Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue D-myo-inositol hexasulphate (Ins6S)

Summary for 1LR8

Related1LR7 1LR9
DescriptorFollistatin, D-MYO-INOSITOL-HEXASULPHATE (3 entities in total)
Functional Keywordscystine-rich, d-myo-inositol hexasulphate, hormone-growth factor complex, hormone/growth factor
Biological sourceRattus norvegicus (Norway rat)
Total number of polymer chains1
Total molecular weight9003.35
Innis, C.A.,Hyvonen, M. (deposition date: 2002-05-15, release date: 2003-07-29, Last modification date: 2019-07-24)
Primary citation
Innis, C.A.,Hyvonen, M.
Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278:39969-39977, 2003
PubMed: 12867435 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M211284200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25880 1.8% 5.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-11-18