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PDB: 225 results

5UOT
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BU of 5uot by Molmil
CryoEM structure of the helical assembly of full length MxB
Descriptor: Interferon-induced GTP-binding protein Mx2
Authors:Perilla, J.R, Alvarez, F.J.D, Zhang, P, Schulten, K.
Deposit date:2017-02-01
Release date:2018-02-21
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction.
Sci Adv, 3, 2017
8FEC
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BU of 8fec by Molmil
Structure of J-PKAc chimera complexed with Aplithianine derivative
Descriptor: 6-[(6P)-6-(4-bromo-1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-7H-purine, DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha
Authors:Du, L, Wilson, B.A.P, Li, N, Martinez Fiesco, J.A, Dalilian, M, Wang, D, Smith, E.A, Wamiru, A, Goncharova, E.I, Zhang, P, O'Keefe, B.R.
Deposit date:2022-12-06
Release date:2023-10-18
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases.
J.Nat.Prod., 86, 2023
8FE2
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Structure of J-PKAc chimera complexed with Aplithianine A
Descriptor: 6-[(6M)-6-(1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-9H-purine, DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha, ...
Authors:Du, L, Wilson, B.A.P, Li, N, Dalilian, M, Wang, D, Martinez Fiesco, J.A, Smith, E.A, Wamiru, A, Goncharova, E.I, Zhang, P, O'Keefe, B.R.
Deposit date:2022-12-05
Release date:2023-10-18
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases.
J.Nat.Prod., 86, 2023
3E9G
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BU of 3e9g by Molmil
Crystal structure long-form (residue1-124) of Eaf3 chromo domain
Descriptor: Chromatin modification-related protein EAF3
Authors:Sun, B, Hong, J, Zhang, P, Lin, D, Ding, J.
Deposit date:2008-08-22
Release date:2008-11-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Basis of the Interaction of Saccharomyces cerevisiae Eaf3 Chromo Domain with Methylated H3K36
J.Biol.Chem., 283, 2008
5V6I
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BU of 5v6i by Molmil
Glycan binding protein Y3 from mushroom Coprinus comatus possesses anti-leukemic activity - Pt derivative
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CHLORIDE ION, PLATINUM (II) ION, ...
Authors:Li, K, Zhang, P, Gang, Y, Xia, C, Polston, J.E, Li, G, Li, S, Lin, Z, Yang, L.-J, Bruner, S.D, Ding, Y.
Deposit date:2017-03-16
Release date:2017-08-16
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Cytotoxic protein from the mushroom Coprinus comatus possesses a unique mode for glycan binding and specificity.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8A1S
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BU of 8a1s by Molmil
Structure of murine perforin-2 (Mpeg1) pore in twisted form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Yu, X, Ni, T, Zhang, P, Gilbert, R.
Deposit date:2022-06-02
Release date:2022-07-20
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation.
Embo J., 41, 2022
8A1D
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Structure of murine perforin-2 (Mpeg1) pore in ring form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, Macrophage-expressed gene 1 protein
Authors:Yu, X, Ni, T, Zhang, P, Gilbert, R.
Deposit date:2022-06-01
Release date:2022-07-20
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation.
Embo J., 41, 2022
7CX4
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BU of 7cx4 by Molmil
Cryo-EM structure of the Evatanepag-bound EP2-Gs complex
Descriptor: 2-[3-[[(4-~{tert}-butylphenyl)methyl-pyridin-3-ylsulfonyl-amino]methyl]phenoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Qu, C, Mao, C, Xiao, P, Shen, Q, Zhong, Y, Yang, F, Shen, D, Tao, X, Zhang, H, Yan, X, Zhao, R, He, J, Guan, Y, Zhang, C, Hou, G, Zhang, P, Yu, X, Guan, Y, Sun, J, Zhang, Y.
Deposit date:2020-09-01
Release date:2021-05-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype.
Sci Adv, 7, 2021
7CX3
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BU of 7cx3 by Molmil
Cryo-EM structure of the Taprenepag-bound EP2-Gs complex
Descriptor: 2-[3-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonyl-amino]methyl]phenoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Qu, C, Mao, C, Xiao, P, Shen, Q, Zhong, Y, Yang, F, Shen, D, Tao, X, Zhang, H, Yan, X, Zhao, R, He, J, Guan, Y, Zhang, C, Hou, G, Zhang, P, Yu, X, Guan, Y, Sun, J, Zhang, Y.
Deposit date:2020-09-01
Release date:2021-05-05
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype.
Sci Adv, 7, 2021
7CX2
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Cryo-EM structure of the PGE2-bound EP2-Gs complex
Descriptor: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Qu, C, Mao, C, Xiao, P, Shen, Q, Zhong, Y, Yang, F, Shen, D, Tao, X, Zhang, H, Yan, X, Zhao, R, He, J, Guan, Y, Zhang, C, Hou, G, Zhang, P, Yu, X, Guan, Y, Sun, J, Zhang, Y.
Deposit date:2020-09-01
Release date:2021-05-05
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype.
Sci Adv, 7, 2021
5V6J
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BU of 5v6j by Molmil
Glycan binding protein Y3 from mushroom Coprinus comatus possesses anti-leukemic activity
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, TMV resistance protein Y3
Authors:Li, K, Zhang, P, Gang, Y, Xia, C, Polston, J.E, Li, G, Li, S, Lin, Z, Yang, L.-J, Bruner, S.D, Ding, Y.
Deposit date:2017-03-16
Release date:2017-08-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Cytotoxic protein from the mushroom Coprinus comatus possesses a unique mode for glycan binding and specificity.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3E9F
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BU of 3e9f by Molmil
Crystal structure short-form (residue1-113) of Eaf3 chromo domain
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Chromatin modification-related protein EAF3
Authors:Sun, B, Hong, J, Zhang, P, Lin, D, Ding, J.
Deposit date:2008-08-22
