5DC7
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![BU of 5dc7 by Molmil](/molmil-images/mine/5dc7) | Crystal structure of D176A-Y306F HDAC8 in complex with a tetrapeptide substrate | 分子名称: | Fluor-de-Lys tetrapeptide assay substrate, GLYCEROL, Histone deacetylase 8, ... | 著者 | Decroos, C, Lee, M.S, Christianson, D.W. | 登録日 | 2015-08-23 | 公開日 | 2016-02-03 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry, 55, 2016
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3ITB
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![BU of 3itb by Molmil](/molmil-images/mine/3itb) | Crystal structure of Penicillin-Binding Protein 6 (PBP6) from E. coli in complex with a substrate fragment | 分子名称: | D-alanyl-D-alanine carboxypeptidase DacC, Peptidoglycan substrate (AMV)A(FGA)K(DAL)(DAL), SULFATE ION, ... | 著者 | Chen, Y, Zhang, W, Shi, Q, Hesek, D, Lee, M, Mobashery, S, Shoichet, B.K. | 登録日 | 2009-08-27 | 公開日 | 2009-10-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structures of penicillin-binding protein 6 from Escherichia coli. J.Am.Chem.Soc., 131, 2009
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5DC6
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![BU of 5dc6 by Molmil](/molmil-images/mine/5dc6) | Crystal structure of D176N-Y306F HDAC8 in complex with a tetrapeptide substrate | 分子名称: | Fluor-de-Lys tetrapeptide assay substrate, GLYCEROL, Histone deacetylase 8, ... | 著者 | Decroos, C, Lee, M.S, Christianson, D.W. | 登録日 | 2015-08-23 | 公開日 | 2016-02-03 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.553 Å) | 主引用文献 | General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry, 55, 2016
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5DC8
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![BU of 5dc8 by Molmil](/molmil-images/mine/5dc8) | Crystal structure of H142A-Y306F HDAC8 in complex with a tetrapeptide substrate | 分子名称: | Fluor-de-Lys tetrapeptide assay substrate, GLYCEROL, Histone deacetylase 8, ... | 著者 | Decroos, C, Lee, M.S, Christianson, D.W. | 登録日 | 2015-08-23 | 公開日 | 2016-02-03 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry, 55, 2016
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7CV2
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![BU of 7cv2 by Molmil](/molmil-images/mine/7cv2) | Crystal structure of B. halodurans NiaR in niacin-bound form | 分子名称: | NICOTINIC ACID, Transcriptional regulator NiaR, ZINC ION | 著者 | Lee, J.Y, Lee, D.W, Park, Y.W, Lee, M.Y, Jeong, K.H. | 登録日 | 2020-08-25 | 公開日 | 2020-12-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | 主引用文献 | Structural analysis and insight into effector binding of the niacin-responsive repressor NiaR from Bacillus halodurans. Sci Rep, 10, 2020
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1WVK
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![BU of 1wvk by Molmil](/molmil-images/mine/1wvk) | |
1XO8
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![BU of 1xo8 by Molmil](/molmil-images/mine/1xo8) | Solution structure of AT1g01470 from Arabidopsis Thaliana | 分子名称: | At1g01470 | 著者 | Singh, S, Cornilescu, C.C, Tyler, R.C, Cornilescu, G, Tonelli, M, Lee, M.S, Markley, J.L, Center for Eukaryotic Structural Genomics (CESG) | 登録日 | 2004-10-06 | 公開日 | 2004-10-19 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a late embryogenesis abundant protein (LEA14) from Arabidopsis thaliana, a cellular stress-related protein Protein Sci., 14, 2005
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4M3Q
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![BU of 4m3q by Molmil](/molmil-images/mine/4m3q) | Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1917 | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Tyrosine-protein kinase Mer, ... | 著者 | Zhang, W, Zhang, D, Stashko, M.A, DeRyckere, D, Hunter, D, Kireev, D.B, Miley, M, Cummings, C, Lee, M, Norris-Drouin, J, Stewart, W.M, Sather, S, Zhou, Y, Kirkpatrick, G, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | 登録日 | 2013-08-06 | 公開日 | 2013-11-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.718 Å) | 主引用文献 | Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors. J.Med.Chem., 56, 2013
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5DC5
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![BU of 5dc5 by Molmil](/molmil-images/mine/5dc5) | Crystal structure of D176N HDAC8 in complex with M344 | 分子名称: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, POTASSIUM ION, ... | 著者 | Decroos, C, Lee, M.S, Christianson, D.W. | 登録日 | 2015-08-23 | 公開日 | 2016-02-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry, 55, 2016
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4MH7
