5YX2
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3RH9
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3R03
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3TG9
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![BU of 3tg9 by Molmil](/molmil-images/mine/3tg9) | The crystal structure of penicillin binding protein from Bacillus halodurans | Descriptor: | Penicillin-binding protein | Authors: | Zhang, Z, Satyanarayana, L, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2011-08-17 | Release date: | 2011-08-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure of penicillin binding protein from Bacillus halodurans To be Published
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7XAF
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![BU of 7xaf by Molmil](/molmil-images/mine/7xaf) | The crystal structure of TrkA kinase in complex with 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo- tetradecaphan-2-yne-45-carboxamide | Descriptor: | 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo-tetradecaphan-2-yne-45-carboxamide, High affinity nerve growth factor receptor | Authors: | Zhang, Z.M, Wang, Y.J. | Deposit date: | 2022-03-17 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.001182 Å) | Cite: | Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance. J.Med.Chem., 65, 2022
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3PU5
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3UBO
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![BU of 3ubo by Molmil](/molmil-images/mine/3ubo) | The crystal structure of adenosine kinase from Sinorhizobium meliloti | Descriptor: | ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, adenosine kinase | Authors: | Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2011-10-24 | Release date: | 2011-11-09 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | The crystal structure of adenosine kinase from Sinorhizobium meliloti To be Published
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3U9I
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![BU of 3u9i by Molmil](/molmil-images/mine/3u9i) | The crystal structure of Mandelate racemase/muconate lactonizing enzyme from Roseiflexus sp. | Descriptor: | Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein, SULFATE ION | Authors: | Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2011-10-19 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The crystal structure of Mandelate racemase/muconate lactonizing enzyme from Roseiflexus sp. TO BE PUBLISHED
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7VJL
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![BU of 7vjl by Molmil](/molmil-images/mine/7vjl) | The crystal structure of FGFR4 kinase domain in complex with N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-(2,2,2-trifluoroacetyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide | Descriptor: | Fibroblast growth factor receptor 4, N-[5-(aminomethyl)-4-(2-methoxyethylamino)pyridin-2-yl]-7-[2,2,2-tris(fluoranyl)ethanoyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide | Authors: | Zhang, Z.M, Wang, Y.J. | Deposit date: | 2021-09-28 | Release date: | 2022-02-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.900173 Å) | Cite: | Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design. Bioorg.Med.Chem., 50, 2021
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8HVT
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![BU of 8hvt by Molmil](/molmil-images/mine/8hvt) | Structure of the human CLC-7/Ostm1 complex reveals a novel state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, H(+)/Cl(-) exchange transporter 7, Osteopetrosis-associated transmembrane protein 1, ... | Authors: | Zhang, Z.X, Chen, L, He, J, She, J. | Deposit date: | 2022-12-27 | Release date: | 2024-01-03 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of the human CLC-7/Ostm1 complex reveals a novel state JUSTC, 53, 2023
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8I96
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![BU of 8i96 by Molmil](/molmil-images/mine/8i96) | Cryo-EM structure of TLR7/TH-407b complex | Descriptor: | (1S,3R)-5-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]carbonyladamantan-2-one, Toll-like receptor 7 | Authors: | Zhang, Z. | Deposit date: | 2023-02-06 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure of TLR7/TH-407b complex To Be Published
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7X8C
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![BU of 7x8c by Molmil](/molmil-images/mine/7x8c) | Crystal structure of a KTSC family protein from Euryarchaeon Methanolobus vulcani | Descriptor: | KTSC domain-containing protein, SODIUM ION | Authors: | Zhang, Z.F, Zhu, K.L, Chen, Y.Y, Cao, P, Gong, Y. | Deposit date: | 2022-03-12 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Biochemical and structural characterization of a KTSC family single-stranded DNA-binding protein from Euryarchaea. Int.J.Biol.Macromol., 216, 2022
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7WRY
