5XSU

novel orally efficacious inhibitors complexed with PARP1

Summary for 5XSU

Entry DOI	10.2210/pdb5xsu/pdb
Descriptor	Poly [ADP-ribose] polymerase 1, SULFATE ION, 6-fluoranyl-2-(4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-yl)-1~{H}-benzimidazole-4-carboxamide, ... (4 entities in total)
Functional Keywords	complex structure, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P09874
Total number of polymer chains	4
Total formula weight	161059.21
Authors	Liu, Q.,Xu, Y. (deposition date: 2017-06-15, release date: 2018-04-25, Last modification date: 2023-11-22)
Primary citation	Chen, X.,Huan, X.,Liu, Q.,Wang, Y.,He, Q.,Tan, C.,Chen, Y.,Ding, J.,Xu, Y.,Miao, Z.,Yang, C. Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors Eur J Med Chem, 145:389-403, 2018 Cited by PubMed: 29335205 DOI: 10.1016/j.ejmech.2018.01.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation