Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 304 件
5FOS
DownloadVisualize
BU of 5fos by Molmil
HUMANISED MONOMERIC RADA IN COMPLEX WITH OLIGOMERISATION PEPTIDE
分子名称: DNA REPAIR AND RECOMBINATION PROTEIN RADA, GLYCEROL, PHOSPHATE ION
著者Sharpe, T, Moschetti, T, Fischer, G, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M.
登録日2015-11-26
公開日2016-10-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
5JFG
DownloadVisualize
BU of 5jfg by Molmil
Structure of humanised RadA-mutant humRadA22F in complex with peptide FHTA
分子名称: CALCIUM ION, DIMETHYL SULFOXIDE, DNA repair and recombination protein RadA, ...
著者Fischer, G, Marsh, M, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M.
登録日2016-04-19
公開日2016-10-26
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Humanisation of RadA from Pyrococcus furiosus
To Be Published
5NN1
DownloadVisualize
BU of 5nn1 by Molmil
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1)
分子名称: Serine/threonine-protein kinase PLK1
著者Kunciw, D.L, Rossmann, M, De Fusco, C, Spring, D.R, Hyvonen, M.
登録日2017-04-07
公開日2018-02-21
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.785 Å)
主引用文献Developing peptidic inhibitors of the cryptic pocket of the Polo-Like Kinase 1 Polo-Box Domain.
To Be Published
5F91
DownloadVisualize
BU of 5f91 by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator (N-(5-(azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide)
分子名称: CHLORIDE ION, FORMIC ACID, Fumarate hydratase class II, ...
著者Kasbekar, M, Fischer, G, Mott, B.T, Yasgar, A, Hyvonen, M, Boshoff, H.I, Abell, C, Barry, C.E, Thomas, C.J.
登録日2015-12-09
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
Proc.Natl.Acad.Sci.USA, 113, 2016
5F92
DownloadVisualize
BU of 5f92 by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate
分子名称: CHLORIDE ION, FORMIC ACID, Fumarate hydratase class II, ...
著者Kasbekar, M, Fischer, G, Mott, B.T, Yasgar, A, Hyvonen, M, Boshoff, H.I, Abell, C, Barry, C.E, Thomas, C.J.
登録日2015-12-09
公開日2016-06-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.859 Å)
主引用文献Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
Proc.Natl.Acad.Sci.USA, 113, 2016
7ZWG
DownloadVisualize
BU of 7zwg by Molmil
The Crystal structure of RO4493940 bound to CK2alpha
分子名称: (5~{Z})-5-(quinolin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, ...
著者Brear, P, Hyvonen, M.
登録日2022-05-19
公開日2023-05-31
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors.
Nat.Chem.Biol., 20, 2024
7ZWE
DownloadVisualize
BU of 7zwe by Molmil
The Crystal structure of GW8695 bound to CK2alpha
分子名称: 7-(1~{H}-indol-2-yl)-5-methyl-~{N}-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine, Casein kinase II subunit alpha
著者Brear, P, Hyvonen, M.
登録日2022-05-19
公開日2023-05-31
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors.
Nat.Chem.Biol., 20, 2024
5NFU
DownloadVisualize
BU of 5nfu by Molmil
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LHSpTA peptide
分子名称: Ac-LEU-HIS-SER-(TPO)-ALA, Serine/threonine-protein kinase PLK1
著者Kunciw, D.L, Rossmann, M, De Fusco, C, Spring, D.R, Hyvonen, M.
登録日2017-03-16
公開日2018-05-16
最終更新日2023-03-08
実験手法X-RAY DIFFRACTION (1.809 Å)
主引用文献A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
Sci Rep, 9, 2019
5AJ9
DownloadVisualize
BU of 5aj9 by Molmil
G7 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ARYLSULFATASE, CALCIUM ION, ...
著者Miton, C.M, Fischer, G, Jonas, S, Mohammed, M.F, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F.
