7C2L
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![BU of 7c2l by Molmil](/molmil-images/mine/7c2l) | S protein of SARS-CoV-2 in complex bound with 4A8 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, R.H, Zhang, Y.Y, Guo, Y.Y, Li, Y.N, Xia, L, Zhou, Q. | 登録日 | 2020-05-08 | 公開日 | 2020-07-01 | 最終更新日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2. Science, 369, 2020
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7CT5
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![BU of 7ct5 by Molmil](/molmil-images/mine/7ct5) | S protein of SARS-CoV-2 in complex bound with T-ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Guo, L, Bi, W.W, Zhang, Y.Y, Yan, R.H, Li, Y.N, Zhou, Q, Dang, B.B. | 登録日 | 2020-08-18 | 公開日 | 2020-11-18 | 最終更新日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection. Cell Res., 31, 2021
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7CWA
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![BU of 7cwa by Molmil](/molmil-images/mine/7cwa) | Crystal structure of PDE8A catalytic domain in complex with clofarabine | 分子名称: | 2-CHLORO-9-(2-DEOXY-2-FLUORO-B -D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B. | 登録日 | 2020-08-27 | 公開日 | 2021-09-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63, 2020
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7CWG
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![BU of 7cwg by Molmil](/molmil-images/mine/7cwg) | Crystal structure of PDE8A catalytic domain in complex with 3a | 分子名称: | 9-[(1~{S})-1-[4-[2,2-bis(fluoranyl)ethoxy]pyridin-2-yl]ethyl]-2-chloranyl-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B. | 登録日 | 2020-08-28 | 公開日 | 2021-09-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63, 2020
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7CWF
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![BU of 7cwf by Molmil](/molmil-images/mine/7cwf) | Crystal structure of PDE8A catalytic domain in complex with 2c | 分子名称: | 9-[[4-[2,2-bis(fluoranyl)ethoxy]pyridin-2-yl]methyl]-2-chloranyl-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B. | 登録日 | 2020-08-28 | 公開日 | 2021-09-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63, 2020
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3KH8
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![BU of 3kh8 by Molmil](/molmil-images/mine/3kh8) | Crystal structure of MaoC-like dehydratase from Phytophthora Capsici | 分子名称: | MaoC-like dehydratase | 著者 | Wang, H, Zhang, K, Guo, J, Zhou, Q, Zheng, X, Sun, F, Pang, H, Zhang, X. | 登録日 | 2009-10-30 | 公開日 | 2010-11-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of MaoC-like dehydratase from Phytophthora Capsici To be Published
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3KO1
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![BU of 3ko1 by Molmil](/molmil-images/mine/3ko1) | Cystal structure of thermosome from Acidianus tengchongensis strain S5 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperonin | 著者 | Huo, Y, Zhang, K, Hu, Z, Wang, L, Zhai, Y, Zhou, Q, Lander, G, He, Y, Zhu, J, Xu, W, Dong, Z, Sun, F. | 登録日 | 2009-11-12 | 公開日 | 2010-11-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Crystal structure of group II chaperonin in the open state. Structure, 18, 2010
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3JUE
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![BU of 3jue by Molmil](/molmil-images/mine/3jue) | Crystal Structure of ArfGAP and ANK repeat domain of ACAP1 | 分子名称: | ARFGAP with coiled-coil, ANK repeat and PH domain-containing protein 1, SULFATE ION, ... | 著者 | Pang, X, Zhang, K, Ma, J, Zhou, Q, Sun, F. | 登録日 | 2009-09-15 | 公開日 | 2010-09-22 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Mechanistic insights into regulated cargo binding by ACAP1 protein J.Biol.Chem., 287, 2012
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4M5W
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![BU of 4m5w by Molmil](/molmil-images/mine/4m5w) | Crystal structure of the USP7/HAUSP catalytic domain | 分子名称: | BROMIDE ION, Ubiquitin carboxyl-terminal hydrolase 7 | 著者 | Molland, K.L, Mesecar, A.D, Zhou, Q. | 登録日 | 2013-08-08 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.244 Å) | 主引用文献 | A 2.2 angstrom resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding. Acta Crystallogr F Struct Biol Commun, 70, 2014
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4M5X
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![BU of 4m5x by Molmil](/molmil-images/mine/4m5x) | Crystal structure of the USP7/HAUSP catalytic domain | 分子名称: | BROMIDE ION, Ubiquitin carboxyl-terminal hydrolase 7 | 著者 | Mesecar, A.D, Molland, K.L, Zhou, Q. | 登録日 | 2013-08-08 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.187 Å) | 主引用文献 | A 2.2 angstrom resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding. Acta Crystallogr F Struct Biol Commun, 70, 2014
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4NSW
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![BU of 4nsw by Molmil](/molmil-images/mine/4nsw) | Crystal structure of the BAR-PH domain of ACAP1 | 分子名称: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | 著者 | Pang, X, Zhang, K, Ma, J, Zhou, Q, Sun, F. | 登録日 | 2013-11-29 | 公開日 | 2014-10-15 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A PH Domain in ACAP1 Possesses Key Features of the BAR Domain in Promoting Membrane Curvature Dev.Cell, 31, 2014
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8EF5
