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PDB: 133 件
6M2B
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BU of 6m2b by Molmil
Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416
分子名称: 2-[(E)-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-methyl-hydrazinylidene]methyl]benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Zhu, L, Li, H.
登録日2020-02-27
公開日2021-03-03
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Protein Cell, 11, 2020
6U4N
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BU of 6u4n by Molmil
Solution structure of paxillin LIM4 in complex with kindlin-2 F0
分子名称: Fermitin family homolog 2, Paxillin, ZINC ION
著者Zhu, L, Qin, J.
登録日2019-08-26
公開日2019-10-23
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion.
Structure, 27, 2019
6U4M
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BU of 6u4m by Molmil
Solution structure of paxillin LIM4
分子名称: Paxillin, ZINC ION
著者Zhu, L, Qin, J.
登録日2019-08-26
公開日2019-10-23
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion.
Structure, 27, 2019
104D
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BU of 104d by Molmil
DNA DUPLEXES FLANKED BY HYBRID DUPLEXES: THE SOLUTION STRUCTURE OF CHIMERIC JUNCTIONS IN
分子名称: DNA/RNA (5'-R(*CP*GP*CP*G)-D(P*TP*AP*TP*AP*CP*GP*CP*G)-3')
著者Zhu, L, Salazar, M, Reid, B.R.
登録日1994-12-16
公開日1995-03-31
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献DNA duplexes flanked by hybrid duplexes: the solution structure of chimeric junctions in [r(cgcg)d(TATACGCG)]2.
Biochemistry, 34, 1995
1DDP
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BU of 1ddp by Molmil
Solution structure of a CISPLATIN-INDUCED [CATAGCTATG]2 Interstrand cross-link
分子名称: Cisplatin, DNA (5'-D(*CP*AP*TP*AP*GP*CP*TP*AP*TP*G)-3')
著者Zhu, L, Huang, H, Reid, B.R, Drobny, G.P, Hopkins, P.B.
登録日1995-10-26
公開日1996-03-08
最終更新日2024-03-13
実験手法SOLUTION NMR
主引用文献Solution structure of a cisplatin-induced DNA interstrand cross-link.
Science, 270, 1995
7KXT
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BU of 7kxt by Molmil
Crystal structure of human EED
分子名称: 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Polycomb protein EED, UNKNOWN ATOM OR ION
著者Zhu, L, Dong, A, Du, D, Liu, Y, Luo, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2020-12-04
公開日2021-02-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.
J.Med.Chem., 64, 2021
5GKA
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BU of 5gka by Molmil
cryo-EM structure of human Aichi virus
分子名称: Genome polyprotein, capsid protein VP0, capsid protein VP1
著者Zhu, L, Wang, X.X, Ren, J.S, Tuthill, T.J, Fry, E.E, Rao, Z.H, Stuart, D.I.
登録日2016-07-04
公開日2016-09-21
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structure of human Aichi virus and implications for receptor binding
Nat Microbiol, 1, 2016
6M6F
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BU of 6m6f by Molmil
Solution structure of disulfide bond mutaion of the core domain of Fibroblast growth factor 21 (FGF21)
分子名称: Fibroblast growth factor 21
著者Zhu, L, Zhao, H, Wang, J.
登録日2020-03-14
公開日2021-01-20
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Dynamic folding modulation generates FGF21 variant against diabetes.
Embo Rep., 22, 2021
6M6E
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BU of 6m6e by Molmil
Solution structure of the core domain of Fibroblast growth factor 21 (FGF21)
分子名称: Fibroblast growth factor 21
著者Zhu, L, Zhao, H, Wang, J.
登録日2020-03-14
公開日2021-01-20
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Dynamic folding modulation generates FGF21 variant against diabetes.
Embo Rep., 22, 2021
6BA6
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BU of 6ba6 by Molmil
Solution structure of Rap1b/talin complex
分子名称: Ras-related protein Rap-1b, Talin-1
著者Zhu, L, Yang, J, Qin, J.
登録日2017-10-12
公開日2017-12-06
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation.
Nat Commun, 8, 2017
3SN8
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BU of 3sn8 by Molmil
Crystal structure of SARS coronavirus main protease complexed with Cm-FF-H (soaking)
分子名称: 3C-like proteinase, N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide
著者Zhu, L, Hilgenfeld, R.
登録日2011-06-29
公開日2011-09-07
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.
Antiviral Res., 92, 2011
3SNC
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BU of 3snc by Molmil
Crystal structure of SARS coronavirus main protease complexed with Ac-NSTSQ-H (soaking)
分子名称: 3C-like proteinase, DIMETHYL SULFOXIDE, Peptide aldehyde inhibitor Ac-NSTSQ-H
著者Zhu, L, Hilgenfeld, R.
登録日2011-06-29
公開日2011-09-07
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.
Antiviral Res., 92, 2011
3SNB
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BU of 3snb by Molmil
Crystal structure of SARS coronavirus main protease complexed with Ac-DSFDQ-H (soaking)
分子名称: 3C-like proteinase, Peptide aldehyde inhibitor Ac-DSFDQ-H
著者Zhu, L, Hilgenfeld, R.
登録日2011-06-29
公開日2011-09-07
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.
