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PDB: 1720 results

8KGQ
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Structure of African swine fever virus topoisomerase II in complex with dsDNA
Descriptor: DNA (38-MER), DNA topoisomerase 2
Authors:Cong, J, Xin, Y, Li, X, Chen, Y.
Deposit date:2023-08-19
Release date:2024-04-03
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:Structural insights into the DNA topoisomerase II of the African swine fever virus.
Nat Commun, 15, 2024
4F20
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Crystal structures reveal the multi-ligand binding mechanism of the Staphylococcus aureus ClfB
Descriptor: Clumping factor B, MAGNESIUM ION, peptide from Dermokine
Authors:Yang, M.J, Xiang, H, Wang, J.W, Liu, B, Chen, Y.G, Liu, L, Deng, X.M, Feng, Y.
Deposit date:2012-05-07
Release date:2012-08-08
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB
Plos Pathog., 8, 2012
4F12
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Crystal structure of the extracellular domain of human GABA(B) receptor GBR2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 2
Authors:Geng, Y, Xiong, D, Mosyak, L, Malito, D.L, Kniazeff, J, Chen, Y, Burmakina, S, Quick, M, Bush, M, Javitch, J.A, Pin, J.-P, Fan, Q.R.
Deposit date:2012-05-05
Release date:2012-06-06
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2.
Nat.Neurosci., 15, 2012
3GQQ
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Crystal structure of the human retinal protein 4 (unc-119 homolog A). Northeast Structural Genomics Consortium target HR3066a
Descriptor: Protein unc-119 homolog A, UNKNOWN LIGAND
Authors:Vorobiev, S.M, Chen, Y, Seetharaman, J, Shastry, R, Foote, E.L, Ciccosanti, C, Sahdev, S, Xiao, R, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2009-03-24
Release date:2009-04-07
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.945 Å)
Cite:Crystal structure of the human retinal protein 4 (unc-119 homolog A).
To be Published
3TEF
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BU of 3tef by Molmil
Crystal Structure of the Periplasmic Catecholate-Siderophore Binding Protein VctP from Vibrio Cholerae
Descriptor: Iron(III) ABC transporter, periplasmic iron-compound-binding protein
Authors:Liu, X, Wang, Z, Liu, S, Li, N, Chen, Y, Zhu, C, Zhu, D, Wei, T, Huang, Y, Xu, S, Gu, L.
Deposit date:2011-08-13
Release date:2012-08-15
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Crystal structure of periplasmic catecholate-siderophore binding protein VctP from Vibrio cholerae at 1.7 A resolution
Febs Lett., 586, 2012
6M7I
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BU of 6m7i by Molmil
Crystal structure of KPC-2 with compound 3
Descriptor: 1-(2,4-dichlorophenyl)-4-(1H-tetrazol-5-yl)-1H-pyrazol-5-amine, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL
Authors:Akhtar, A, Chen, Y.
Deposit date:2018-08-20
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.
Acs Infect Dis., 5, 2019
3HIX
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BU of 3hix by Molmil
Crystal Structure of the Rhodanese_3 like domain from Anabaena sp Alr3790 protein. Northeast Structural Genomics Consortium Target NsR437i
Descriptor: Alr3790 protein, MANGANESE (II) ION
Authors:Vorobiev, S, Chen, Y, Forouhar, F, Maglaqui, M, Ciccosanti, C, Mao, L, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:2009-05-20
Release date:2009-05-26
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal Structure of the Rhodanese_3 like domain from Anabaena sp Alr3790 protein.
To be Published
4QSG
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Crystal structure of gas vesicle protein GvpF from Microcystis aeruginosa
Descriptor: Gas vesicle protein
Authors:Xu, B.Y, Dai, Y.N, Zhou, K, Ren, Y.M, Liu, Y.T, Chen, Y, Zhou, C.Z.
Deposit date:2014-07-03
Release date:2014-11-12
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the gas vesicle protein GvpF from the cyanobacterium Microcystis aeruginosa.
Acta Crystallogr.,Sect.D, 70, 2014
3SF5
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BU of 3sf5 by Molmil
Crystal Structure of Helicobacter pylori Urease Accessory Protein UreF/H complex
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, SULFATE ION, ...
Authors:Fong, Y.H, Chen, Y.W, Wong, K.B.
Deposit date:2011-06-12
Release date:2011-11-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Assembly of preactivation complex for urease maturation in Helicobacter pylori: crystal structure of UreF-UreH protein complex
J.Biol.Chem., 286, 2011
6MIA
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BU of 6mia by Molmil
Crystal structure of CTX-M-14 with compound 6
Descriptor: 3-(1H-tetrazol-5-ylmethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one, Beta-lactamase
Authors:Akhtar, A, Chen, Y.
Deposit date:2018-09-19
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.
Acs Infect Dis., 5, 2019
8WZ9
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BU of 8wz9 by Molmil
The crystal structure of Legionella pneumophila adenosylhomocysteinase Lpg2021 in ternary complex with NAD and adenine
Descriptor: ADENINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Gao, Y.S, Xie, R, Chen, Y.N, Ma, J.M, Ge, H.H.
Deposit date:2023-11-01
Release date:2024-11-06
Method:X-RAY DIFFRACTION (1.649 Å)
Cite:The crystal structure of Legionella pneumophila adenosylhomocysteinase Lpg2021 in ternary complex with NAD and adenine
To Be Published
6JJ3
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BRD4 in complex with 138A
Descriptor: 2-methoxy-N-[2-methyl-6-(4-methylpiperazin-1-yl)-3-oxidanylidene-2,7-diazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaen-9-yl]benzenesulfonamide, Bromodomain-containing protein 4
Authors:Xu, J, Chen, Y, Jiang, F, Zhu, J.
Deposit date:2019-02-25
Release date:2020-01-22
