7U1M
Crystal structure of NTMT1 in complex with compound YD206
Summary for 7U1M
| Entry DOI | 10.2210/pdb7u1m/pdb |
| Descriptor | N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, (1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl {2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate (3 entities in total) |
| Functional Keywords | methyltransferase, enzyme, inhibitor complex, transferase, transferase-inhibitor complex, transferase/inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 56187.94 |
| Authors | Yadav, R.,Noinaj, N. (deposition date: 2022-02-21, release date: 2022-12-14, Last modification date: 2023-10-25) |
| Primary citation | Dong, G.,Deng, Y.,Yasgar, A.,Yadav, R.,Talley, D.,Zakharov, A.V.,Jain, S.,Rai, G.,Noinaj, N.,Simeonov, A.,Huang, R. Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner. J.Med.Chem., 65:12334-12345, 2022 Cited by PubMed: 36074125DOI: 10.1021/acs.jmedchem.2c01050 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.17 Å) |
Structure validation
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