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5W81
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![BU of 5w81 by Molmil](/molmil-images/mine/5w81) | Phosphorylated, ATP-bound structure of zebrafish cystic fibrosis transmembrane conductance regulator (CFTR) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION | Authors: | Zhang, Z, Liu, F, Chen, J. | Deposit date: | 2017-06-21 | Release date: | 2017-07-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Conformational Changes of CFTR upon Phosphorylation and ATP Binding. Cell, 170, 2017
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2Q8O
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7Y0C
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![BU of 7y0c by Molmil](/molmil-images/mine/7y0c) | Crystal structure of BD55-1403 and SARS-CoV-2 Omicron RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD55-1403 Fab heavy chain, BD55-1403 Fab light chain, ... | Authors: | Zhang, Z, Xiao, J. | Deposit date: | 2022-06-04 | Release date: | 2022-09-28 | Last modified: | 2023-04-12 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents. Cell Rep, 41, 2022
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6IVY
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![BU of 6ivy by Molmil](/molmil-images/mine/6ivy) | Crystal structure of iron-bound HitA from Pseudomonas aeruginosa | Descriptor: | FE (III) ION, PHOSPHATE ION, Periplasmic Ferric iron-binding Protein HitA | Authors: | Zhang, Z.R, Li, H.Y. | Deposit date: | 2018-12-04 | Release date: | 2019-12-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9999994 Å) | Cite: | Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa. Acs Infect Dis., 5, 2019
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7Y0W
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![BU of 7y0w by Molmil](/molmil-images/mine/7y0w) | Local structure of BD55-5514 and BD55-5840 Fab and Omicron BA.1 RBD complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD55-5514H, BD55-5514L, ... | Authors: | Zhang, Z, Xiao, J. | Deposit date: | 2022-06-06 | Release date: | 2022-09-28 | Last modified: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents. Cell Rep, 41, 2022
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7WGE
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![BU of 7wge by Molmil](/molmil-images/mine/7wge) | Human NLRP1 complexed with thioredoxin | Descriptor: | MAGNESIUM ION, NACHT, LRR and PYD domains-containing protein 1, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2021-12-28 | Release date: | 2023-07-05 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Nature, 622, 2023
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7WZ9
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![BU of 7wz9 by Molmil](/molmil-images/mine/7wz9) | HSA-In agent complex | Descriptor: | 16-chloranyl-~{N},~{N}-dimethyl-15-thia-1$l^{4},12$l^{4},13-triaza-16$l^{4}-indatetracyclo[8.6.0.0^{2,7}.0^{12,16}]hexadeca-1,3,5,7,9,11,13-heptaen-14-amine, PALMITIC ACID, Serum albumin | Authors: | Zhang, Z.L, Yang, F. | Deposit date: | 2022-02-17 | Release date: | 2023-02-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Structure of HSA-In agent complex To Be Published
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7XME
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![BU of 7xme by Molmil](/molmil-images/mine/7xme) | Structure of Influenza A virus polymerase basic protein 2 (PB2) with an azazindole derivative | Descriptor: | (2~{S},3~{S})-3-[[5-dimethoxyphosphoryl-4-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, IODIDE ION, Polymerase basic protein 2 | Authors: | Zhang, Z. | Deposit date: | 2022-04-25 | Release date: | 2023-05-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.521 Å) | Cite: | Discovery of a novel azaindole derivatives targeting the influenza PB2 cap binding region To Be Published
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7Y2D
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![BU of 7y2d by Molmil](/molmil-images/mine/7y2d) | HSA-Cu agent complex | Descriptor: | 13-methoxy-~{N},~{N}-dimethyl-2-oxa-4-thia-6,7$l^{4}-diaza-3$l^{3}-cupratricyclo[7.4.0.0^{3,7}]trideca-1(9),5,7,10,12-pentaen-5-amine, PALMITIC ACID, Serum albumin | Authors: | Zhang, Z.L, Yang, F. | Deposit date: | 2022-06-09 | Release date: | 2023-07-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of HSA-Cu agent complex To Be Published
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7UZM
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![BU of 7uzm by Molmil](/molmil-images/mine/7uzm) | Glutamate dehydrogenase 1 from human liver | Descriptor: | Glutamate dehydrogenase 1, mitochondrial | Authors: | Zhang, Z. | Deposit date: | 2022-05-09 | Release date: | 2023-05-03 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | High-resolution structural-omics of human liver enzymes. Cell Rep, 42, 2023
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7VGR
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7VGS
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