5F92

Fumarate hydratase of Mycobacterium tuberculosis in complex with formate

Summary for 5F92

Entry DOI	10.2210/pdb5f92/pdb
Related	5F91
Descriptor	Fumarate hydratase class II, FORMIC ACID, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	hydratase, metabolism, tuberculosis, lyase
Biological source	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Cellular location	Cytoplasm : P9WN92
Total number of polymer chains	4
Total formula weight	210926.61
Authors	Kasbekar, M.,Fischer, G.,Mott, B.T.,Yasgar, A.,Hyvonen, M.,Boshoff, H.I.,Abell, C.,Barry, C.E.,Thomas, C.J. (deposition date: 2015-12-09, release date: 2016-06-22, Last modification date: 2024-03-06)
Primary citation	Kasbekar, M.,Fischer, G.,Mott, B.T.,Yasgar, A.,Hyvonen, M.,Boshoff, H.I.,Abell, C.,Barry, C.E.,Thomas, C.J. Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site. Proc.Natl.Acad.Sci.USA, 113:7503-7508, 2016 Cited by PubMed: 27325754 DOI: 10.1073/pnas.1600630113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.859 Å)

Structure validation