5W96
 
 | | Solution structure of phage derived peptide inhibitor of frizzled 7 receptor | | 分子名称: | Fz7 binding peptide | | 著者 | Nile, A.H, de Sousa e Melo, F, Mukund, S, Piskol, R, Hansen, S, Zhou, L, Zhang, Y, Fu, Y, Gogol, E.B, Komuves, L.G, Modrusan, Z, Angers, S, Franke, Y, Koth, C, Fairbrother, W.J, Wang, W, de Sauvage, F.J, Hannoush, R.N. | | 登録日 | 2017-06-22 | | 公開日 | 2018-04-18 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nat. Chem. Biol., 14, 2018
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4EAI
 | | Co-crystal structure of an AMPK core with AMP | | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | | 著者 | Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W. | | 登録日 | 2012-03-22 | | 公開日 | 2012-06-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.285 Å) | | 主引用文献 | AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
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4EAK
 | | Co-crystal structure of an AMPK core with ATP | | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | | 著者 | Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W. | | 登録日 | 2012-03-22 | | 公開日 | 2012-06-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
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3SOQ
 | | The structure of the first YWTD beta propeller domain of LRP6 in complex with a DKK1 peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Dickkopf-related protein 1, ... | | 著者 | Wang, W, Bourhis, E, Zhang, Y, Rouge, L, Wu, Y, Franke, Y, Cochran, A.G. | | 登録日 | 2011-06-30 | | 公開日 | 2011-09-21 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Structure, 19, 2011
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6LJA
 | | Crystal Structure of exoHep from Bacteroides intestinalis DSM 17393 complexed with disaccharide product | | 分子名称: | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, Heparinase II/III-like protein | | 著者 | Zhang, Q.D, Cao, H.Y, Wei, L, Li, F.C, Zhang, Y.Z. | | 登録日 | 2019-12-13 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.978 Å) | | 主引用文献 | Discovery of exolytic heparinases and their catalytic mechanism and potential application.
Nat Commun, 12, 2021
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6DAN
 | | PhdJ WT 2 Angstroms resolution | | 分子名称: | CHLORIDE ION, PhdJ | | 著者 | Medellin, B.P, LeVieux, J.A, Zhang, Y.J, Whitman, C.P. | | 登録日 | 2018-05-01 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.047 Å) | | 主引用文献 | Structural Characterization of the Hydratase-Aldolases, NahE and PhdJ: Implications for the Specificity, Catalysis, and N-Acetylneuraminate Lyase Subgroup of the Aldolase Superfamily.
Biochemistry, 57, 2018
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3KVM
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3KVL
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3KVK
 | | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 641 at 2.05A resolution | | 分子名称: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, 2-{[(3,5-dichlorophenyl)carbamoyl]amino}benzoic acid, Dihydroorotate dehydrogenase, ... | | 著者 | McLean, L, Zhang, Y. | | 登録日 | 2009-11-30 | | 公開日 | 2010-03-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures.
Bioorg.Med.Chem.Lett., 20, 2010
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3KVJ
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6OSA
 | | human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation (NC state) | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Kato, H.E, Zhang, Y, Kobilka, B.K, Skiniotis, G. | | 登録日 | 2019-05-01 | | 公開日 | 2019-07-10 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Conformational transitions of a neurotensin receptor 1-Gi1complex.
Nature, 572, 2019
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6OS9
 | | human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Kato, H.E, Zhang, Y, Kobilka, B.K, Skiniotis, G. | | 登録日 | 2019-05-01 | | 公開日 | 2019-07-10 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Conformational transitions of a neurotensin receptor 1-Gi1complex.
Nature, 572, 2019
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6DDE
 | | Mu Opioid Receptor-Gi Protein Complex | | 分子名称: | DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Koehl, A, Hu, H, Maeda, S, Manglik, A, Zhang, Y, Kobilka, B.K, Skiniotis, G, Weis, W.I. | | 登録日 | 2018-05-10 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
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6PWW
 | | Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome | | 分子名称: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | | 登録日 | 2019-07-23 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Nat Commun, 10, 2019
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6PWX
 | | Cryo-EM structure of RbBP5 bound to the nucleosome | | 分子名称: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | | 登録日 | 2019-07-23 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Nat Commun, 10, 2019
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6PWV
 | | Cryo-EM structure of MLL1 core complex bound to the nucleosome | | 分子名称: | DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... | | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | | 登録日 | 2019-07-23 | | 公開日 | 2019-12-18 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Nat Commun, 10, 2019
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3SZF
 | | Crystal structure of sulfide:quinone oxidoreductase H198A variant from Acidithiobacillus ferrooxidans in complex with bound trisulfide and decylubiquinone | | 分子名称: | 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, DODECYL-BETA-D-MALTOSIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Cherney, M.M, Zhang, Y, James, M.N.G, Weiner, J.H. | | 登録日 | 2011-07-18 | | 公開日 | 2012-05-16 | | 最終更新日 | 2014-05-07 | | 実験手法 | X-RAY DIFFRACTION (2.0994 Å) | | 主引用文献 | Structure-activity characterization of sulfide:quinone oxidoreductase variants.
