7RKL
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![BU of 7rkl by Molmil](/molmil-images/mine/7rkl) | Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with II399 (P1 space group) | 分子名称: | 3-[3-(acetyl{[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl}amino)prop-1-yn-1-yl]benzamide, NNMT protein, SULFATE ION | 著者 | Yadav, R, Noinaj, N, Iyamu, I.D, Huang, R. | 登録日 | 2021-07-22 | 公開日 | 2022-07-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Exploring Unconventional SAM Analogues To Build Cell-Potent Bisubstrate Inhibitors for Nicotinamide N-Methyltransferase. Angew.Chem.Int.Ed.Engl., 61, 2022
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7RKK
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![BU of 7rkk by Molmil](/molmil-images/mine/7rkk) | Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with II399 (C2 space group) | 分子名称: | 3-[3-(acetyl{[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl}amino)prop-1-yn-1-yl]benzamide, NNMT protein | 著者 | Yadav, R, Noinaj, N, Iyamu, I.D, Huang, R. | 登録日 | 2021-07-22 | 公開日 | 2022-07-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Exploring Unconventional SAM Analogues To Build Cell-Potent Bisubstrate Inhibitors for Nicotinamide N-Methyltransferase. Angew.Chem.Int.Ed.Engl., 61, 2022
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2LGJ
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![BU of 2lgj by Molmil](/molmil-images/mine/2lgj) | Solution structure of MsPTH | 分子名称: | Peptidyl-tRNA hydrolase | 著者 | Yadav, R, Pathak, P, Pulavarti, S, Jain, A, Kumar, A, Shukla, V, Arora, A. | 登録日 | 2011-07-27 | 公開日 | 2012-08-01 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and backbone dynamics of Peptidyl t-RNA hydrolase from Mycobacterium smegmatis To be Published
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7F7Y
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![BU of 7f7y by Molmil](/molmil-images/mine/7f7y) | |
7KWI
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![BU of 7kwi by Molmil](/molmil-images/mine/7kwi) | |
7JRD
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7SOK
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![BU of 7sok by Molmil](/molmil-images/mine/7sok) | Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor II329 | 分子名称: | (2S)-2-amino-4-([3-(3-carbamoylphenyl)prop-2-yn-1-yl]{[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl}amino)butanoic acid, DI(HYDROXYETHYL)ETHER, NNMT protein | 著者 | Yadav, R, Iyamu, I.D, Huang, R, Noinaj, N. | 登録日 | 2021-10-31 | 公開日 | 2022-11-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor II329 To Be Published
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7SS1
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![BU of 7ss1 by Molmil](/molmil-images/mine/7ss1) | The structure of NTMT1 in complex with compound GD433 | 分子名称: | (1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl {2-[2-(4-fluoro-3-hydroxyphenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate, N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Yadav, R, Guangping, D, Deng, Y, Huang, R, Noinaj, N. | 登録日 | 2021-11-09 | 公開日 | 2022-11-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of a first-in-class small molecule inhibitor for Protein N-terminal methyltransferases 1/2 To Be Published
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7U1M
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![BU of 7u1m by Molmil](/molmil-images/mine/7u1m) | Crystal structure of NTMT1 in complex with compound YD206 | 分子名称: | (1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl {2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate, N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Yadav, R, Noinaj, N. | 登録日 | 2022-02-21 | 公開日 | 2022-12-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | 主引用文献 | Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner. J.Med.Chem., 65, 2022
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5U9A
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![BU of 5u9a by Molmil](/molmil-images/mine/5u9a) | |
5V35
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![BU of 5v35 by Molmil](/molmil-images/mine/5v35) | Crystal structure of V71F mutant of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with S-farnesyl-L-cysteine methyl ester | 分子名称: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), FARNESYL | 著者 | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | 登録日 | 2017-03-06 | 公開日 | 2017-07-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U9K