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.718 Å)
Cite:Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis.
J.Med.Chem., 62, 2019
6MLL
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BU of 6mll by Molmil
Crystal structure of KPC-2 with compound 7
Descriptor: 1,5-diphenyl-N-(1H-tetrazol-5-yl)-1H-pyrazole-3-carboxamide, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL
Authors:Akhtar, A, Chen, Y.
Deposit date:2018-09-27
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.
Acs Infect Dis., 5, 2019
4GM8
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BU of 4gm8 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-102
Descriptor: MM-102, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2013-07-31
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
6MNP
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BU of 6mnp by Molmil
Crystal structure of KPC-2 with compound 6
Descriptor: 3-(1H-tetrazol-5-ylmethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL
Authors:Akhtar, A, Chen, Y.
Deposit date:2018-10-02
Release date:2019-04-17
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.
Acs Infect Dis., 5, 2019
6MZ1
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BU of 6mz1 by Molmil
CTX-M-14 Class A Beta-Lactamase in Complex with Avibactam at pH 5.3
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, PHOSPHATE ION, ...
Authors:Pemberton, O.A, Chen, Y.
Deposit date:2018-11-03
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1 Å)
Cite:Mechanism of proton transfer in class A beta-lactamase catalysis and inhibition by avibactam.
Proc.Natl.Acad.Sci.USA, 117, 2020
8HYK
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BU of 8hyk by Molmil
CD-NTase EfCdnE in complex with intermediate pppU[2'-5']p
Descriptor: EfCdnE, MAGNESIUM ION, [[(2R,3R,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
Authors:Ko, T.-P, Wang, Y.-C, Yang, C.-S, Hou, M.-H, Chen, Y.
Deposit date:2023-01-06
Release date:2023-07-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.021 Å)
Cite:Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases.
Nat Commun, 14, 2023
4GM9
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BU of 4gm9 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-401
Descriptor: MM-401, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Liu, L, Dou, Y, Lei, M, Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human WD repeat domain 5 with compound MM-401
To be Published
8WZ8
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BU of 8wz8 by Molmil
The crystal structure of Legionella pneumophila adenosylhomocysteinase Lpg2021(T67A,Q69A) complex with NAD
Descriptor: Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
Authors:Gao, Y.S, Xie, R, Chen, Y.N, Ma, J.M, Ge, H.H.
Deposit date:2023-11-01
Release date:2024-11-06
Method:X-RAY DIFFRACTION (2.583 Å)
Cite:The crystal structure of Legionella pneumophila adenosylhomocysteinase Lpg2021(T67A,Q69A) complex with NAD
To Be Published
4F11
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BU of 4f11 by Molmil
Crystal structure of the extracellular domain of human GABA(B) receptor GBR2
Descriptor: Gamma-aminobutyric acid type B receptor subunit 2
Authors:Geng, Y, Xiong, D, Mosyak, L, Malito, D.L, Kniazeff, J, Chen, Y, Burmakina, S, Quick, M, Bush, M, Javitch, J.A, Pin, J.-P, Fan, Q.R.
Deposit date:2012-05-05
Release date:2012-06-06
Last modified:2012-08-15
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2.
Nat.Neurosci., 15, 2012
7JRN
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BU of 7jrn by Molmil
Crystal structure of the wild type SARS-CoV-2 papain-like protease (PLPro) with inhibitor GRL0617
Descriptor: 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, Non-structural protein 3, SULFATE ION, ...
Authors:Sacco, M, Ma, C, Wang, J, Chen, Y.
Deposit date:2020-08-12
Release date:2020-08-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay.
Acs Cent.Sci., 7, 2021
6JJB
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BU of 6jjb by Molmil
BRD4 in complex with ZZM1
Descriptor: 2-methoxy-N-(1-methyl-2-oxidanylidene-benzo[cd]indol-6-yl)benzenesulfonamide, Bromodomain-containing protein 4
Authors:Xu, J, Chen, Y, Jiang, F, Zhu, J.
Deposit date:2019-02-25
Release date:2020-01-22
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.508 Å)
Cite:Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis.
J.Med.Chem., 62, 2019
4N6E
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BU of 4n6e by Molmil
Crystal structure of Amycolatopsis orientalis BexX/CysO complex
Descriptor: Putative thiosugar synthase, SULFATE ION, ThiS/MoaD family protein
Authors:Zhang, X, Zhang, Y, Kinsland, C, Sasaki, E, Sun, H.G, Lu, M.J, Liu, T, Ou, A, Li, J, Chen, Y, Liu, H, Ealick, S.E.
Deposit date:2013-10-11
Release date:2014-05-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis.
Nature, 509, 2014
7D5O
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BU of 7d5o by Molmil
C-Src in complex with TAS-120
Descriptor: 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one, Proto-oncogene tyrosine-protein kinase Src
Authors:Qu, L.Z, Chen, Y.H.
Deposit date:2020-09-27
Release date:2021-12-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors
Commun Chem, 5, 2022
7VGH
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BU of 7vgh by Molmil
Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50B in the auto-inhibited E2P state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50B, ...
Authors:Chen, M.T, Chen, Y.
Deposit date:2021-09-16
Release date:2022-03-30
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (3.39 Å)
Cite:Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding.
Proc.Natl.Acad.Sci.USA, 119, 2022

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数据于2024-11-06公开中

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