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1O4R	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78783. Descriptor: (PHENYL-PHOSPHONO-METHYL)-PHOSPHONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O44	Crystal structure of sh2 in complex with ru85052 Descriptor: 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXY-PHENYL}-MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4C	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHOSPHATE. Descriptor: PHOSPHATE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4I	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PAS219. Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, cyclohexylmethyl 2-formylphenyl hydrogen (S)-phosphate Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O48	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85053. Descriptor: 5-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXYMETHYL-BENZOIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4O	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHENYLPHOSPHATE. Descriptor: PHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O46	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU90395. Descriptor: 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-METHOXYCARBONYL-PHENYL}-2-FLUORO-MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O41	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78300. Descriptor: 2-FORMYL-6-METHOXYPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O47	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82209. Descriptor: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-4-[DIFLUORO(PHOSPHONO)METHYL]PHENYLALANINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1NZL	Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYEpYIPI Descriptor: CHLORIDE ION, Doubly phosphorylated peptide ligand (PQpYEpYIPI), TETRAETHYLENE GLYCOL, ... Authors: Lubman, O.Y, Waksman, G. Deposit date: 2003-02-18 Release date: 2003-04-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and Thermodynamic Basis for the Interaction of the Src SH2 domain with the Activated form of the PDGF beta-receptor J.Mol.Biol., 328, 2003
1O4H	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79072. Descriptor: 2-CYANOQUINOLIN-8-YL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4L	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH FRAGMENT2. Descriptor: CITRIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1OO3	P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase Descriptor: Phosphatidylinositol 3-kinase regulatory alpha subunit Authors: Guenther, U.L, Weyrauch, B, Schaffhausen, B. Deposit date: 2003-03-03 Release date: 2003-03-25 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity Biochemistry, 42, 2003
1OO4	P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase complexed to a peptide derived from PDGFr Descriptor: 8-mer peptide from PDGFr, Phosphatidylinositol 3-kinase regulatory alpha subunit Authors: Guenther, U.L, Weyrauch, B, Schaffhausen, B. Deposit date: 2003-03-03 Release date: 2003-03-25 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity Biochemistry, 42, 2003
1P13	Crystal Structure of the Src SH2 Domain Complexed with Peptide (SDpYANFK) Descriptor: CACODYLATE ION, Peptide, Proto-oncogene tyrosine-protein kinase Src Authors: Sonnenburg, E.D, Bilwes, A, Hunter, T, Noel, J.P. Deposit date: 2003-04-11 Release date: 2003-08-19 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.63 Å) Cite: The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry, 42, 2003
1PIC	PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, NMR, MINIMIZED MEAN STRUCTURE Descriptor: BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE Authors: Breeze, A.L, Kara, B.V, Barratt, D.G, Anderson, M, Smith, J.C, Luke, R.W, Best, J.R, Cartlidge, S.A. Deposit date: 1997-06-23 Release date: 1997-09-17 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase. EMBO J., 15, 1996
1QAD	Crystal Structure of the C-Terminal SH2 Domain of the P85 alpha Regulatory Subunit of Phosphoinositide 3-Kinase: An SH2 domain mimicking its own substrate Descriptor: PI3-KINASE P85 ALPHA SUBUNIT Authors: Hoedemaeker, P.J, Siegal, G, Roe, M, Driscoll, P.C, Abrahams, J.P.A. Deposit date: 1999-02-26 Release date: 1999-10-27 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of the C-terminal SH2 domain of the p85alpha regulatory subunit of phosphoinositide 3-kinase: an SH2 domain mimicking its own substrate. J.Mol.Biol., 292, 1999
1QG1	GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH AN SHC-DERIVED PEPTIDE Descriptor: PROTEIN (GROWTH FACTOR RECEPTOR BINDING PROTEIN), PROTEIN (SHC-DERIVED PEPTIDE) Authors: Ogura, K. Deposit date: 1999-04-19 Release date: 1999-04-27 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide. J.Mol.Biol., 289, 1999
1R1Q	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads Descriptor: GRB2-related adaptor protein 2, LAT pY191 peptide, SULFATE ION Authors: Cho, S, Mariuzza, R.A. Deposit date: 2003-09-24 Release date: 2004-09-28 Last modified: 2018-04-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
1R1S	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads Descriptor: GRB2-related adaptor protein 2, LAT pY226 peptide, SULFATE ION Authors: Cho, S, Mariuzza, R.A. Deposit date: 2003-09-24 Release date: 2004-09-28 Last modified: 2018-04-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
1RJA	Solution Structure and Backbone Dynamics of the Nonreceptor Tyrosine Kinase PTK6/Brk SH2 Domain Descriptor: Tyrosine-protein kinase 6 Authors: Hong, E, Shin, J, Lee, W. Deposit date: 2003-11-18 Release date: 2004-07-20 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution Structure and Backbone Dynamics of the Non-receptor Protein-tyrosine Kinase-6 Src Homology 2 Domain J.Biol.Chem., 279, 2004
1R1P	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads Descriptor: GRB2-related adaptor protein 2, LAT pY171 peptide, SULFATE ION Authors: Cho, S, Mariuzza, R.A. Deposit date: 2003-09-24 Release date: 2004-09-28 Last modified: 2020-01-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
1RPY	CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS Descriptor: SULFATE ION, adaptor protein APS Authors: Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R. Deposit date: 2003-12-03 Release date: 2003-12-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol.Cell, 12, 2003
1SHB	CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES Descriptor: PHOSPHOPEPTIDE B, V-SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1992-08-18 Release date: 1993-10-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature, 358, 1992
1SHA	CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES Descriptor: PHOSPHOPEPTIDE A, V-SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1992-08-18 Release date: 1993-10-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature, 358, 1992

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