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6PX0
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![BU of 6px0 by Molmil](/molmil-images/mine/6px0) | |
7W7I
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![BU of 7w7i by Molmil](/molmil-images/mine/7w7i) | |
7VCR
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![BU of 7vcr by Molmil](/molmil-images/mine/7vcr) | |
7VCN
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![BU of 7vcn by Molmil](/molmil-images/mine/7vcn) | |
7W6B
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![BU of 7w6b by Molmil](/molmil-images/mine/7w6b) | |
7N88
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5U9J
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![BU of 5u9j by Molmil](/molmil-images/mine/5u9j) | Crystal structure of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with geranyl geranyl pyrophoshate | 分子名称: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), GERAN-8-YL GERAN, ISOPROPYL ALCOHOL, ... | 著者 | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | 登録日 | 2016-12-16 | 公開日 | 2017-07-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U9I
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![BU of 5u9i by Molmil](/molmil-images/mine/5u9i) | Crystal structure of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with S-farnesyl-L-cysteine methyl ester | 分子名称: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), FARNESYL | 著者 | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | 登録日 | 2016-12-16 | 公開日 | 2017-07-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2NAF
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![BU of 2naf by Molmil](/molmil-images/mine/2naf) | Solution structure of peptidyl-tRNA hydrolase from Mycobacterium smegmatis | 分子名称: | Peptidyl-tRNA hydrolase | 著者 | Yadav, R, Pathak, P, Fatma, F, Kabra, A, Pulavarti, S, Jain, A, Kumar, A, Shukla, V, Arora, A. | 登録日 | 2015-12-23 | 公開日 | 2017-01-11 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural characterization of peptidyl-tRNA hydrolase from Mycobacterium smegmatis by NMR spectroscopy. Biochim.Biophys.Acta, 1864, 2016
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2L72
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![BU of 2l72 by Molmil](/molmil-images/mine/2l72) | Solution structure and dynamics of ADF from Toxoplasma gondii (TgADF) | 分子名称: | Actin depolymerizing factor, putative | 著者 | Pathak, P.P, Shukla, V.K, Yadav, R, Jain, A, Srivastava, S, Tripathi, S, Pulavarti, S.V.S.R.K, Arora, A. | 登録日 | 2010-12-01 | 公開日 | 2011-08-17 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and dynamics of ADF from Toxoplasma gondii J.Struct.Biol., 176, 2011
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4BVM
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![BU of 4bvm by Molmil](/molmil-images/mine/4bvm) | The peripheral membrane protein P2 from human myelin at atomic resolution | 分子名称: | CITRIC ACID, MYELIN P2 PROTEIN, PALMITIC ACID, ... | 著者 | Ruskamo, S, Yadav, R.P, Kursula, P. | 登録日 | 2013-06-26 | 公開日 | 2014-01-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (0.93 Å) | 主引用文献 | Atomic Resolution View Into the Structure-Function Relationships of the Human Myelin Peripheral Membrane Protein P2 Acta Crystallogr.,Sect.D, 70, 2014
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3P2J
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![BU of 3p2j by Molmil](/molmil-images/mine/3p2j) | Crystal structure of peptidyl-tRNA hydrolase from Mycobacterium smegmatis at 2.2 A resolution | 分子名称: | Peptidyl-tRNA hydrolase | 著者 | Kumar, A, Singh, A, Yadav, R, Sinha, M, Arora, A, Sharma, S, Singh, T.P. | 登録日 | 2010-10-02 | 公開日 | 2010-11-17 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Crystal Structure of peptidyl-tRNA hydrolase from Mycobacterium smegmatis at 2.2 A resolution To be Published
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3KJZ
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![BU of 3kjz by Molmil](/molmil-images/mine/3kjz) | Crystal structure of native peptidyl-tRNA hydrolase from Mycobacterium smegmatis | 分子名称: | Peptidyl-tRNA hydrolase | 著者 | Kumar, A, Singh, N, Yadav, R, Prem Kumar, R, Sharma, S, Arora, A, Singh, T.P. | 登録日 | 2009-11-04 | 公開日 | 2010-08-18 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of peptidyl-tRNA hydrolase from mycobacterium smegmatis reveals novel features related to enzyme dynamics. Int J Biochem Mol Biol, 3, 2012
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