2019
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5XMK
| Cryo-EM structure of the ATP-bound Vps4 mutant-E233Q complex with Vta1 (masked) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Vacuolar protein sorting-associated protein 4, Vacuolar protein sorting-associated protein VTA1 | Authors: | Sun, S, Li, L, Yang, F, Wang, X, Fan, F, Li, X, Wang, H, Sui, S. | Deposit date: | 2017-05-15 | Release date: | 2017-08-09 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Cryo-EM structures of the ATP-bound Vps4(E233Q) hexamer and its complex with Vta1 at near-atomic resolution Nat Commun, 8, 2017
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4FXA
| Crystal structure of the complex of Ribosome inactivating protein from Momordica balsamina with N-acetyl arginine at 1.7 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, N-ALPHA-L-ACETYL-ARGININE, ... | Authors: | Singh, A, Pandey, S, Kushwaha, G.S, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2012-07-03 | Release date: | 2012-07-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of the complex of Ribosome inactivating protein from Momordica balsamina with N-acetyl arginine at 1.7 Angstrom resolution To be Published
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4PSG
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2DCG
| MOLECULAR STRUCTURE OF A LEFT-HANDED DOUBLE HELICAL DNA FRAGMENT AT ATOMIC RESOLUTION | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*CP*G)-3'), MAGNESIUM ION, SPERMINE | Authors: | Wang, A.H.-J, Quigley, G.J, Kolpak, F.J, Crawford, J.L, Van Boom, J.H, Van Der Marel, G.A, Rich, A. | Deposit date: | 1988-08-29 | Release date: | 1989-01-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Molecular structure of a left-handed double helical DNA fragment at atomic resolution. Nature, 282, 1979
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2N9P
| Solution structure of RNF126 N-terminal zinc finger domain in complex with BAG6 Ubiquitin-like domain | Descriptor: | E3 ubiquitin-protein ligase RNF126, Large proline-rich protein BAG6, ZINC ION | Authors: | Martinez-Lumbreras, S, Krysztofinska, E.M, Thapaliya, A, Isaacson, R.L. | Deposit date: | 2015-12-01 | Release date: | 2016-05-25 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and functional insights into the E3 ligase, RNF126. Sci Rep, 6, 2016
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4PSP
| Crystal Structure of GH29 family alpha-L-fucosidase from Fusarium graminearum in the open form | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-fucosidase GH29, ... | Authors: | Cao, H, Walton, J, Brumm, P, Phillips Jr, G.N. | Deposit date: | 2014-03-07 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.561 Å) | Cite: | Structure and Substrate Specificity of a Eukaryotic Fucosidase from Fusarium graminearum. J.Biol.Chem., 289, 2014
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2VOR
| Crystal Structures of Mycobacterium tuberculosis Folylpolyglutamate Synthase Complexed with ADP and AMPPCP | Descriptor: | COBALT (II) ION, FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC, GLYCEROL, ... | Authors: | Young, P.G, Baker, E.N, Metcalf, P, Smith, C.A. | Deposit date: | 2008-02-19 | Release date: | 2008-07-01 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of Mycobacterium Tuberculosisfolylpolyglutamate Synthase Complexed with Adp and Amppcp. Acta Crystallogr.,Sect.D, 64, 2008
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6WZA
| Ni-bound structure of an engineered metal-dependent protein trimer, TriCyt1 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, HEME C, ... | Authors: | Tezcan, F.A, Kakkis, A. | Deposit date: | 2020-05-13 | Release date: | 2020-09-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Metal-Templated Design of Chemically Switchable Protein Assemblies with High-Affinity Coordination Sites. Angew.Chem.Int.Ed.Engl., 59, 2020
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5EQJ
| Crystal structure of the two-subunit tRNA m1A58 methyltransferase from Saccharomyces cerevisiae | Descriptor: | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 | Authors: | Zhu, Y, Wang, M, Wang, C, Fan, X, Jiang, X, Teng, M, Li, X. | Deposit date: | 2015-11-13 | Release date: | 2016-09-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae. Sci Rep, 6, 2016
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2MWX
| The RING Domain of human Promyelocytic Leukemia Protein (PML) | Descriptor: | Protein PML, ZINC ION | Authors: | Huang, S.Y, Chang, C.F, Fan, P.J, Guntert, P, Shih, H.M, Huang, T.H. | Deposit date: | 2014-12-02 | Release date: | 2015-02-11 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The RING domain of human promyelocytic leukemia protein (PML). J.Biomol.Nmr, 61, 2015
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4XDO
| Crystal structure of human KDM4C catalytic domain with OGA | Descriptor: | 1,2-ETHANEDIOL, FE (III) ION, Lysine-specific demethylase 4C, ... | Authors: | Swinger, K.K, Boriack-Sjodin, P.A. | Deposit date: | 2014-12-19 | Release date: | 2015-03-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening. J Biomol Screen, 20, 2015
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6X0Q
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7OD3
| SARS CoV-2 Spike protein, Bristol UK Deletion variant, Closed conformation, C3 symmetry | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, Spike glycoprotein | Authors: | Toelzer, C, Gupta, K, Yadav, S.K.N, Borucu, U, Schaffitzel, C, Berger, I. | Deposit date: | 2021-04-28 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2. Nat Commun, 13, 2022
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4G0J
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7NQO
| Mycobacterium tuberculosis Cytochrome P450 CYP121 in complex with lead compound 21 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[4-[2-(5-bromanyl-1~{H}-indol-3-yl)ethyl]pyrimidin-2-yl]morpholine, CHLORIDE ION, ... | Authors: | Selvam, I.R. | Deposit date: | 2021-03-01 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen). Eur.J.Med.Chem., 230, 2022
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7ODL
| SARS CoV-2 Spike protein, Bristol UK Deletion variant, Closed conformation, C1 symmetry | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, Spike glycoprotein | Authors: | Toelzer, C, Gupta, K, Yadav, S.K.N, Borucu, U, Schaffitzel, C, Berger, I. | Deposit date: | 2021-04-29 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2. Nat Commun, 13, 2022
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5ENM
| Compound 10 | Descriptor: | (2~{R},4~{S},6~{S})-4-[2,4-bis(fluoranyl)-5-pyrimidin-5-yl-phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-1,3-thiazinan-2-amine, Beta-secretase 1, GLYCEROL, ... | Authors: | Lewis, H.A. | Deposit date: | 2015-11-09 | Release date: | 2016-10-05 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain A beta Reduction in Rodents. Acs Med.Chem.Lett., 7, 2016
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5BNR
| E. coli Fabh with small molecule inhibitor 2 | Descriptor: | 1-{5-[2-fluoro-5-(hydroxymethyl)phenyl]pyridin-2-yl}piperidine-4-carboxylic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 3 | Authors: | Kazmirski, S.L, McKinney, D.C. | Deposit date: | 2015-05-26 | Release date: | 2016-05-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping. Acs Infect Dis., 2, 2016
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2N1R
| NMR Structure of the Myristylated Feline Immunodeficiency Virus Matrix Protein | Descriptor: | Matrix protein p15 | Authors: | Brown, L.A, Cox, C, Button, R.J, Baptiste, J, Bahlow, K, Spurrier, V, Luttge, B.G, Kuo, L, Freed, E.O, Summers, M.F, Kyser, J, Summers, H.R. | Deposit date: | 2015-04-15 | Release date: | 2015-05-27 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | NMR structure of the myristylated feline immunodeficiency virus matrix protein. Viruses, 7, 2015
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2DCE
| Solution structure of the SWIRM domain of human KIAA1915 protein | Descriptor: | KIAA1915 protein | Authors: | Yoneyama, M, Tochio, N, Umehara, T, Koshiba, S, Inoue, M, Tanaka, A, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-01-06 | Release date: | 2006-07-06 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural and Functional Differences of SWIRM Domain Subtypes J.Mol.Biol., 369, 2007
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5XSU
| novel orally efficacious inhibitors complexed with PARP1 | Descriptor: | 6-fluoranyl-2-(4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-yl)-1~{H}-benzimidazole-4-carboxamide, Poly [ADP-ribose] polymerase 1, SULFATE ION | Authors: | Liu, Q, Xu, Y. | Deposit date: | 2017-06-15 | Release date: | 2018-04-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors Eur J Med Chem, 145, 2018
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5ER7
| Connexin-26 Bound to Calcium | Descriptor: | CALCIUM ION, Gap junction beta-2 protein | Authors: | Purdy, M.D, Bennett, B.C, Baker, K.A, Yeager, M.J. | Deposit date: | 2015-11-13 | Release date: | 2016-01-27 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (3.286 Å) | Cite: | An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. Nat Commun, 7, 2016
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