5WRO

Crystal structure of Drosophila enolase

Summary for 5WRO

• Entry DOI: 10.2210/pdb5wro/pdb
• Descriptor: Enolase, CADMIUM ION, COBALT (II) ION, ... (7 entities in total)
• Functional Keywords: enolase, hydrolyase, metabolism, lyase
• Biological source: Drosophila melanogaster (Fruit fly)
• Cellular location: Cytoplasm: P15007
• Total number of polymer chains: 1
• Total formula weight: 48033.19

Authors

Zhang, Z.,Shi, Z. (deposition date: 2016-12-02, release date: 2017-04-26, Last modification date: 2024-10-09)

Primary citation

Sun, C.,Xu, B.,Liu, X.,Zhang, Z.,Su, Z.
Crystal structure of enolase from Drosophila melanogaster.
Acta Crystallogr F Struct Biol Commun, 73:228-234, 2017

PubMed Abstract: Enolase is an important enzyme in glycolysis and various biological processes. Its dysfunction is closely associated with diseases. Here, the enolase from Drosophila melanogaster (DmENO) was purified and crystallized. A crystal of DmENO diffracted to 2.0 Å resolution and belonged to space group R32. The structure was solved by molecular replacement. Like most enolases, DmENO forms a homodimer with conserved residues in the dimer interface. DmENO possesses an open conformation in this structure and contains conserved elements for catalytic activity. This work provides a structural basis for further functional and evolutionary studies of enolase.

PubMed: 28368282
DOI: 10.1107/S2053230X17004022

Experimental method

X-RAY DIFFRACTION (2.015 Å)