Release date:2008-11-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis of the Interaction of Saccharomyces cerevisiae Eaf3 Chromo Domain with Methylated H3K36
J.Biol.Chem., 283, 2008
3S32
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BU of 3s32 by Molmil
Crystal structure of Ash2L N-terminal domain
Descriptor: Set1/Ash2 histone methyltransferase complex subunit ASH2, ZINC ION
Authors:Sarvan, S, Avdic, V, Tremblay, V, Chaturvedi, C.-P, Zhang, P, Lanouette, S, Blais, A, Brunzelle, J.S, Brand, M, Couture, J.-F.
Deposit date:2011-05-17
Release date:2011-06-08
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain.
Nat.Struct.Mol.Biol., 18, 2011
8FY0
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BU of 8fy0 by Molmil
E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL)
Descriptor: Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ...
Authors:Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D.
Deposit date:2023-01-25
Release date:2024-04-10
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
8FY1
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BU of 8fy1 by Molmil
E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2)
Descriptor: Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ...
Authors:Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K.
Deposit date:2023-01-25
Release date:2024-04-10
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
8FY2
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BU of 8fy2 by Molmil
E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2)
Descriptor: Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ...
Authors:Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K.
Deposit date:2023-01-25
Release date:2024-04-10
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
6K9K
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BU of 6k9k by Molmil
Monomeric human ATM (Ataxia telangiectasia mutated) kinase
Descriptor: Serine-protein kinase ATM
Authors:Xiao, J, Liu, M, Qi, Y, Yuriy, C, Zhang, P, Xu, Y.
Deposit date:2019-06-16
Release date:2019-12-25
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (7.82 Å)
Cite:Structural insights into the activation of ATM kinase.
Cell Res., 29, 2019
7E1B
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BU of 7e1b by Molmil
Crystal structure of VbrR-DNA complex
Descriptor: DNA (26-MER), DNA-binding response regulator
Authors:Hong, S, Zhang, X, Zhang, P.
Deposit date:2021-02-01
Release date:2022-02-09
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (4.587 Å)
Cite:Structural basis of phosphorylation-induced activation of the response regulator VbrR.
Acta Biochim.Biophys.Sin., 2023
7EGK
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BU of 7egk by Molmil
Bicarbonate transporter complex SbtA-SbtB bound to AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Membrane-associated protein SbtB, SODIUM ION, ...
Authors:Fang, S, Huang, X, Zhang, X, Zhang, P.
Deposit date:2021-03-24
Release date:2021-05-26
Last modified:2021-06-16
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Molecular mechanism underlying transport and allosteric inhibition of bicarbonate transporter SbtA.
Proc.Natl.Acad.Sci.USA, 118, 2021
7E1H
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BU of 7e1h by Molmil
crystal structure of RD-BEF
Descriptor: BERYLLIUM TRIFLUORIDE ION, DNA-binding response regulator, MAGNESIUM ION
Authors:Hong, S, Zhang, X, Zhang, P.
Deposit date:2021-02-01
Release date:2022-02-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.805 Å)
Cite:Structural basis of phosphorylation-induced activation of the response regulator VbrR.
Acta Biochim.Biophys.Sin., 2023
7CSD
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BU of 7csd by Molmil
AtPrR1 with NADP+ and (+)lariciresinol
Descriptor: 4-[[(3R,4R,5S)-4-(hydroxymethyl)-5-(3-methoxy-4-oxidanyl-phenyl)oxolan-3-yl]methyl]-2-methoxy-phenol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol reductase 1
Authors:Shao, K, Zhang, P.
Deposit date:2020-08-14
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.79709971 Å)
Cite:Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
7CSF
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BU of 7csf by Molmil
AtPrR1 with NADP+ and (-)secoisolariciresinol
Descriptor: (2R,3R)-2,3-bis[(3-methoxy-4-oxidanyl-phenyl)methyl]butane-1,4-diol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol reductase 1
Authors:Shao, K, Zhang, P.
Deposit date:2020-08-14
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.98241806 Å)
Cite:Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
7CSB
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BU of 7csb by Molmil
AtPrR1 with NADP+ and (+)pinoresinol
Descriptor: 4-[(3S,3aR,6S,6aR)-6-(3-methoxy-4-oxidanyl-phenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxy-phenol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol reductase 1
Authors:Shao, K, Zhang, P.
Deposit date:2020-08-14
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.002017 Å)
Cite:Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
7CS6
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BU of 7cs6 by Molmil
IiPLR1 with NADP+ and (-)lariciresinol
Descriptor: 4-[[(3S,4S,5R)-4-(hydroxymethyl)-5-(3-methoxy-4-oxidanyl-phenyl)oxolan-3-yl]methyl]-2-methoxy-phenol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol-lariciresinol reductase
Authors:Shao, K, Zhang, P.
Deposit date:2020-08-14
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.20139647 Å)
Cite:Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
7CS8
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BU of 7cs8 by Molmil
IiPLR1 with NADP+ and (-)secoisolariciresinol
Descriptor: (2R,3R)-2,3-bis[(3-methoxy-4-oxidanyl-phenyl)methyl]butane-1,4-diol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol-lariciresinol reductase
Authors:Shao, K, Zhang, P.
Deposit date:2020-08-14
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.60003257 Å)
Cite:Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021

222036

PDB entries from 2024-07-03

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