Antiviral Res., 92, 2011
3SNA
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BU of 3sna by Molmil
Crystal structure of SARS coronavirus main protease complexed with Ac-NSFSQ-H (soaking)
分子名称: 3C-like proteinase, Peptide aldehyde inhibitor Ac-NSFSQ-H
著者Zhu, L, Hilgenfeld, R.
登録日2011-06-29
公開日2011-09-07
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.
Antiviral Res., 92, 2011
3SZN
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BU of 3szn by Molmil
Crystal structure of SARS coronavirus main protease complexed with an alpha, beta-unsaturated ethyl ester SG75
分子名称: 3C-like proteinase, ETHYL (4R)-4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE
著者Zhu, L, Hilgenfeld, R.
登録日2011-07-19
公開日2012-07-25
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Crystal structures of SARS-Cov main protease complexed with a series of unsaturated esters
To be Published
3SND
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BU of 3snd by Molmil
Crystal structure of SARS coronavirus main protease complexed with Ac-ESTLQ-H (cocrystallization)
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 3C-like proteinase, Peptide aldehyde inhibitor Ac-ESTLQ-H
著者Zhu, L, Hilgenfeld, R.
登録日2011-06-29
公開日2011-09-07
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.
Antiviral Res., 92, 2011
3SNE
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BU of 3sne by Molmil
Crystal structure of SARS coronavirus main protease complexed with Ac-ESTLQ-H (Soaking)
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3C-like proteinase, Peptide aldehyde inhibitor Ac-ESTLQ-H
著者Zhu, L, Hilgenfeld, R.
登録日2011-06-29
公開日2011-09-07
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.
Antiviral Res., 92, 2011
3TIU
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BU of 3tiu by Molmil
Crystal structure of SARS coronavirus main protease complexed with an alpha,beta-unsaturated ethyl ester inhibitor SG82
分子名称: DIMETHYL SULFOXIDE, ETHYL (5S,8S,11R)-8-BENZYL-5-(3-TERT-BUTOXY-3-OXOPROPYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE, SARS coronavirus main protease
著者Zhu, L, Hilgenfeld, R.
登録日2011-08-22
公開日2012-08-22
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Crystal structures of SARS-Cov main protease complexed with a series of peptidic unsaturated esters
To be Published
3TIT
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BU of 3tit by Molmil
Crystal structure of SARS coronavirus main protease complexed with an alpha, beta-unsaturated ethyl ester SG81
分子名称: ETHYL (4R)-4-{[N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANYL]AMINO}-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE, SARS coronavirus main protease
著者Zhu, L, Hilgenfeld, R.
登録日2011-08-21
公開日2012-08-22
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Crystal structures of SARS-Cov main protease complexed with a series of unsaturated esters
To be Published
3TNT
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BU of 3tnt by Molmil
Crystal structure of SARS coronavirus main protease complexed with an alpha, beta-unsaturated ethyl ester inhibitor SG85
分子名称: N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide, SARS coronavirus main protease
著者Zhu, L, Hilgenfeld, R.
登録日2011-09-02
公開日2012-09-05
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Crystal structures of SARS-Cov main protease complexed with a series of peptidic unsaturated esters
To be Published
5ZID
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BU of 5zid by Molmil
Crystal Structure of human DPP-IV in complex with HL2
分子名称: (2S,3R)-2-amino-9-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-naphtho[2,1-b]pyran-8-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ...
著者Zhu, L, Li, H, Wu, F.
登録日2018-03-14
公開日2019-03-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal Structure of human DPP-IV in complex with HL2
To Be Published
6KU8
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BU of 6ku8 by Molmil
structure of HRV-C 3C protein with rupintrivir
分子名称: 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, Genome polyprotein
著者Zhu, L, Yuan, S.
登録日2019-08-31
公開日2020-03-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design.
Virol Sin, 35, 2020
7WYF
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BU of 7wyf by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with its inhibitor 50
分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
著者Zhu, L, Li, H.
登録日2022-02-16
公開日2023-02-22
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with its inhibitor 50
To Be Published
5J3J
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BU of 5j3j by Molmil
Crystal Structure of human DPP-IV in complex with HL1
分子名称: (2~{S},3~{R})-8,9-dimethoxy-3-[2,4,5-tris(fluoranyl)phenyl]-2,3-dihydro-1~{H}-benzo[f]chromen-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ...
著者Wu, F, Li, H, Zhao, Z, Zhu, L, Xu, H, Li, S.
登録日2016-03-31
公開日2017-04-05
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal Structure of human DPP-IV in complex with HL1
To Be Published
6DXK
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BU of 6dxk by Molmil
Glucocorticoid Receptor in complex with Compound 11
分子名称: (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-(3,3-dimethylbut-1-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name), Glucocorticoid receptor
著者Rew, Y, Du, X, Eksterowicz, J, Zhou, H, Jahchan, N, Zhu, L, Yan, X, Kawai, H, McGee, L.R, Medina, J.C, Huang, T, Chen, C, Zavorotinskaya, T, Sutimantanapi, D, Waszczuk, J, Jackson, E, Huang, E, Ye, Q, Fantin, V.R, Daqing, S.
登録日2018-06-29
公開日2018-10-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).
J. Med. Chem., 61, 2018

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