7SS1

The structure of NTMT1 in complex with compound GD433

Summary for 7SS1

• Entry DOI: 10.2210/pdb7ss1/pdb
• Descriptor: N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, (1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl {2-[2-(4-fluoro-3-hydroxyphenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate (3 entities in total)
• Functional Keywords: ntmt1, methyltransferase, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 56219.94

Authors

Yadav, R.,Guangping, D.,Deng, Y.,Huang, R.,Noinaj, N. (deposition date: 2021-11-09, release date: 2022-11-16, Last modification date: 2023-10-18)

• Primary citation: Yadav, R.,Guangping, D.,Deng, Y.,Huang, R.,Noinaj, N.; Discovery of a first-in-class small molecule inhibitor for Protein N-terminal methyltransferases 1/2; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)