登録日2015-02-20
公開日2016-03-16
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5FPK
DownloadVisualize
BU of 5fpk by Molmil
MONOMERIC RADA IN COMPLEX WITH FATA TETRAPEPTIDE
分子名称: DNA REPAIR AND RECOMBINATION PROTEIN RADA, FHTG PEPTIDE, PHOSPHATE ION
著者Scott, D.E, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M.
登録日2015-12-01
公開日2016-03-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.343 Å)
主引用文献Structure Activity Relationship of the Peptide Binding Motif Mediating the Rad51:Brca2 Protein-Protein Interaction.
FEBS Lett., 590, 2016
6YPN
DownloadVisualize
BU of 6ypn by Molmil
Crystal Structure of CK2alpha with 2 molecules of ADP bound
分子名称: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, Casein kinase II subunit alpha, ...
著者Brear, P, Hyvonen, M.
登録日2020-04-16
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Proposed Allosteric Inhibitors Bind to the ATP Site of CK2 alpha.
J.Med.Chem., 63, 2020
5FOT
DownloadVisualize
BU of 5fot by Molmil
HUMANISED MONOMERIC RADA IN COMPLEX WITH FHTU TETRAPEPTIDE
分子名称: DNA REPAIR AND RECOMBINATION PROTEIN RADA, FHTU PEPTIDE, PHOSPHATE ION
著者Scott, D.E, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M.
登録日2015-11-26
公開日2016-03-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.189 Å)
主引用文献Structure Activity Relationship of the Peptide Binding Motif Mediating the Rad51:Brca2 Protein-Protein Interaction.
FEBS Lett., 590, 2016
5FOU
DownloadVisualize
BU of 5fou by Molmil
HUMANISED MONOMERIC RADA IN COMPLEX WITH FHPA TETRAPEPTIDE
分子名称: DNA REPAIR AND RECOMBINATION PROTEIN RADA, FHPA PEPTIDE, PHOSPHATE ION
著者Scott, D.E, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M.
登録日2015-11-26
公開日2016-03-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure Activity Relationship of the Peptide Binding Motif Mediating the Rad51:Brca2 Protein-Protein Interaction.
FEBS Lett., 590, 2016
5FOX
DownloadVisualize
BU of 5fox by Molmil
HUMANISED MONOMERIC RADA IN COMPLEX WITH FHAA TETRAPEPTIDE
分子名称: DNA REPAIR AND RECOMBINATION PROTEIN RADA, FHAA PEPTIDE, GLYCEROL, ...
著者Scott, D.E, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M.
登録日2015-11-26
公開日2016-03-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structure Activity Relationship of the Peptide Binding Motif Mediating the Rad51:Brca2 Protein-Protein Interaction.
FEBS Lett., 590, 2016
5FOW
DownloadVisualize
BU of 5fow by Molmil
HUMANISED MONOMERIC RADA IN COMPLEX WITH WHTA TETRAPEPTIDE
分子名称: DNA repair and recombination protein RadA, PHOSPHATE ION, WHTA PEPTIDE
著者Scott, D.E, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M.
登録日2015-11-26
公開日2016-03-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.797 Å)
主引用文献Structure Activity Relationship of the Peptide Binding Motif Mediating the Rad51:Brca2 Protein-Protein Interaction.
FEBS Lett., 590, 2016
5FOV
DownloadVisualize
BU of 5fov by Molmil
HUMANISED MONOMERIC RADA IN COMPLEX WITH FHTG TETRAPEPTIDE
分子名称: DNA repair and recombination protein RadA, FHTG PEPTIDE, GLYCEROL, ...
著者Scott, D.E, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M.
登録日2015-11-26
公開日2016-03-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.739 Å)
主引用文献Structure Activity Relationship of the Peptide Binding Motif Mediating the Rad51:Brca2 Protein-Protein Interaction.
