7VGH

Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50B in the auto-inhibited E2P state

Summary for 7VGH

Entry DOI	10.2210/pdb7vgh/pdb
EMDB information	31969
Descriptor	Cell cycle control protein 50B, Phospholipid-transporting ATPase IC, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	auto-inhibited, phosphorylated, lipid flippase, lipid transport, lipid transport-translocase complex, lipid transport/translocase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	191337.50
Authors	Chen, M.T.,Chen, Y. (deposition date: 2021-09-16, release date: 2022-03-30, Last modification date: 2022-10-12)
Primary citation	Cheng, M.T.,Chen, Y.,Chen, Z.P.,Liu, X.,Zhang, Z.,Chen, Y.,Hou, W.T.,Zhou, C.Z. Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding. Proc.Natl.Acad.Sci.USA, 119:e2118656119-e2118656119, 2022 Cited by PubMed: 35349344 DOI: 10.1073/pnas.2118656119 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.39 Å)

Structure validation