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![BU of 4mh7 by Molmil](/molmil-images/mine/4mh7) | Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1896 | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-butyl-2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-methylpyrimidine-5-carboxamide, ... | 著者 | Zhang, W, McIver, A, Stashko, M.A, Deryckere, D, Branchford, B.R, Hunter, D, Kireev, D.B, Miley, M.J, Norris-Drouin, J, Stewart, W.M, Lee, M, Sather, S, Zhou, Y, DiPaola, J.A, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | 登録日 | 2013-08-29 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem., 56, 2013
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1XO3
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![BU of 1xo3 by Molmil](/molmil-images/mine/1xo3) | Solution Structure of Ubiquitin like protein from Mus Musculus | 分子名称: | RIKEN cDNA 2900073H19 | 著者 | Singh, S, Tonelli, M, Tyler, R.C, Bahrami, A, Lee, M.S, Markley, J.L, Center for Eukaryotic Structural Genomics (CESG) | 登録日 | 2004-10-05 | 公開日 | 2004-10-19 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Three-dimensional structure of the AAH26994.1 protein from Mus musculus, a putative eukaryotic Urm1. Protein Sci., 14, 2005
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4MHA
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![BU of 4mha by Molmil](/molmil-images/mine/4mha) | Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1817 | 分子名称: | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Zhang, W, Mciver, A, Stashko, M.A, Deryckere, D, Branchford, B.R, Hunter, D, Kireev, D.B, Miley, D.B.M, Norris-Drouin, J, Stewart, W.M, Lee, M, Sather, S, Zhou, Y, Dipaola, J.A, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | 登録日 | 2013-08-29 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem., 56, 2013
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1T2U
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![BU of 1t2u by Molmil](/molmil-images/mine/1t2u) | Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1: structure of BRCA1 missense variant V1809F | 分子名称: | Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION | 著者 | Williams, R.S, Lee, M.S, Duong, D.D, Glover, J.N.M. | 登録日 | 2004-04-22 | 公開日 | 2004-05-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Basis of Phosphopeptide recognition by the BRCT domain of BRCA1 Nat.Struct.Mol.Biol., 11, 2004
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1Y4O
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![BU of 1y4o by Molmil](/molmil-images/mine/1y4o) | Solution structure of a mouse cytoplasmic Roadblock/LC7 dynein light chain | 分子名称: | Dynein light chain 2A, cytoplasmic | 著者 | Song, J, Tyler, R.C, Lee, M.S, Tyler, E.M, Markley, J.L, Center for Eukaryotic Structural Genomics (CESG) | 登録日 | 2004-12-01 | 公開日 | 2005-01-18 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of isoform 1 of Roadblock/LC7, a light chain in the dynein complex. J.Mol.Biol., 354, 2005
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1T2V
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![BU of 1t2v by Molmil](/molmil-images/mine/1t2v) | Structural basis of phospho-peptide recognition by the BRCT domain of BRCA1, structure with phosphopeptide | 分子名称: | BRCTide-7PS, Breast cancer type 1 susceptibility protein | 著者 | Williams, R.S, Lee, M.S, Hau, D.D, Glover, J.N.M. | 登録日 | 2004-04-22 | 公開日 | 2004-05-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1 Nat.Struct.Mol.Biol., 11, 2004
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2B0K
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![BU of 2b0k by Molmil](/molmil-images/mine/2b0k) | Crystal structure of the DB921-D(CGCGAATTCGCG)2 complex. | 分子名称: | 2-(4'-AMIDINOBIPHENYL-4-YL)-1H-BENZIMIDAZOLE-5-AMIDINE, 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION | 著者 | Miao, Y, Lee, M.P, Parkinson, G.N, Batista-Parra, A, Ismail, M.A, Neidle, S, Boykin, D.W, Wilson, W.D. | 登録日 | 2005-09-14 | 公開日 | 2005-11-22 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Out-of-Shape DNA Minor Groove Binders: Induced Fit Interactions of Heterocyclic Dications with the DNA Minor Groove. Biochemistry, 44, 2005
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1N0W
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![BU of 1n0w by Molmil](/molmil-images/mine/1n0w) | Crystal structure of a RAD51-BRCA2 BRC repeat complex | 分子名称: | 1,2-ETHANEDIOL, ARTIFICIAL GLY-SER-MSE-GLY PEPTIDE, Breast cancer type 2 susceptibility protein, ... | 著者 | Pellegrini, L, Yu, D.S, Lo, T, Anand, S, Lee, M, Blundell, T.L, Venkitaraman, A.R. | 登録日 | 2002-10-15 | 公開日 | 2002-11-27 | 最終更新日 | 2020-01-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Insights into DNA recombination from the structure of a RAD51-BRCA2 complex Nature, 420, 2002