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![BU of 8ef5 by Molmil](/molmil-images/mine/8ef5) | Fentanyl-bound mu-opioid receptor-Gi complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | 登録日 | 2022-09-08 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
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8EF6
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![BU of 8ef6 by Molmil](/molmil-images/mine/8ef6) | Morphine-bound mu-opioid receptor-Gi complex | 分子名称: | (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | 登録日 | 2022-09-08 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
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8EFO
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![BU of 8efo by Molmil](/molmil-images/mine/8efo) | PZM21-bound mu-opioid receptor-Gi complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | 登録日 | 2022-09-08 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
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8EFL
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![BU of 8efl by Molmil](/molmil-images/mine/8efl) | SR17018-bound mu-opioid receptor-Gi complex | 分子名称: | 5,6-dichloro-1-{1-[(4-chlorophenyl)methyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | 登録日 | 2022-09-08 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
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8EFB
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![BU of 8efb by Molmil](/molmil-images/mine/8efb) | Oliceridine-bound mu-opioid receptor-Gi complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | 登録日 | 2022-09-08 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
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8EFQ
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![BU of 8efq by Molmil](/molmil-images/mine/8efq) | DAMGO-bound mu-opioid receptor-Gi complex | 分子名称: | DAMGO, ETHANOLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | 登録日 | 2022-09-08 | 公開日 | 2022-11-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
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8Y1D
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![BU of 8y1d by Molmil](/molmil-images/mine/8y1d) | 2up-TM conformation of HKU1-B S protein after incubation of the receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Xia, L.Y, Zhang, Y.Y, Zhou, Q. | 登録日 | 2024-01-24 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2. Cell Res., 34, 2024
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8YWW
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![BU of 8yww by Molmil](/molmil-images/mine/8yww) | The structure of HKU1-B S protein with bsAb1 | 分子名称: | H4B6 heavy chain, H4B6 light chain, Spike glycoprotein, ... | 著者 | Xia, L.Y, Zhang, Y.Y, Zhou, Q. | 登録日 | 2024-04-01 | 公開日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | A novel bispecific antibody targeting two overlapping epitopes in RBD improves neutralizing potency and breadth against SARS-CoV-2. Emerg Microbes Infect, 13, 2024
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8Z1E
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![BU of 8z1e by Molmil](/molmil-images/mine/8z1e) | A homotrimeric GPCR architecture of the human cytomegalovirus (UL78) revealed by cryo-EM | 分子名称: | Uncharacterized protein UL78 | 著者 | Chen, Y, Li, Y, Zhou, Q, Cong, Z, Lin, S, Yan, J, Chen, X, Yang, D, Ying, T, Wang, M.-W. | 登録日 | 2024-04-11 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM. Cell Discov, 10, 2024
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8Y1G
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![BU of 8y1g by Molmil](/molmil-images/mine/8y1g) | The 1up conformation of the HKU1-B S protein in the apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Xia, L.Y, Zhang, Y.Y, Zhou, Q. | 登録日 | 2024-01-24 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2. Cell Res., 34, 2024
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8Y1A
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![BU of 8y1a by Molmil](/molmil-images/mine/8y1a) | 1up-1 conformation of HKU1-B S protein after incubation of the receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Xia, L.Y, Zhang, Y.Y, Zhou, Q. | 登録日 | 2024-01-24 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2. Cell Res., 34, 2024
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8Y1H
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![BU of 8y1h by Molmil](/molmil-images/mine/8y1h) | The 2up formation of the HKU1-B S protein in the apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Xia, L.Y, Zhang, Y.Y, Zhou, Q. | 登録日 | 2024-01-24 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2. Cell Res., 34, 2024
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8Y1B
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![BU of 8y1b by Molmil](/molmil-images/mine/8y1b) | 1up-2 conformation of HKU1-B S protein after incubation of the receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Xia, L.Y, Zhang, Y.Y, Zhou, Q. | 登録日 | 2024-01-24 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2. Cell Res., 34, 2024
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8Y1C
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![BU of 8y1c by Molmil](/molmil-images/mine/8y1c) | 2up-1 conformation of HKU1-B S protein after incubation of the receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Xia, L.Y, Zhang, Y.Y, Zhou, Q. | 登録日 | 2024-01-24 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2. Cell Res., 34, 2024
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