7SOK

Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor II329

Summary for 7SOK

• Entry DOI: 10.2210/pdb7sok/pdb
• Descriptor: NNMT protein, (2S)-2-amino-4-([3-(3-carbamoylphenyl)prop-2-yn-1-yl]{[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl}amino)butanoic acid, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• Functional Keywords: nnmt1, inhibitor, methylation, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 128877.09

Authors

Yadav, R.,Iyamu, I.D.,Huang, R.,Noinaj, N. (deposition date: 2021-10-31, release date: 2022-11-02, Last modification date: 2023-10-18)

• Primary citation: Iyamu, I.,Vilseck, J.Z.,Yadav, R.,Noinaj, N.,Huang, R.; Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor II329; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.08 Å)