6D0M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6d0m by Molmil](/molmil-images/mine/6d0m) | Polymerase Eta post-insertion binary complex with cytarabine (AraC) | Descriptor: | DNA (5'-D(*CP*AP*TP*GP*AP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, DNA/RNA (5'-D(*AP*GP*CP*AP*CP*TP*GP*T)-R(P*(CAR))-3'), ... | Authors: | Rechkoblit, O, Aggarwal, A.K. | Deposit date: | 2018-04-10 | Release date: | 2018-09-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.832 Å) | Cite: | Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine. Sci Rep, 8, 2018
|
|
4ECZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ecz by Molmil](/molmil-images/mine/4ecz) | Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 6.5 (Na+ MES) with 1 Ca2+ ion | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Nakamura, T, Zhao, Y, Yang, W. | Deposit date: | 2012-03-26 | Release date: | 2012-07-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.834 Å) | Cite: | Watching DNA polymerase eta make a phosphodiester bond Nature, 487, 2012
|
|
7M87
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m87 by Molmil](/molmil-images/mine/7m87) | Human DNA Pol eta S113A with dA-ended primer and dATP: in crystallo reaction for 230 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7M8B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m8b by Molmil](/molmil-images/mine/7m8b) | Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 140 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7M7S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m7s by Molmil](/molmil-images/mine/7m7s) | Human DNA Pol eta S113A with dT-ended primer and 0.1 mM dAMPNPP | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-28 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7M8C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m8c by Molmil](/molmil-images/mine/7m8c) | Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 230 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
4J9L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4j9l by Molmil](/molmil-images/mine/4j9l) | Human DNA polymerase eta-DNA ternary complex: misincorporation G opposite T after a C at the primer 3' end (CA/G) | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA, DNA polymerase eta, ... | Authors: | Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W. | Deposit date: | 2013-02-16 | Release date: | 2013-05-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
4YP3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yp3 by Molmil](/molmil-images/mine/4yp3) | Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite an 8-Oxoguanine Lesion | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. | Deposit date: | 2015-03-12 | Release date: | 2015-05-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
|
|
4ECR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ecr by Molmil](/molmil-images/mine/4ecr) | Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 40 sec | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Nakamura, T, Zhao, Y, Yang, W. | Deposit date: | 2012-03-26 | Release date: | 2012-07-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.892 Å) | Cite: | Watching DNA polymerase eta make a phosphodiester bond Nature, 487, 2012
|
|
4ECW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ecw by Molmil](/molmil-images/mine/4ecw) | Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 250 sec | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Nakamura, T, Zhao, Y, Yang, W. | Deposit date: | 2012-03-26 | Release date: | 2012-07-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.896 Å) | Cite: | Watching DNA polymerase eta make a phosphodiester bond Nature, 487, 2012
|
|
5L9X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5l9x by Molmil](/molmil-images/mine/5l9x) | |
3MR6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mr6 by Molmil](/molmil-images/mine/3mr6) | Human DNA polymerase eta - DNA ternary complex with a CPD 2bp upstream of the active site (TT4) | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*C*AP*TP*CP*AP*(TTD)P*AP*CP*GP*AP*GP*C)-3'), DNA (5'-D(*TP*CP*TP*CP*GP*TP*AP*AP*T)-3'), ... | Authors: | Biertumpfel, C, Zhao, Y, Ramon-Maiques, S, Gregory, M.T, Lee, J.Y, Yang, W. | Deposit date: | 2010-04-28 | Release date: | 2010-06-30 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and mechanism of human DNA polymerase eta. Nature, 465, 2010
|
|
8V7B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v7b by Molmil](/molmil-images/mine/8v7b) | |
6MP3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mp3 by Molmil](/molmil-images/mine/6mp3) | |
7M8A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m8a by Molmil](/molmil-images/mine/7m8a) | Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 40 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7L69
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l69 by Molmil](/molmil-images/mine/7l69) | |
7M8D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m8d by Molmil](/molmil-images/mine/7m8d) | Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 300 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7M7U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m7u by Molmil](/molmil-images/mine/7m7u) | Human DNA Pol eta S113A with dT-ended primer and dATP: in crystallo reaction for 480s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-28 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
5L1J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5l1j by Molmil](/molmil-images/mine/5l1j) | |
4ECY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ecy by Molmil](/molmil-images/mine/4ecy) | Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 6.0 (Na+ MES) with 1 Ca2+ ion | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Nakamura, T, Zhao, Y, Yang, W. | Deposit date: | 2012-03-26 | Release date: | 2012-07-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.943 Å) | Cite: | Watching DNA polymerase eta make a phosphodiester bond Nature, 487, 2012
|
|
4ECU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ecu by Molmil](/molmil-images/mine/4ecu) | Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 200 sec | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Nakamura, T, Zhao, Y, Yang, W. | Deposit date: | 2012-03-26 | Release date: | 2012-07-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.949 Å) | Cite: | Watching DNA polymerase eta make a phosphodiester bond Nature, 487, 2012
|
|
8V7A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v7a by Molmil](/molmil-images/mine/8v7a) | |
8V7D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v7d by Molmil](/molmil-images/mine/8v7d) | |
4J9S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4j9s by Molmil](/molmil-images/mine/4j9s) | Human DNA polymerase eta-DNA translocated binary complex: with TA base pair | Descriptor: | DNA (5'-D(*T*AP*TP*TP*TP*AP*TP*GP*AP*CP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*GP*TP*CP*AP*TP*A)-3'), DNA polymerase eta, ... | Authors: | Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W. | Deposit date: | 2013-02-16 | Release date: | 2013-05-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
4YR2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yr2 by Molmil](/molmil-images/mine/4yr2) | Mutant Human DNA Polymerase Eta R61M Inserting dATP Opposite an 8-Oxoguanine Lesion | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. | Deposit date: | 2015-03-14 | Release date: | 2015-05-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
|
|