J.Struct.Biol., 178, 2012
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3SZW
 | | Crystal structure of sulfide:quinone oxidoreductase Cys128Ser variant from Acidithiobacillus ferrooxidans in complex with decylubiquinone | | 分子名称: | 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, DODECYL-BETA-D-MALTOSIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Cherney, M.M, Zhang, Y, James, M.N.G, Weiner, J.H. | | 登録日 | 2011-07-19 | | 公開日 | 2012-05-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure-activity characterization of sulfide:quinone oxidoreductase variants.
J.Struct.Biol., 178, 2012
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3SX6
 | | Crystal structure of sulfide:quinone oxidoreductase Cys356Ala variant from Acidithiobacillus ferrooxidans complexed with decylubiquinone | | 分子名称: | 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, DODECYL-BETA-D-MALTOSIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Cherney, M.M, Zhang, Y, James, M.N.G, Weiner, J.H. | | 登録日 | 2011-07-14 | | 公開日 | 2012-05-16 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.7955 Å) | | 主引用文献 | Structure-activity characterization of sulfide:quinone oxidoreductase variants.
J.Struct.Biol., 178, 2012
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3T2Z
 | | Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans | | 分子名称: | 1,3-BUTANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, HYDROSULFURIC ACID, ... | | 著者 | Cherney, M.M, Zhang, Y, Solomonson, M, Weiner, J.H, James, M.N. | | 登録日 | 2011-07-23 | | 公開日 | 2011-08-17 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.2994 Å) | | 主引用文献 | Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans: insights into sulfidotrophic respiration and detoxification.
J.Mol.Biol., 398, 2010
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3SXI
 | | Crystal structure of sulfide:quinone oxidoreductase Cys128Ala variant from Acidithiobacillus ferrooxidans complexed with decylubiquinone | | 分子名称: | 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, DODECYL-BETA-D-MALTOSIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Cherney, M.M, Zhang, Y, James, M.N.G, Weiner, J.H. | | 登録日 | 2011-07-14 | | 公開日 | 2012-05-16 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1792 Å) | | 主引用文献 | Structure-activity characterization of sulfide:quinone oxidoreductase variants.
J.Struct.Biol., 178, 2012
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3T31
 | | Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans in complex with decylubiquinone | | 分子名称: | 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, DODECYL-BETA-D-MALTOSIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Cherney, M.M, Zhang, Y, Solomonson, M, Weiner, J.H, James, M.N. | | 登録日 | 2011-07-24 | | 公開日 | 2011-08-17 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans: insights into sulfidotrophic respiration and detoxification.
J.Mol.Biol., 398, 2010
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3T0K
 | | Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans with bound trisulfide and decylubiquinone | | 分子名称: | 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, FLAVIN-ADENINE DINUCLEOTIDE, HYDROSULFURIC ACID, ... | | 著者 | Cherney, M.M, Zhang, Y, James, M.N.G, Weiner, J.H. | | 登録日 | 2011-07-20 | | 公開日 | 2012-05-16 | | 最終更新日 | 2014-05-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-activity characterization of sulfide:quinone oxidoreductase variants.
J.Struct.Biol., 178, 2012
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3SZ0
 | | Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans in complex with sodium selenide | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FLAVIN-ADENINE DINUCLEOTIDE, SELENIUM ATOM, ... | | 著者 | Cherney, M.M, Zhang, Y, James, M.N.G, Weiner, J.H. | | 登録日 | 2011-07-18 | | 公開日 | 2012-05-16 | | 最終更新日 | 2012-07-25 | | 実験手法 | X-RAY DIFFRACTION (2.1501 Å) | | 主引用文献 | Structure-activity characterization of sulfide:quinone oxidoreductase variants.
J.Struct.Biol., 178, 2012
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8YUU
 | | Cryo-EM structure of the histamine-bound H3R-Gi complex | | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | | 登録日 | 2024-03-27 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.
Adv Sci, 11, 2024
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