4MKW
 
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8E4L
 | | The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2 | | Descriptor: | 3-isothiocyanatoprop-1-ene, CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, ... | | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | Deposit date: | 2022-08-18 | | Release date: | 2022-10-26 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
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8E4O
 | | The closed C1-state mouse TRPM8 structure in complex with putative PI(4,5)P2 | | Descriptor: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | Deposit date: | 2022-08-18 | | Release date: | 2022-10-26 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
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8E4N
 | | The closed C1-state mouse TRPM8 structure in complex with PI(4,5)P2 | | Descriptor: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | Deposit date: | 2022-08-18 | | Release date: | 2022-10-26 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
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8E4Q
 | | The closed C0-state flycatcher TRPM8 structure in complex with PI(4,5)P2 | | Descriptor: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | Deposit date: | 2022-08-18 | | Release date: | 2022-10-26 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
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8E4P
 | | Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | Deposit date: | 2022-08-18 | | Release date: | 2022-10-26 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
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8E4M
 | | The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2 | | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | Deposit date: | 2022-08-18 | | Release date: | 2022-10-26 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
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6W6G
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6W6H
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6W6I
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6W6E
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6W6J
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4WV1
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7LJF
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7X1G
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7X1H
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7X1I
 | | Cryo-EM structure of human BTR1 in the outward-facing state. | | Descriptor: | Isoform 1 of Solute carrier family 4 member 11, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | | Authors: | Yin, Y, Lu, Y, Zuo, P. | | Deposit date: | 2022-02-24 | | Release date: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP 2.
Nat Commun, 14, 2023
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7X1J
 | | Cryo-EM structure of human BTR1 in the outward-facing state in the presence of NH4Cl. | | Descriptor: | Isoform 1 of Solute carrier family 4 member 11, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | | Authors: | Yin, Y, Lu, Y, Zuo, P. | | Deposit date: | 2022-02-24 | | Release date: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP 2.
Nat Commun, 14, 2023
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7L6N
 | | The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with three locally refined ClpB middle domains and three DnaK nucleotide binding domains | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, Chaperone protein DnaK, ... | | Authors: | Yin, Y.Y, Feng, X, Li, H. | | Deposit date: | 2020-12-23 | | Release date: | 2021-05-26 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
Cell Rep, 35, 2021
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9B6G
 | | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMTB | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide, ... | | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | | Deposit date: | 2024-03-25 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.81 Å) | | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
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9B6I
 | | Cryo-EM structure of the avian great tit TRPM8 channel in complex with the antagonist TC-I 2014 | | Descriptor: | 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | | Deposit date: | 2024-03-25 | | Release date: | 2024-08-21 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
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9B6F
 | | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMG2850 | | Descriptor: | (8R)-8-[4-(trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-5,8-dihydro-1,7-naphthyridine-7(6H)-carboxamide, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | | Deposit date: | 2024-03-25 | | Release date: | 2024-08-21 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
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9B6E
 | | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 | | Descriptor: | 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | | Deposit date: | 2024-03-25 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
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9B6D
 | | Cryo-EM structure of the mouse TRPM8 channel in the ligand-free desensitized state | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | | Deposit date: | 2024-03-25 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
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9B6H
 | | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 and the cooling agonist C3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | | Deposit date: | 2024-03-25 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
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