FEBS Lett., 590, 2016
8BR9
DownloadVisualize
BU of 8br9 by Molmil
Stapled peptide SP24 in complex with humanised RadA mutant HumRadA22
分子名称: 4,6-diethylpyrimidin-2-amine, ADENOSINE-5'-DIPHOSPHATE, Breast cancer type 2 susceptibility protein, ...
著者Pantelejevs, T, Hyvonen, M.
登録日2022-11-22
公開日2023-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
Chem Sci, 14, 2023
6YJE
DownloadVisualize
BU of 6yje by Molmil
Plasmoodium vivax phosphoglycerate kinase bound to nitrofuran inhibitor from PEG3350 and ammonium acetate at pH 5.5
分子名称: (2~{S})-2-(5-nitrofuran-2-yl)-2,3,5,6,7,8-hexahydro-1~{H}-[1]benzothiolo[2,3-d]pyrimidin-4-one, Phosphoglycerate kinase
著者Blaszczyk, B.K, Hyvonen, M.
登録日2020-04-03
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Phosphoglycerate Kinase as a potential target for antimalarial therapy
to be published
5NJE
DownloadVisualize
BU of 5nje by Molmil
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with Alpha-Bromo-3-Iodotoluene.
分子名称: Alpha-Bromo-3-Iodotoluene, Serine/threonine-protein kinase PLK1
著者Kunciw, D.L, Rossmann, M, Stokes, J.E, De Fusco, C, Spring, D.R, Hyvonen, M.
登録日2017-03-28
公開日2018-05-16
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.978 Å)
主引用文献A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
Sci Rep, 9, 2019
5NMM
DownloadVisualize
BU of 5nmm by Molmil
The structure of the polo-box domain (PBD) of Plk1 in complex with Alpha-Bromo-3-Iodotoluene.
分子名称: Alpha-Bromo-3-Iodotoluene, Serine/threonine-protein kinase PLK1
著者Kunciw, D.L, Rossmann, M, Stokes, J.E, De Fusco, C, Spring, D.R, Hyvonen, M.
登録日2017-04-06
公開日2018-02-21
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
Sci Rep, 9, 2019
5NB8
DownloadVisualize
BU of 5nb8 by Molmil
Structure of vWC domain from CCN3
分子名称: GLYCEROL, IMIDAZOLE, Protein NOV homolog
著者Xu, E.-R, Hyvonen, M.
登録日2017-03-01
公開日2017-06-14
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2.
J. Biol. Chem., 292, 2017
6GMD
DownloadVisualize
BU of 6gmd by Molmil
The crystal structure of CK2alpha in complex with compound 3
分子名称: ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, Casein kinase II subunit alpha, ...
著者Brear, P, Iegre, J, North, A, De Fusco, C, Georgiou, K, Lubin, A, Carro, L, Sore, H, Hyvonen, M, Spring, D.
登録日2018-05-25
公開日2018-06-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Novel non-ATP competitive small molecules targeting the CK2 alpha / beta interface.
Bioorg. Med. Chem., 26, 2018
1LR7
DownloadVisualize
BU of 1lr7 by Molmil
Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue sucrose octasulphate (SOS)
分子名称: SULFATE ION, follistatin
著者Innis, C.A, Hyvonen, M.
登録日2002-05-15
公開日2003-07-29
最終更新日2022-12-21
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278, 2003
1LR9
DownloadVisualize
BU of 1lr9 by Molmil
STRUCTURE OF Fs1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN
分子名称: Follistatin
著者Innis, C.A, Hyvonen, M.
登録日2002-05-15
公開日2003-07-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278, 2003
1LR8
DownloadVisualize
BU of 1lr8 by Molmil
Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue D-myo-inositol hexasulphate (Ins6S)
分子名称: D-MYO-INOSITOL-HEXASULPHATE, Follistatin
著者Innis, C.A, Hyvonen, M.
登録日2002-05-15
公開日2003-07-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278, 2003

222415

件を2024-07-10に公開中

PDB statisticsPDBj update infoContact PDBjnumon