6VNW
 
 | | Cryo-EM structure of apo-BBSome | | 分子名称: | BBS1 domain-containing protein, Bardet-Biedl syndrome 18 protein, Bardet-Biedl syndrome 2 protein homolog, ... | | 著者 | Yang, S, Walz, T, Nachury, M, Chou, H. | | 登録日 | 2020-01-29 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes.
Elife, 9, 2020
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6VOA
 | | Cryo-EM structure of the BBSome-ARL6 complex | | 分子名称: | ADP-ribosylation factor-like protein 6, BBS1 domain-containing protein, Bardet-Biedl syndrome 18 protein, ... | | 著者 | Yang, S, Walz, T, Nachury, M.V. | | 登録日 | 2020-01-30 | | 公開日 | 2020-06-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes.
Elife, 9, 2020
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4JL3
 | | Crystal structure of ms6564-dna complex | | 分子名称: | DNA (31-MER), Transcriptional regulator, TetR family | | 著者 | Yang, S.F, Gao, Z.Q, He, Z.G, Dong, Y.H. | | 登録日 | 2013-03-12 | | 公開日 | 2013-06-26 | | 最終更新日 | 2022-08-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for interaction between Mycobacterium smegmatis Ms6564, a TetR family master regulator, and its target DNA.
J.Biol.Chem., 288, 2013
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4JKZ
 | | Crystal structure of ms6564 from mycobacterium smegmatis | | 分子名称: | Transcriptional regulator, TetR family | | 著者 | Yang, S.F, Gao, Z.Q, He, Z.G, Dong, Y.H. | | 登録日 | 2013-03-12 | | 公開日 | 2013-06-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for interaction between Mycobacterium smegmatis Ms6564, a TetR family master regulator, and its target DNA.
J.Biol.Chem., 288, 2013
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3L43
 | | Crystal structure of the dynamin 3 GTPase domain bound with GDP | | 分子名称: | Dynamin-3, GUANOSINE-5'-DIPHOSPHATE, UNKNOWN ATOM OR ION | | 著者 | Yang, S, Tempel, W, Tong, Y, Nedyalkova, L, Guan, X, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2009-12-18 | | 公開日 | 2010-01-19 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Crystal structure of the dynamin 3 GTPase domain bound with GDP
to be published
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3UI7
 | | Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia | | 分子名称: | 6-methoxy-3,8-dimethyl-4-(morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]quinoline, MAGNESIUM ION, ZINC ION, ... | | 著者 | Yang, S, Smotryski, J, Mcelroy, W, Ho, G, Tulshian, D, Greenlee, W.J, Hodgson, R, Xiao, L, Hruza, A. | | 登録日 | 2011-11-04 | | 公開日 | 2011-12-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Bioorg.Med.Chem.Lett., 22, 2012
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5JJY
 | | Crystal structure of SETD2 bound to histone H3.3 K36M peptide | | 分子名称: | Histone H3.3, Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Yang, S, Zheng, X, Li, H. | | 登録日 | 2016-04-25 | | 公開日 | 2016-11-02 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | | 主引用文献 | Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase
Genes Dev., 30, 2016
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4GOV
 | | The crystal structure of human fascin 1 S39D mutant | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BROMIDE ION, CHLORIDE ION, ... | | 著者 | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | | 登録日 | 2012-08-20 | | 公開日 | 2012-11-28 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Molecular mechanism of fascin function in filopodial formation.
J.Biol.Chem., 288, 2013
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4GP3
 | | The crystal structure of human fascin 1 K358A mutant | | 分子名称: | BROMIDE ION, CHLORIDE ION, Fascin, ... | | 著者 | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | | 登録日 | 2012-08-20 | | 公開日 | 2012-11-28 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Molecular mechanism of fascin function in filopodial formation.
J.Biol.Chem., 288, 2013
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4GOY
 | | The crystal structure of human fascin 1 K41A mutant | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BROMIDE ION, CHLORIDE ION, ... | | 著者 | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | | 登録日 | 2012-08-20 | | 公開日 | 2012-11-28 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular mechanism of fascin function in filopodial formation.
J.Biol.Chem., 288, 2013
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4GP0
 | | The crystal structure of human fascin 1 R149A K150A R151A mutant | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BROMIDE ION, ... | | 著者 | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | | 登録日 | 2012-08-20 | | 公開日 | 2012-11-28 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Molecular mechanism of fascin function in filopodial formation.
J.Biol.Chem., 288, 2013
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7SC5
 | | Cytoplasmic tail deleted HIV Env trimer in nanodisc | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | | 著者 | Yang, S, Walz, T. | | 登録日 | 2021-09-27 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-02-22 | | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | | 主引用文献 | Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack.
Nat Commun, 13, 2022
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7SD3
 | | Cytoplasmic tail deleted HIV-1 Env bound with three 4E10 Fabs | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4E10 Fab heavy chain, ... | | 著者 | Yang, S, Walz, T. | | 登録日 | 2021-09-29 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-02-22 | | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | | 主引用文献 | Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack.
Nat Commun, 13, 2022
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5XBZ
 | | Crystal structure of GH family 81 beta-1,3-glucanase from Rhizomucr miehei complexed with laminaripentaose | | 分子名称: | Endo-beta-1,3-glucanase, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose, ... | | 著者 | Yang, S, Qin, Z, Zhou, P, Yan, Q, Jiang, Z. | | 登録日 | 2017-03-21 | | 公開日 | 2018-03-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Catalytic mechanism of glycoside hydrolase family 81 beta-1,3-glucanase
To Be Published
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7EF6
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7EF7
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6J9J
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2KAP
 | | Solution structure of DLC1-SAM | | 分子名称: | Rho GTPase-activating protein 7 | | 著者 | Yang, S, Yang, D. | | 登録日 | 2008-11-12 | | 公開日 | 2009-10-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level
Biochemistry, 48, 2009
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2GYT
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2KET
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6BD4
 | | Crystal structure of human apo-Frizzled4 receptor | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Frizzled-4/Rubredoxin chimeric protein, OLEIC ACID, ... | | 著者 | Yang, S, Wu, Y, Pu, M, Chen, Y, Dong, S, Guo, Y, Han, G.Y, Stevens, R.C, Zhao, S, Xu, F. | | 登録日 | 2017-10-21 | | 公開日 | 2018-08-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
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6L00
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8IPJ
 | | Crystal structure of the Legionella effector protein MavL with ADPR-Ub | | 分子名称: | MavL, Ubiquitin, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | 著者 | Ouyang, S, Guan, H. | | 登録日 | 2023-03-14 | | 公開日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | | 主引用文献 | Crystal structure of the Legionella effector protein MavL with ADPR-Ub
To Be Published
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8IPW
 | | The sturecture of Legionella effector protein MavL with ADPR | | 分子名称: | MavL, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | 著者 | Ouyang, S, Hongxin, G. | | 登録日 | 2023-03-15 | | 公開日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | The sturecture of Legionella effector protein MavL with ADPR
To Be Published
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6M6U
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