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1ZXF
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![BU of 1zxf by Molmil](/molmil-images/mine/1zxf) | Solution structure of a self-sacrificing resistance protein, CalC from Micromonospora echinospora | 分子名称: | CalC | 著者 | Singh, S, Hager, M.H, Zhang, C, Griffith, B.R, Lee, M.S, Hallenga, K, Markley, J.L, Thorson, J.S, Center for Eukaryotic Structural Genomics (CESG) | 登録日 | 2005-06-08 | 公開日 | 2005-12-13 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural insight into the self-sacrifice mechanism of enediyne resistance. Acs Chem.Biol., 1, 2006
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4EUU
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![BU of 4euu by Molmil](/molmil-images/mine/4euu) | Structure of BX-795 Complexed with Human TBK1 Kinase Domain Phosphorylated on Ser172 | 分子名称: | GLYCEROL, IODIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, ... | 著者 | Ma, X, Helgason, E, Phung, Q.T, Quan, C.L, Iyer, R.S, Lee, M.W, Bowman, K.K, Starovasnik, M.A, Dueber, E.C. | 登録日 | 2012-04-25 | 公開日 | 2012-05-23 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation. Proc.Natl.Acad.Sci.USA, 109, 2012
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2WSY
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![BU of 2wsy by Molmil](/molmil-images/mine/2wsy) | CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, TRYPTOPHAN SYNTHASE | 著者 | Schneider, T.R, Gerhardt, E, Lee, M, Liang, P.-H, Anderson, K.S, Schlichting, I. | 登録日 | 1998-02-18 | 公開日 | 1999-03-30 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Loop closure and intersubunit communication in tryptophan synthase. Biochemistry, 37, 1998
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3MJM
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![BU of 3mjm by Molmil](/molmil-images/mine/3mjm) | His257Ala mutant of dihydroorotase from E. coli | 分子名称: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, Dihydroorotase, N-CARBAMOYL-L-ASPARTATE, ... | 著者 | Ernberg, K.E, Guss, J.M, Lee, M, Maher, M.J. | 登録日 | 2010-04-13 | 公開日 | 2011-03-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | His257Ala mutant of dihydroorotase from E. coli To be Published
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7CV0
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![BU of 7cv0 by Molmil](/molmil-images/mine/7cv0) | Crystal structure of B. halodurans NiaR in apo form | 分子名称: | Transcriptional regulator NiaR, ZINC ION | 著者 | Lee, J.Y, Lee, D.W, Park, Y.W, Lee, M.Y, Jeong, K.H. | 登録日 | 2020-08-25 | 公開日 | 2020-12-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | 主引用文献 | Structural analysis and insight into effector binding of the niacin-responsive repressor NiaR from Bacillus halodurans. Sci Rep, 10, 2020
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3LZC
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![BU of 3lzc by Molmil](/molmil-images/mine/3lzc) | Crystal structure of Dph2 from Pyrococcus horikoshii | 分子名称: | Dph2 | 著者 | Zhang, Y, Zhu, X, Torelli, A.T, Lee, M, Dzikovski, B, Koralewski, R.M, Wang, E, Freed, J, Krebs, C, Lin, H, Ealick, S.E. | 登録日 | 2010-03-01 | 公開日 | 2010-06-23 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.261 Å) | 主引用文献 | Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature, 465, 2010
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3G9Y
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![BU of 3g9y by Molmil](/molmil-images/mine/3g9y) | Crystal structure of the second zinc finger from ZRANB2/ZNF265 bound to 6 nt ssRNA sequence AGGUAA | 分子名称: | RNA (5'-R(*AP*GP*GP*UP*AP*A)-3'), ZINC ION, Zinc finger Ran-binding domain-containing protein 2 | 著者 | Loughlin, F.E, McGrath, A.P, Lee, M, Guss, J.M, Mackay, J.P. | 登録日 | 2009-02-15 | 公開日 | 2009-03-03 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences Proc.Natl.Acad.Sci.USA, 106, 2009
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4EUT
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![BU of 4eut by Molmil](/molmil-images/mine/4eut) | Structure of BX-795 Complexed with Unphosphorylated Human TBK1 Kinase-ULD Domain | 分子名称: | IODIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, SULFATE ION, ... | 著者 | Ma, X, Helgason, E, Phung, Q.T, Quan, C.L, Iyer, R.S, Lee, M.W, Bowman, K.K, Starovasnik, M.A, Dueber, E.C. | 登録日 | 2012-04-25 | 公開日 | 2012-05-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation. Proc.Natl.Acad.Sci.USA, 109, 2012
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